Some content of this application is unavailable at the moment.
If this situation persist, please contact us atFeedback&Contact
1. (WO2018101477) ENDOCYTOSIS ENHANCER FOR DRUG DELIVERY SYSTEMS
Latest bibliographic data on file with the International Bureau    Submit observation

Pub. No.: WO/2018/101477 International Application No.: PCT/JP2017/043373
Publication Date: 07.06.2018 International Filing Date: 01.12.2017
IPC:
A61K 47/42 (2017.01) ,A61K 9/107 (2006.01) ,A61K 38/16 (2006.01) ,A61K 38/22 (2006.01) ,A61K 39/395 (2006.01) ,A61K 47/24 (2006.01) ,A61P 43/00 (2006.01) ,C07K 14/435 (2006.01) ,C12Q 1/00 (2006.01)
A HUMAN NECESSITIES
61
MEDICAL OR VETERINARY SCIENCE; HYGIENE
K
PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
47
Medicinal preparations characterised by the non-active ingredients used, e.g. carriers, inert additives
30
Macromolecular compounds
42
Proteins; Polypeptides; Degradation products thereof; Derivatives thereof
A HUMAN NECESSITIES
61
MEDICAL OR VETERINARY SCIENCE; HYGIENE
K
PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
9
Medicinal preparations characterised by special physical form
10
Dispersions; Emulsions
107
Emulsions
A HUMAN NECESSITIES
61
MEDICAL OR VETERINARY SCIENCE; HYGIENE
K
PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
38
Medicinal preparations containing peptides
16
Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
A HUMAN NECESSITIES
61
MEDICAL OR VETERINARY SCIENCE; HYGIENE
K
PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
38
Medicinal preparations containing peptides
16
Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
17
from animals; from humans
22
Hormones
A HUMAN NECESSITIES
61
MEDICAL OR VETERINARY SCIENCE; HYGIENE
K
PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
39
Medicinal preparations containing antigens or antibodies
395
Antibodies; Immunoglobulins; Immune serum, e.g. antilymphocytic serum
A HUMAN NECESSITIES
61
MEDICAL OR VETERINARY SCIENCE; HYGIENE
K
PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
47
Medicinal preparations characterised by the non-active ingredients used, e.g. carriers, inert additives
06
Organic compounds
24
containing atoms other than carbon, hydrogen, halogen, oxygen, nitrogen or sulfur
A HUMAN NECESSITIES
61
MEDICAL OR VETERINARY SCIENCE; HYGIENE
P
SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
43
Drugs for specific purposes, not provided for in groups A61P1/-A61P41/108
C CHEMISTRY; METALLURGY
07
ORGANIC CHEMISTRY
K
PEPTIDES
14
Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
435
from animals; from humans
C CHEMISTRY; METALLURGY
12
BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
Q
MEASURING OR TESTING PROCESSES INVOLVING ENZYMES OR MICRO-ORGANISMS; COMPOSITIONS OR TEST PAPERS THEREFOR; PROCESSES OF PREPARING SUCH COMPOSITIONS; CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL OR ENZYMOLOGICAL PROCESSES
1
Measuring or testing processes involving enzymes or micro-organisms; Compositions therefor; Processes of preparing such compositions
Applicants:
国立大学法人埼玉大学 SAITAMA UNIVERSITY [JP/JP]; 埼玉県さいたま市桜区下大久保255 255 Shimo-Okubo, Sakura-ku, Saitama City, Saitama 3388570, JP
株式会社Quarrymen&Co. QUARRYMEN&CO. INC. [JP/JP]; 東京都世田谷区成城6-14-23 14-23, Seijo 6-chome, Setagaya-ku, Tokyo 1570066, JP
Inventors:
鈴木 美穂 SUZUKI, Miho; JP
幡野 健 HATANO Ken; JP
吉田 彰次郎 YOSHIDA Shojiro; JP
山下 靖弘 YAMASHITA Yasuhiro; JP
Agent:
特許業務法人綾船国際特許事務所 AYAFUNE INTERNATIONAL PATENTS & TRADEMARKS PATENT PROFESSIONAL CORPORATION; 東京都中央区京橋1丁目19番4号TAF京橋ビル5F TAF Kyobashi Bldg. 5th Floor, 19-4, Kyobashi 1-chome, Chuo-ku, Tokyo 1040031, JP
Priority Data:
2016-23454701.12.2016JP
Title (EN) ENDOCYTOSIS ENHANCER FOR DRUG DELIVERY SYSTEMS
(FR) ACTIVATEUR D'ENDOCYTOSE POUR DES SYSTÈMES D'ADMINISTRATION DE MÉDICAMENT
(JA) 薬物送達系用エンドサイトーシス増強剤
Abstract:
(EN) The present invention addresses the problem of providing an endocytosis enhancer comprising associates formed from a fluorescent protein. The fluorescent protein is preferably any one selected from the group consisting of a white fluorescent protein, a red fluorescent protein, a yellow fluorescent protein, a blue fluorescent protein and a green fluorescent protein. The endocytosis enhancer according to the present invention can enhance the cellular uptake of a drug, which is encapsulated in micelles each formed from a fluorescent-protein-supported carbosilane dendrimer, through endocytosis.
