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1. (WO2018100540) HYDROPHILIC FLUORINATED MOLECULES FOR LIPOSOMAL 19F MRI PROBES WITH UNIQUE MR SIGNATURES

Pub. No.:    WO/2018/100540    International Application No.:    PCT/IB2017/057555
Publication Date: Fri Jun 08 01:59:59 CEST 2018 International Filing Date: Fri Dec 01 00:59:59 CET 2017
IPC: A61K 9/10
A61K 49/18
Applicants: TEXAS CHILDREN'S HOSPITAL
Inventors: ANNAPRAGADA, Ananth
TANIFUM, Eric A.
Title: HYDROPHILIC FLUORINATED MOLECULES FOR LIPOSOMAL 19F MRI PROBES WITH UNIQUE MR SIGNATURES
Abstract:
Readily available hydrophilic and small organofluorine moieties were condensed via "click chemistry" to generate nonionic hydrophilic fluorinated molecules with unique 19F MR signatures. These were used to fabricate stable liposome formulations for imaging various tissue types. This approach was tailored to exploit the broad spectrum of organic 19F molecular species and to generate probes with distinct 19F MRI signatures for simultaneous assessment of multiple molecular targets within the same target volume.