The invention relates to an orthopedic locking screw, an orthopedic locking system, and a method for manufacturing an orthopedic locking screw. The orthopedic locking screw may be used for locking an intramedullary nail. The orthopedic locking screw comprises a screw shaft. The screw shaft comprises a recess. The recess extends at least partially along a longitudinal axis of the screw shaft. The recess extends at least partially along a chord of a cross section of the screw shaft. A surface of a circular segment comprising the chord is at least partially provided with a threaded portion.