(FR) La présente invention aborde le problème de la fourniture d'un activateur d'endocytose comprenant des associations formées à partir d'une protéine fluorescente. La protéine fluorescente est, de préférence, une protéine quelconque choisie dans le groupe constitué par une protéine fluorescente blanche, une protéine fluorescente rouge, une protéine fluorescente jaune, une protéine fluorescente bleue et une protéine fluorescente verte. L'activateur d'endocytose selon la présente invention peut améliorer l'absorption cellulaire d'un médicament, qui est encapsulé dans des micelles formées chacune à partir d'un dendrimère carbosilane supporté par une protéine fluorescente, par endocytose.
(JA) 本発明は、蛍光タンパク質によって形成された会合体からなるエンドサイトーシス増強剤を提供することを目的とする。前記蛍光タンパク質は、白色蛍光タンパク質、赤色蛍光タンパク質、黄色蛍光タンパク質、青色蛍光タンパク質、及び緑色蛍光タンパク質からなる群から選ばれるいずれかの蛍光タンパク質であることが好ましい。 本発明のエンドサイトーシス増強剤は、蛍光タンパク質を担持させたカルボシランデンドリマーで形成されたミセルに内包された薬物の細胞内へエンドサイトーシスによる取込みを増強することができる。
Designated States: AE, AG, AL, AM, AO, AT, AU, AZ, BA, BB, BG, BH, BN, BR, BW, BY, BZ, CA, CH, CL, CN, CO, CR, CU, CZ, DE, DJ, DK, DM, DO, DZ, EC, EE, EG, ES, FI, GB, GD, GE, GH, GM, GT, HN, HR, HU, ID, IL, IN, IR, IS, JO, JP, KE, KG, KH, KN, KP, KR, KW, KZ, LA, LC, LK, LR, LS, LU, LY, MA, MD, ME, MG, MK, MN, MW, MX, MY, MZ, NA, NG, NI, NO, NZ, OM, PA, PE, PG, PH, PL, PT, QA, RO, RS, RU, RW, SA, SC, SD, SE, SG, SK, SL, SM, ST, SV, SY, TH, TJ, TM, TN, TR, TT, TZ, UA, UG, US, UZ, VC, VN, ZA, ZM, ZW
African Regional Intellectual Property Organization (ARIPO) (BW, GH, GM, KE, LR, LS, MW, MZ, NA, RW, SD, SL, ST, SZ, TZ, UG, ZM, ZW)
Eurasian Patent Office (AM, AZ, BY, KG, KZ, RU, TJ, TM)
European Patent Office (EPO) (AL, AT, BE, BG, CH, CY, CZ, DE, DK, EE, ES, FI, FR, GB, GR, HR, HU, IE, IS, IT, LT, LU, LV, MC, MK, MT, NL, NO, PL, PT, RO, RS, SE, SI, SK, SM, TR)
African Intellectual Property Organization (BF, BJ, CF, CG, CI, CM, GA, GN, GQ, GW, KM, ML, MR, NE, SN, TD, TG)
Publication Language: Japanese (JA)
Filing Language: Japanese (JA)