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1. (WO2018101550) USE OF MICRORNA-188-5P FOR TREATING ALZHEIMER'S DISEASE

Pub. No.:    WO/2018/101550    International Application No.:    PCT/KR2017/003783
Publication Date: Fri Jun 08 01:59:59 CEST 2018 International Filing Date: Fri Apr 07 01:59:59 CEST 2017
IPC: A61K 48/00
A61K 31/713
Applicants: SEOUL NATIONAL UNIVERSITY R&DB FOUNDATION
서울대학교산학협력단
Inventors: KIM, Hye Sun
김혜선
LEE, Kihwan
이기환
KIM, Hyunju
김현주
Title: USE OF MICRORNA-188-5P FOR TREATING ALZHEIMER'S DISEASE
Abstract:
The present invention relates to a use of microRNA(miR)-188-5p which can be used in the treatment of Alzheimer's disease. A pharmaceutical composition, of the present invention, containing miR-188-5p as an active ingredient, inhibits the expression of an NRP2 protein when administered to a subject having Alzheimer's disease and restores the density of the decreased dendritic spines and enhances a synaptic transmission function, thereby enabling Alzheimer's disease to be effectively prevented or treated.