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1. (WO2018100403) COMBINATION OF PARSTATIN 1-26 AND EXENATIDE
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Pub. No.: WO/2018/100403 International Application No.: PCT/GR2017/000068
Publication Date: 07.06.2018 International Filing Date: 04.12.2017
IPC:
A61K 38/17 (2006.01) ,A61K 38/26 (2006.01) ,A61P 9/10 (2006.01)
A HUMAN NECESSITIES
61
MEDICAL OR VETERINARY SCIENCE; HYGIENE
K
PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
38
Medicinal preparations containing peptides
16
Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
17
from animals; from humans
A HUMAN NECESSITIES
61
MEDICAL OR VETERINARY SCIENCE; HYGIENE
K
PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
38
Medicinal preparations containing peptides
16
Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
17
from animals; from humans
22
Hormones
26
Glucagons
A HUMAN NECESSITIES
61
MEDICAL OR VETERINARY SCIENCE; HYGIENE
P
SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
9
Drugs for disorders of the cardiovascular system
10
for treating ischaemic or atherosclerotic diseases, e.g. antianginal drugs, coronary vasodilators, drugs for myocardial infarction, retinopathy, cerebrovascula insufficiency, renal arteriosclerosis
Applicants:
TSOPANOGLOU, Nikolaos [GR/GR]; GR
MARAGOUDAKIS, Michael [GR/GR]; GR
UNIVERSITY OF PATRAS [GR/GR]; 26504 Rio Patras, GR
Inventors:
TSOPANOGLOU, Nikolaos; GR
MARAGOUDAKIS, Michael; GR
Agent:
CHANDANOU, Alexandra; 11 K. Varnali Str. 152 33 Athens, GR
Priority Data:
2016010061802.12.2016GR
Title (EN) COMBINATION OF PARSTATIN 1-26 AND EXENATIDE
(FR) COMBINAISON DE PARSTATINE 1-26 ET D'EXÉNATIDE
Abstract:
(EN) The present invention provides a combination comprising (i) parstatin peptide 1 - 26, or a functional derivative or analogue, or a pharmaceutically acceptable salt thereof; and (ii) exenatide, or a functional derivative or analogue, or a pharmaceutically acceptable salt thereof. Said combination is suitable for cardioprotection and for treating and/or preventing ischemia and/or reperfusion injury. Further aspects of the invention relate to pharmaceutical products and pharmaceutical compositions comprising said combinations according to the invention, and methods of treatment using the same.
(FR) La présente invention concerne une combinaison comprenant (i) un peptide de parstatine 1-26, ou un dérivé ou un analogue fonctionnel, ou un sel pharmaceutiquement acceptable de celui-ci; et (ii) un exénatide, ou un dérivé ou analogue fonctionnel, ou un sel pharmaceutiquement acceptable de celui-ci. Cette combinaison est utile pour la cardioprotection et pour le traitement et/ou la prévention de l'ischémie et/ou des lésions de reperfusion. D'autres aspects de l'invention concernent des produits et des compositions pharmaceutiques comprenant lesdites combinaisons selon l'invention, ainsi que des méthodes de traitement les utilisant.
Designated States: AE, AG, AL, AM, AO, AT, AU, AZ, BA, BB, BG, BH, BN, BR, BW, BY, BZ, CA, CH, CL, CN, CO, CR, CU, CZ, DE, DJ, DK, DM, DO, DZ, EC, EE, EG, ES, FI, GB, GD, GE, GH, GM, GT, HN, HR, HU, ID, IL, IN, IR, IS, JO, JP, KE, KG, KH, KN, KP, KR, KW, KZ, LA, LC, LK, LR, LS, LU, LY, MA, MD, ME, MG, MK, MN, MW, MX, MY, MZ, NA, NG, NI, NO, NZ, OM, PA, PE, PG, PH, PL, PT, QA, RO, RS, RU, RW, SA, SC, SD, SE, SG, SK, SL, SM, ST, SV, SY, TH, TJ, TM, TN, TR, TT, TZ, UA, UG, US, UZ, VC, VN, ZA, ZM, ZW
African Regional Intellectual Property Organization (ARIPO) (BW, GH, GM, KE, LR, LS, MW, MZ, NA, RW, SD, SL, ST, SZ, TZ, UG, ZM, ZW)
Eurasian Patent Office (AM, AZ, BY, KG, KZ, RU, TJ, TM)
European Patent Office (EPO) (AL, AT, BE, BG, CH, CY, CZ, DE, DK, EE, ES, FI, FR, GB, GR, HR, HU, IE, IS, IT, LT, LU, LV, MC, MK, MT, NL, NO, PL, PT, RO, RS, SE, SI, SK, SM, TR)
African Intellectual Property Organization (BF, BJ, CF, CG, CI, CM, GA, GN, GQ, GW, KM, ML, MR, NE, SN, TD, TG)
Publication Language: English (EN)
Filing Language: English (EN)