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1. (WO2018101692) TABLET CONTAINING METFORMIN AND HMG-COA REDUCTASE INHIBITOR
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Pub. No.: WO/2018/101692 International Application No.: PCT/KR2017/013622
Publication Date: 07.06.2018 International Filing Date: 27.11.2017
IPC:
A61K 9/20 (2006.01) ,A61K 9/28 (2006.01) ,A61K 31/155 (2006.01) ,A61K 31/505 (2006.01) ,A61K 31/40 (2006.01)
A HUMAN NECESSITIES
61
MEDICAL OR VETERINARY SCIENCE; HYGIENE
K
PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
9
Medicinal preparations characterised by special physical form
20
Pills, lozenges or tablets
A HUMAN NECESSITIES
61
MEDICAL OR VETERINARY SCIENCE; HYGIENE
K
PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
9
Medicinal preparations characterised by special physical form
20
Pills, lozenges or tablets
28
Dragees; Coated pills or tablets
A HUMAN NECESSITIES
61
MEDICAL OR VETERINARY SCIENCE; HYGIENE
K
PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
31
Medicinal preparations containing organic active ingredients
13
Amines, e.g. amantadine
155
Amidines (), e.g. guanidine (H2N-C(NH)-NH2), isourea (HNC(OH)NH2), isothiourea (HNC(SH)-NH2)
A HUMAN NECESSITIES
61
MEDICAL OR VETERINARY SCIENCE; HYGIENE
K
PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
31
Medicinal preparations containing organic active ingredients
33
Heterocyclic compounds
395
having nitrogen as a ring hetero atom, e.g. guanethidine, rifamycins
495
having six-membered rings with two nitrogen atoms as the only ring hetero atoms, e.g. piperazine
505
Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim
A HUMAN NECESSITIES
61
MEDICAL OR VETERINARY SCIENCE; HYGIENE
K
PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
31
Medicinal preparations containing organic active ingredients
33
Heterocyclic compounds
395
having nitrogen as a ring hetero atom, e.g. guanethidine, rifamycins
40
having five-membered rings with one nitrogen as the only ring hetero atom, e.g. sulpiride, succinimide, tolmetin, buflomedil
Applicants:
주식회사유한양행 YUHAN CORPORATION [KR/KR]; 서울시 동작구 노량진로 74 74, Noryangjin-ro Dongjak-gu Seoul 06927, KR
Inventors:
김상호 KIM, Sang Ho; KR
김용한 KIM, Yong Han; KR
박성배 PARK, Seong Bae; KR
박융식 PARK, Yoong Sik; KR
현창근 HYUN, Chang Keun; KR
Agent:
안소영 AHN, So Young; KR
Priority Data:
10-2016-016366002.12.2016KR
Title (EN) TABLET CONTAINING METFORMIN AND HMG-COA REDUCTASE INHIBITOR
(FR) COMPRIMÉ CONTENANT DE LA METFORMINE ET UN INHIBITEUR DE HMG-COA RÉDUCTASE
(KO) 메트포르민 및 HMG-COA 환원효소 억제제를 포함하는 정제
Abstract:
(EN) The present invention provides a tablet comprising: a first layer containing metformin or a pharmaceutically acceptable salt thereof; and a second layer containing an HMG-CoA reductase inhibitor or a pharmaceutically acceptable salt thereof, wherein the first layer and/or the second layer contains glyceryl behenate. The tablet of the present invention, when prepared into a multi-layered tablet, has excellent friability and hardness, particularly has no interlayer separation phenomenon, and exhibits an equal dissolution rate compared with that of a single preparation of an active ingredient.
(FR) La présente invention concerne un comprimé comprenant : une première couche contenant de la metformine ou un sel pharmaceutiquement acceptable de celle-ci ; et une seconde couche contenant un inhibiteur de la HMG-CoA réductase ou un sel pharmaceutiquement acceptable de celui-ci, la première couche et/ou la seconde couche contenant du béhénate de glycéryle. Le comprimé de la présente invention, lorsqu'il est préparé sous la forme d'un comprimé multicouche, présente une excellente friabilité et une excellente dureté, et en particulier ne présente pas de phénomène de séparation intercouche, et présente un taux de dissolution égal à celui d'une préparation unique d'un ingrédient actif.
(KO) 본 발명은 메트포르민 또는 이의 약제학적으로 허용 가능한 염을 함유하는 제1층 및 HMG-CoA 환원효소 억제제 또는 이의 약제학적으로 허용 가능한 염을 함유하는 제2층을 포함하고, 상기 제1층 및 제2층 중 어느 하나 이상의 층은 글리세릴베헤네이트를 포함하는 정제를 제공한다. 본 발명의 정제는 다층정으로 제조시 마손도 및 경도가 우수하고, 특히 층간분리 현상이 없으며, 유효성분의 단일제와 비교하여 동등한 용출률을 나타낸다.
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Designated States: AE, AG, AL, AM, AO, AT, AU, AZ, BA, BB, BG, BH, BN, BR, BW, BY, BZ, CA, CH, CL, CN, CO, CR, CU, CZ, DE, DJ, DK, DM, DO, DZ, EC, EE, EG, ES, FI, GB, GD, GE, GH, GM, GT, HN, HR, HU, ID, IL, IN, IR, IS, JO, JP, KE, KG, KH, KN, KP, KW, KZ, LA, LC, LK, LR, LS, LU, LY, MA, MD, ME, MG, MK, MN, MW, MX, MY, MZ, NA, NG, NI, NO, NZ, OM, PA, PE, PG, PH, PL, PT, QA, RO, RS, RU, RW, SA, SC, SD, SE, SG, SK, SL, SM, ST, SV, SY, TH, TJ, TM, TN, TR, TT, TZ, UA, UG, US, UZ, VC, VN, ZA, ZM, ZW
African Regional Intellectual Property Organization (ARIPO) (BW, GH, GM, KE, LR, LS, MW, MZ, NA, RW, SD, SL, ST, SZ, TZ, UG, ZM, ZW)
Eurasian Patent Office (AM, AZ, BY, KG, KZ, RU, TJ, TM)
European Patent Office (EPO) (AL, AT, BE, BG, CH, CY, CZ, DE, DK, EE, ES, FI, FR, GB, GR, HR, HU, IE, IS, IT, LT, LU, LV, MC, MK, MT, NL, NO, PL, PT, RO, RS, SE, SI, SK, SM, TR)
African Intellectual Property Organization (BF, BJ, CF, CG, CI, CM, GA, GN, GQ, GW, KM, ML, MR, NE, SN, TD, TG)
Publication Language: Korean (KO)
Filing Language: Korean (KO)