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1. (WO2018100561) COORDINATION COMPOUNDS, SYNTHESES, NANOFORMULATION AND USE THEREOF IN ONCOLOGY
Latest bibliographic data on file with the International Bureau    Submit observation

Pub. No.:    WO/2018/100561    International Application No.:    PCT/IB2017/057593
Publication Date: 07.06.2018 International Filing Date: 02.12.2017
IPC:
C07F 1/12 (2006.01), A61K 31/401 (2006.01), A61K 31/44 (2006.01), A61K 31/5377 (2006.01), A61K 31/7008 (2006.01), C07H 5/06 (2006.01), C07H 15/14 (2006.01), C07H 15/22 (2006.01), C07K 1/107 (2006.01), A61P 35/00 (2006.01)
Applicants: NARDON, Chiara [IT/IT]; (IT).
FREGONA, Dolores [IT/IT]; (IT).
BRUSTOLIN, Leonardo [IT/IT]; (IT).
PETTENUZZO, Nicolò [IT/IT]; (IT)
Inventors: NARDON, Chiara; (IT).
FREGONA, Dolores; (IT).
BRUSTOLIN, Leonardo; (IT).
PETTENUZZO, Nicolò; (IT)
Priority Data:
102016000122363 02.12.2016 IT
Title (EN) COORDINATION COMPOUNDS, SYNTHESES, NANOFORMULATION AND USE THEREOF IN ONCOLOGY
(FR) COMPOSÉS DE COORDINATION, SYNTHÈSES, NANOFORMULATION ET LEUR UTILISATION EN ONCOLOGIE
Abstract: front page image
(EN)The present invention relates to mononuclear coordination compounds of Au and Cu, pharmaceutical formulations based thereof, the relative method of synthesis and encapsulation of the compounds in macromolecules, supramolecular aggregates or nanostructures, as well as their use for the diagnosis and/or treatment of neoplasia. Advantageously, such coordination compounds and/or formulations may contain carbohydrates which act as "cancer-targeting moieties" thereby increasing therapeutic selectivity. Said compounds and formulations are characterized by a promising toxicological profile, a remarkable and highly-selective anti-cancer activity, as well as stability and solubility in the physiological means.
(FR)La présente invention concerne des composés de coordination mononucléaires d'Au et de Cu, des formulations pharmaceutiques à base de ceux-ci, le procédé relatif de synthèse et d'encapsulation des composés dans des macromolécules, des agrégats supramoléculaires ou des nanostructures, ainsi que leur utilisation pour le diagnostic et/ou le traitement de la néoplasie. De manière avantageuse, de tels composés et/ou formulations de coordination peuvent contenir des glucides qui agissent en tant que "fractions ciblant le cancer", ce qui permet d'augmenter la sélectivité thérapeutique. Lesdits composés et formulations sont caractérisés par un profil toxicologique prometteur, une activité anticancéreuse remarquable et hautement sélective, ainsi qu'une stabilité et une solubilité dans des milieux physiologiques.
Designated States: AE, AG, AL, AM, AO, AT, AU, AZ, BA, BB, BG, BH, BN, BR, BW, BY, BZ, CA, CH, CL, CN, CO, CR, CU, CZ, DE, DJ, DK, DM, DO, DZ, EC, EE, EG, ES, FI, GB, GD, GE, GH, GM, GT, HN, HR, HU, ID, IL, IN, IR, IS, JO, JP, KE, KG, KH, KN, KP, KR, KW, KZ, LA, LC, LK, LR, LS, LU, LY, MA, MD, ME, MG, MK, MN, MW, MX, MY, MZ, NA, NG, NI, NO, NZ, OM, PA, PE, PG, PH, PL, PT, QA, RO, RS, RU, RW, SA, SC, SD, SE, SG, SK, SL, SM, ST, SV, SY, TH, TJ, TM, TN, TR, TT, TZ, UA, UG, US, UZ, VC, VN, ZA, ZM, ZW.
African Regional Intellectual Property Organization (BW, GH, GM, KE, LR, LS, MW, MZ, NA, RW, SD, SL, ST, SZ, TZ, UG, ZM, ZW)
Eurasian Patent Organization (AM, AZ, BY, KG, KZ, RU, TJ, TM)
European Patent Office (AL, AT, BE, BG, CH, CY, CZ, DE, DK, EE, ES, FI, FR, GB, GR, HR, HU, IE, IS, IT, LT, LU, LV, MC, MK, MT, NL, NO, PL, PT, RO, RS, SE, SI, SK, SM, TR)
African Intellectual Property Organization (BF, BJ, CF, CG, CI, CM, GA, GN, GQ, GW, KM, ML, MR, NE, SN, TD, TG).
Publication Language: English (EN)
Filing Language: English (EN)