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1. (WO2018100628) ESTABLISHING METAL ALLERGY ANIMAL MODEL THAT IS HIGHLY SENSITIVE/SUSCEPTIVE TO METAL
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Pub. No.: WO/2018/100628 International Application No.: PCT/JP2016/085381
Publication Date: 07.06.2018 International Filing Date: 29.11.2016
Chapter 2 Demand Filed: 26.05.2017
IPC:
A01K 67/027 (2006.01) ,A01K 67/00 (2006.01) ,C12N 15/09 (2006.01) ,C12Q 1/68 (2006.01)
A HUMAN NECESSITIES
01
AGRICULTURE; FORESTRY; ANIMAL HUSBANDRY; HUNTING; TRAPPING; FISHING
K
ANIMAL HUSBANDRY; CARE OF BIRDS, FISHES, INSECTS; FISHING; REARING OR BREEDING ANIMALS, NOT OTHERWISE PROVIDED FOR; NEW BREEDS OF ANIMALS
67
Rearing or breeding animals, not otherwise provided for; New breeds of animals
027
New breeds of vertebrates
A HUMAN NECESSITIES
01
AGRICULTURE; FORESTRY; ANIMAL HUSBANDRY; HUNTING; TRAPPING; FISHING
K
ANIMAL HUSBANDRY; CARE OF BIRDS, FISHES, INSECTS; FISHING; REARING OR BREEDING ANIMALS, NOT OTHERWISE PROVIDED FOR; NEW BREEDS OF ANIMALS
67
Rearing or breeding animals, not otherwise provided for; New breeds of animals
C CHEMISTRY; METALLURGY
12
BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
N
MICRO-ORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICRO-ORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
15
Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
09
Recombinant DNA-technology
C CHEMISTRY; METALLURGY
12
BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
Q
MEASURING OR TESTING PROCESSES INVOLVING ENZYMES OR MICRO-ORGANISMS; COMPOSITIONS OR TEST PAPERS THEREFOR; PROCESSES OF PREPARING SUCH COMPOSITIONS; CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL OR ENZYMOLOGICAL PROCESSES
1
Measuring or testing processes involving enzymes or micro-organisms; Compositions therefor; Processes of preparing such compositions
68
involving nucleic acids
Applicants:
国立大学法人東北大学 TOHOKU UNIVERSITY [JP/JP]; 宮城県仙台市青葉区片平二丁目1番1号 2-1-1 Katahira, Aoba-ku, Sendai-shi, Miyagi 9808577, JP
Inventors:
小笠原 康悦 OGASAWARA Koetsu; JP
Agent:
平木 祐輔 HIRAKI Yusuke; JP
藤田 節 FUJITA Takashi; JP
田中 夏夫 TANAKA Natsuo; JP
Priority Data:
Title (EN) ESTABLISHING METAL ALLERGY ANIMAL MODEL THAT IS HIGHLY SENSITIVE/SUSCEPTIVE TO METAL
(FR) PROCÉDÉ DE CRÉATION D’UN MODÈLE ANIMAL POUR ALLERGIE AUX MÉTAUX TRÈS SENSIBLE / TRÈS RÉACTIF AUX MÉTAUX
(JA) 金属高感度・高感受性の金属アレルギー動物モデルの樹立
Abstract:
(EN) Provided are a method for establishing a metal allergy animal model that is highly sensitive/susceptive to a metal, an animal model obtained by said method, a method for cloning a gene that encodes a protein comprising a variable region and a constant region, and a cloning vector used for cloning said gene. The present invention pertains to a metal allergy transgenic non-human animal model which includes foreign DNA encoding a metal allergy specific T-cell receptor cloned from a T-cell of a non-human animal that has developed metal allergy as a result of being administered a metal.
(FR) L’invention a pour objet de fournir un procédé de création d’un modèle animal pour allergie aux métaux très sensible / très réactif aux métaux, et un modèle animal obtenu par ce procédé de création. L’invention fournit également un procédé selon lequel un gène codant une protéine constituée d’une région variable et d’une région constante, est cloné, et un vecteur de clonage mis en œuvre dans ce clonage. Plus précisément, l’invention concerne un modèle d’animal non humain transgénique pour allergie aux métaux qui contient un ADN étranger codant un récepteur de cellule T spécifique de l’allergie aux métaux cloné à partir d’une cellule T d’un animal non humain ayant développé une allergie au métal par administration d’un métal.
(JA) 金属高感度・高感受性の金属アレルギー動物モデルの樹立法及び該樹立法により得られた動物モデルの提供、並びに可変領域と定常領域からなるタンパク質をコードする遺伝子をクローニングする方法及びクローニングに用いるクローニングベクターの提供。 金属の投与により金属アレルギーを発症した非ヒト動物のT細胞からクローニングした金属アレルギー特異的T細胞受容体をコードする外来DNAを含む、金属アレルギートランスジェニック非ヒト動物モデル。
Designated States: AE, AG, AL, AM, AO, AT, AU, AZ, BA, BB, BG, BH, BN, BR, BW, BY, BZ, CA, CH, CL, CN, CO, CR, CU, CZ, DE, DJ, DK, DM, DO, DZ, EC, EE, EG, ES, FI, GB, GD, GE, GH, GM, GT, HN, HR, HU, ID, IL, IN, IR, IS, JP, KE, KG, KN, KP, KR, KW, KZ, LA, LC, LK, LR, LS, LU, LY, MA, MD, ME, MG, MK, MN, MW, MX, MY, MZ, NA, NG, NI, NO, NZ, OM, PA, PE, PG, PH, PL, PT, QA, RO, RS, RU, RW, SA, SC, SD, SE, SG, SK, SL, SM, ST, SV, SY, TH, TJ, TM, TN, TR, TT, TZ, UA, UG, US, UZ, VC, VN, ZA, ZM, ZW
African Regional Intellectual Property Organization (ARIPO) (BW, GH, GM, KE, LR, LS, MW, MZ, NA, RW, SD, SL, ST, SZ, TZ, UG, ZM, ZW)
Eurasian Patent Office (AM, AZ, BY, KG, KZ, RU, TJ, TM)
European Patent Office (EPO) (AL, AT, BE, BG, CH, CY, CZ, DE, DK, EE, ES, FI, FR, GB, GR, HR, HU, IE, IS, IT, LT, LU, LV, MC, MK, MT, NL, NO, PL, PT, RO, RS, SE, SI, SK, SM, TR)
African Intellectual Property Organization (BF, BJ, CF, CG, CI, CM, GA, GN, GQ, GW, KM, ML, MR, NE, SN, TD, TG)
Publication Language: Japanese (JA)
Filing Language: Japanese (JA)