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1. (WO2018102256) PYRROLIDINONE COMPOUNDS
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Pub. No.: WO/2018/102256 International Application No.: PCT/US2017/063285
Publication Date: 07.06.2018 International Filing Date: 27.11.2017
IPC:
C07D 405/14 (2006.01) ,A61P 3/04 (2006.01) ,A61P 3/10 (2006.01) ,A61K 31/4025 (2006.01)
C CHEMISTRY; METALLURGY
07
ORGANIC CHEMISTRY
D
HETEROCYCLIC COMPOUNDS
405
Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom
14
containing three or more hetero rings
A HUMAN NECESSITIES
61
MEDICAL OR VETERINARY SCIENCE; HYGIENE
P
SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
3
Drugs for disorders of the metabolism
04
Anorexiants; Antiobesity agents
A HUMAN NECESSITIES
61
MEDICAL OR VETERINARY SCIENCE; HYGIENE
P
SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
3
Drugs for disorders of the metabolism
08
for glucose homeostasis
10
for hyperglycaemia, e.g. antidiabetics
A HUMAN NECESSITIES
61
MEDICAL OR VETERINARY SCIENCE; HYGIENE
K
PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
31
Medicinal preparations containing organic active ingredients
33
Heterocyclic compounds
395
having nitrogen as a ring hetero atom, e.g. guanethidine, rifamycins
40
having five-membered rings with one nitrogen as the only ring hetero atom, e.g. sulpiride, succinimide, tolmetin, buflomedil
4025
not condensed and containing further heterocyclic rings, e.g. cromakalim
Applicants:
ELI LILLY AND COMPANY [US/US]; Lilly Corporate Center Indianapolis, Indiana 46285, US
LILLY CHINA RESEARCH AND DEVELOPMENT CO., LTD [CN/CN]; 780 Cailun Road, Rm. 819, Zhangjiang High Technology Park, Pudong New Area Shanghai 20000, CN (MG)
Inventors:
HO, Koc Kan; US
QUAN, Weiguo; US
ZHOU, Jingye; US
Agent:
TUCKER, R. Craig; US
EBERSOLE, Ted J.; US
Priority Data:
PCT/CN2016/10824001.12.2016CN
Title (EN) PYRROLIDINONE COMPOUNDS
(FR) COMPOSÉS PYRROLIDINONE
Abstract:
(EN) The present invention provides compounds which are of the formula and wherein X is selected from the group consisting of,,, and; R is selected from the group consisting of,,,,, and; Q is selected from the group consisting of,,, and; and R2 is selected from the group consisting of,,,,,, and; or a pharmaceutically acceptable salt thereof, methods for treating obesity, type II diabetes, and compositions.
(FR) La présente invention concerne des composés de la formule dans laquelle X est choisi dans le groupe constitué de ,,, et ; R est choisi dans le groupe constitué de ,,,,, et ; Q est choisi dans le groupe constitué de ,,, et ; et R2 est choisi dans le groupe constitué de ,,,,,, et ; ou un sel pharmaceutiquement acceptable de ceux-ci, des procédés pour traiter l'obésité, le diabète de type II, et des compositions.
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Designated States: AE, AG, AL, AM, AO, AT, AU, AZ, BA, BB, BG, BH, BN, BR, BW, BY, BZ, CA, CH, CL, CN, CO, CR, CU, CZ, DE, DJ, DK, DM, DO, DZ, EC, EE, EG, ES, FI, GB, GD, GE, GH, GM, GT, HN, HR, HU, ID, IL, IN, IR, IS, JO, JP, KE, KG, KH, KN, KP, KR, KW, KZ, LA, LC, LK, LR, LS, LU, LY, MA, MD, ME, MG, MK, MN, MW, MX, MY, MZ, NA, NG, NI, NO, NZ, OM, PA, PE, PG, PH, PL, PT, QA, RO, RS, RU, RW, SA, SC, SD, SE, SG, SK, SL, SM, ST, SV, SY, TH, TJ, TM, TN, TR, TT, TZ, UA, UG, US, UZ, VC, VN, ZA, ZM, ZW
African Regional Intellectual Property Organization (ARIPO) (BW, GH, GM, KE, LR, LS, MW, MZ, NA, RW, SD, SL, ST, SZ, TZ, UG, ZM, ZW)
Eurasian Patent Office (AM, AZ, BY, KG, KZ, RU, TJ, TM)
European Patent Office (EPO) (AL, AT, BE, BG, CH, CY, CZ, DE, DK, EE, ES, FI, FR, GB, GR, HR, HU, IE, IS, IT, LT, LU, LV, MC, MK, MT, NL, NO, PL, PT, RO, RS, SE, SI, SK, SM, TR)
African Intellectual Property Organization (BF, BJ, CF, CG, CI, CM, GA, GN, GQ, GW, KM, ML, MR, NE, SN, TD, TG)
Publication Language: English (EN)
Filing Language: English (EN)