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1. (WO2018101747) MARKER FOR DETECTING HIGHLY PATHOGENIC INFLUENZA VIRUS AND USE THEREOF
Latest bibliographic data on file with the International Bureau    Submit observation

Pub. No.: WO/2018/101747 International Application No.: PCT/KR2017/013843
Publication Date: 07.06.2018 International Filing Date: 29.11.2017
IPC:
G01N 33/569 (2006.01) ,G01N 33/68 (2006.01) ,G01N 33/50 (2006.01)
G PHYSICS
01
MEASURING; TESTING
N
INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
33
Investigating or analysing materials by specific methods not covered by groups G01N1/-G01N31/131
48
Biological material, e.g. blood, urine; Haemocytometers
50
Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
53
Immunoassay; Biospecific binding assay; Materials therefor
569
for micro-organisms, e.g. protozoa, bacteria, viruses
G PHYSICS
01
MEASURING; TESTING
N
INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
33
Investigating or analysing materials by specific methods not covered by groups G01N1/-G01N31/131
48
Biological material, e.g. blood, urine; Haemocytometers
50
Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
68
involving proteins, peptides or amino acids
G PHYSICS
01
MEASURING; TESTING
N
INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
33
Investigating or analysing materials by specific methods not covered by groups G01N1/-G01N31/131
48
Biological material, e.g. blood, urine; Haemocytometers
50
Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
Applicants: DANDI BIOSCIENCE INC[KR/KR]; (Hwayang-dong, Biomedical Science Bldg.) 304ho, 120, Neungdong-ro, Gwangjin-gu, Seoul 05029, KR
Inventors: KIM, Kyun-Hwan; KR
PARK, Eun Sook; KR
PARK, Yeong-Min; KR
SEONG, Baik Lin; KR
BYUN, Young Ho; KR
LEE, Hye Min; KR
Agent: LEE, Myoung-Jin; KR
Priority Data:
10-2016-015992629.11.2016KR
Title (EN) MARKER FOR DETECTING HIGHLY PATHOGENIC INFLUENZA VIRUS AND USE THEREOF
(FR) MARQUEUR POUR LA DÉTECTION D'UN VIRUS DE LA GRIPPE HAUTEMENT PATHOGÈNE ET UTILISATION ASSOCIÉE
Abstract:
(EN) The present invention relates to a marker for detecting a highly pathogenic influenza virus and a use thereof, and more particularly, to a marker for detecting a highly pathogenic influenza virus, which includes a protein mutant prepared by substituting the amino acids 68 and 69 of a PB1-F2 protein, a composition for detecting a highly pathogenic virus, which includes an agent for measuring the protein mutant, and a detection kit including the same, a method for detecting a highly pathogenic virus, which includes measuring the protein mutant, an antiviral composition against influenza A virus, which includes an inhibitor of binding between a PB1-F2 protein in which the amino acids 68 and 69 are substituted and DDX3, and a method for screening an antiviral substance against influenza A virus. In the present invention, as the correlation between a 1918 PB1-F2 protein and high pathogenicity of the virus and a molecular mechanism thereof were first identified, a protein mutant prepared by substituting the amino acids 68 and 69 in the PB1-F2 protein sequence of an influenza virus can be used as a marker for detecting a highly pathogenic virus, and a highly pathogenic virus may be effectively detected by measuring the mutant. In addition, the viral mechanism of the evasion of innate immunity by the PB1-F2 protein mutant newly identified in the present invention may provide a new understanding for developing an antiviral agent, and the antiviral composition according to the present invention may be effectively used in the development of an antiviral agent.
(FR) La présente invention concerne un marqueur pour la détection d'un virus de la grippe hautement pathogène et une utilisation associée, et plus particulièrement, un marqueur pour la détection d'un virus de la grippe hautement pathogène, qui comprend un mutant de protéine préparé par substitution des acides aminés 68 et 69 d'une protéine PB1-F2, une composition pour détecter un virus hautement pathogène, qui comprend un agent pour mesurer le mutant de protéine, et un kit de détection la comprenant, un procédé de détection d'un virus hautement pathogène, qui comprend la mesure du mutant de protéine, une composition antivirale contre le virus de la grippe A, qui comprend un inhibiteur de liaison entre une protéine PB1-F2 dans laquelle les acides aminés 68 et 69 sont substitués et DDX3, et un procédé de criblage d'une substance antivirale contre le virus de la grippe A. Dans la présente invention, la corrélation entre une protéine PB1-F2 de 1918 et une pathogénicité élevée du virus et son mécanisme moléculaire ayant été d'abord identifiée, un mutant de protéine préparé par substitution des acides aminés 68 et 69 dans la séquence de protéine PB1-F2 d'un virus de la grippe peut être utilisé en tant que marqueur pour détecter un virus hautement pathogène, et un virus hautement pathogène peut être efficacement détecté par mesure du mutant. De plus, le mécanisme viral de l'évasion du système immunitaire inné par le mutant de protéine PB1-F2 nouvellement identifié dans la présente invention peut permettre une nouvelle compréhension dans le but développer un agent antiviral, et la composition antivirale selon la présente invention peut être utilisée efficacement dans le développement d'un agent antiviral.
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Designated States: AE, AG, AL, AM, AO, AT, AU, AZ, BA, BB, BG, BH, BN, BR, BW, BY, BZ, CA, CH, CL, CN, CO, CR, CU, CZ, DE, DJ, DK, DM, DO, DZ, EC, EE, EG, ES, FI, GB, GD, GE, GH, GM, GT, HN, HR, HU, ID, IL, IN, IR, IS, JO, JP, KE, KG, KH, KN, KP, KW, KZ, LA, LC, LK, LR, LS, LU, LY, MA, MD, ME, MG, MK, MN, MW, MX, MY, MZ, NA, NG, NI, NO, NZ, OM, PA, PE, PG, PH, PL, PT, QA, RO, RS, RU, RW, SA, SC, SD, SE, SG, SK, SL, SM, ST, SV, SY, TH, TJ, TM, TN, TR, TT, TZ, UA, UG, US, UZ, VC, VN, ZA, ZM, ZW
African Regional Intellectual Property Organization (ARIPO) (BW, GH, GM, KE, LR, LS, MW, MZ, NA, RW, SD, SL, ST, SZ, TZ, UG, ZM, ZW)
Eurasian Patent Office (AM, AZ, BY, KG, KZ, RU, TJ, TM)
European Patent Office (EPO) (AL, AT, BE, BG, CH, CY, CZ, DE, DK, EE, ES, FI, FR, GB, GR, HR, HU, IE, IS, IT, LT, LU, LV, MC, MK, MT, NL, NO, PL, PT, RO, RS, SE, SI, SK, SM, TR)
African Intellectual Property Organization (BF, BJ, CF, CG, CI, CM, GA, GN, GQ, GW, KM, ML, MR, NE, SN, TD, TG)
Publication Language: English (EN)
Filing Language: English (EN)