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1. (WO2018100562) COORDINATION COMPOUNDS, SYNTHESES, NANOFORMULATION AND USE THEREOF IN ONCOLOGY

Pub. No.:    WO/2018/100562    International Application No.:    PCT/IB2017/057594
Publication Date: Fri Jun 08 01:59:59 CEST 2018 International Filing Date: Sun Dec 03 00:59:59 CET 2017
IPC: C07F 15/00
C07H 15/22
C07K 1/107
C07F 5/00
A61K 31/7008
A61K 31/295
A61K 31/27
A61K 31/401
A61P 35/00
Applicants: NARDON, Chiara
FREGONA, Dolores
BRUSTOLIN, Leonardo
PETTENUZZO, Nicolò
Inventors: NARDON, Chiara
FREGONA, Dolores
BRUSTOLIN, Leonardo
PETTENUZZO, Nicolò
Title: COORDINATION COMPOUNDS, SYNTHESES, NANOFORMULATION AND USE THEREOF IN ONCOLOGY
Abstract:
The present invention relates to mononuclear and dinuclear coordination compounds of Ru and Ga, pharmaceutical formulations based thereof, the relative method of synthesis and encapsulation of the compounds in macromolecules, supramolecular aggregates or nanostructures, as well as their use for the diagnosis and/or treatment of neoplasia. Advantageously, such coordination compounds and/or formulations may contain carbohydrates which act as "cancer-targeting moieties" thereby increasing therapeutic selectivity. Said compounds and formulations are characterized by a promising toxicological profile, a remarkable and highly-selective anti-cancer activity, as well as stability and solubility in the physiological means.