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1. (WO2018100370) METHODS AND SYSTEMS FOR CHARACTERIZING ANALYTES USING NANOPORES



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INTERNATIONAL SEARCH REPORT (ISR)
Part 1:  1  2  3  4  5  6          Part 2:  A  B  C  D  E 
International application No. Applicant's or agent's file reference
PCT/GB2017/053603 N409733WO
International filing date (day/month/year) (Earliest) Priority Date (day/month/year)
29 November 2017 01 December 2016
Applicant
OXFORD NANOPORE TECHNOLOGIES LIMITED
FOR FURTHER ACTION: See Form PCT/ISA/220 as well as, where applicable, item 5 below.
This international search report has been prepared by this International Searching Authority and is transmitted to the applicant according to Article 18. A copy is being transmitted to the International Bureau.
It is also accompanied by a copy of each prior art document cited in this report.
1. Basis of the report
a. With regard to the language, the international search was carried out on the basis of:
the international application in the language in which it was filed.
a translation of the international application into                                          which is the language of a translation furnished for the purposes of international search (Rules 12.3(a) and 23.1(b)).
b.
This international search report has been established taking into account the rectification of an obvious mistake authorized by or notified to this Authority under Rule 91 (Rule 43.6bis(a)).
c.
1. With regard to any nucleotide and/or amino acid sequence disclosed in the international application, the international search was carried out on the basis of a sequence listing:
a. forming part of the international application as filed:
in the form of an Annex C/ST.25 text file.
on paper or in the form of an image file.
b. furnished together with the international application under PCT Rule 13ter.1(a) for the purposes of international search only in the form of an Annex C/ST.25 text file.
c. furnished subsequent to the international filing date for the purposes of international search only:
in the form of an Annex C/ST.25 text file (Rule 13ter.1(a)).
on paper or in the form of an image file (Rule 13ter.1(b) and Administrative Instructions, Section 713).
2.
In addition, in the case that more than one version or copy of a sequence listing has been filed or furnished, the required statements that the information in the subsequent or additional copies is identical to that forming part of the application as filed or does not go beyond the application as filed, as appropriate, were furnished.
3.
Additional comments:
2. Certain claims were found unsearchable
3. Unity of invention is lacking
This International Searching Authority found multiple inventions in this international application, as follows:
1. claims: 1-38, 49
Methods and products relating to a nanopore to which is attached a tag which binds to one strand of a double-stranded nucleic acid.
2. claims: 50, 51, 65-67
Methods and products relating to a nanopore to which is attached a plurality of tags whereby each strand of a double stranded nucleic acid is bound to one or more tags.
3. claims: 52-56
System comprising a nanopore in a membrane wherein the outer rim of the nanopore comprises at least one tag and whereby each of different analytes binds to the at least one tag.
4. claims: 68-71
Method for sequentially translocating two non-covalently bound molecules through a nanopore whereby one strand is translocated through the pore thereby exposing a binding site on the second strand to which is then captured by a tag on the pore.
5. claims: 39-48
Methods and products relating to a nanopore to which is conjugated at least one nucleic acid that is complementary to the adaptor.
6. claims: 57-64, 72, 73
Methods of characterizing polynucleotides involving a transmembrane (nano)pore that are not linked to the systems or complexes of the other inventions.
1.
As all required additional search fees were timely paid by the applicant, this international search report covers all searchable claims.
2.
As all searchable claims could be searched without effort justifying additional fees, this Authority did not invite payment of additional fees.
3.
As only some of the required additional search fees were timely paid by the applicant, this international search report covers only those claims for which fees were paid, specifically claims Nos.:
4.
No required additional search fees were timely paid by the applicant. Consequently, this international search report is restricted to the invention first mentioned in the claims; it is covered by claims Nos.: 1-38, 49
Remark on Protest
The additional search fees were accompanied by the applicant’s protest and, where applicable, the payment of a protest fee.
The additional search fees were accompanied by the applicant’s protest but the applicable protest fee was not paid within the time limit specified in the invitation.
No protest accompanied the payment of additional search fees.
4. Title of the invention
The text is approved as submitted by the applicant.
The text has been established by this Authority to read as follows:
5. Abstract
The text is approved as submitted by the applicant.
The text has been established, according to Rule 38.2, by this Authority as it appears in Box No. IV. The applicant may, within one month from the date of mailing of this international search report, submit comments to this Authority.
6. Drawings
a.
The figure of the drawings to be published with the abstract is Figure No.     10    
as suggested by the applicant.
as selected by this Authority, because the applicant failed to suggest a figure.
as selected by this Authority, because this figure better characterizes the invention.
b.
none of the figures is to be published with the abstract.

A. CLASSIFICATION OF SUBJECT MATTER

     C12Q 1/6869 (2018.01)i
According to International Patent Classification (IPC) or to both national classification and IPC

B. FIELDS SEARCHED

Minimum documentation searched (classification system followed by classification symbols):
     C12Q
Documentation searched other than minimum documentation to the extent that such documents are included in the fields searched:
Electronic data base consulted during the international search (name of data base and, where practicable, search terms used):
EPO-Internal, WPI Data, BIOSIS, CHEM ABS Data, EMBASE, FSTA

C. DOCUMENTS CONSIDERED TO BE RELEVANT

Category* Citation of document, with indication, where appropriate, of the relevant passages Relevant to claim No.
(1)
X
WO 2016099673 A1 (GENIA TECHNOLOGIES INC [US]) 23 June 2016 (2016-06-23)
1,49
Y
claim 1; Figs 2, 3; par. 21
2-38
(2)
X
WO 2013185137 A1 (PACIFIC BIOSCIENCES CALIFORNIA [US]) 12 December 2013 (2013-12-12)
1,49
Y
par. 48, 54, 60; claim 1; Figs. 1-4
2-38
(3)
A
WO 2013153359 A1 (OXFORD NANOPORE TECH LTD [GB]) 17 October 2013 (2013-10-17)
1-38,49
Fig. 1
(4)
A
WO 2014074922 A1 (STRATOS GENOMICS INC [US]) 15 May 2014 (2014-05-15)
1-38,49
Fig. 3
(5)
A
HOWORKA S ET AL, "Sequence-specific detection of individual DNA strands using engineered nanopores", NATURE BIOTECHNOLOGY (ADVANCE ONLINE PUBLICATION), GALE GROUP INC,Vol. 19, No. 7, 01 July 2001 (2001-07-01), page 636-639,
XP002510816
1-38,49
Fig. 1
(6)
A
STEFAN HOWORKA ET AL, "Probing Distance and Electrical Potential within a Protein Pore with Tethered DNA", BIOPHYSICAL JOURNAL,Vol. 83, No. 6, 01 December 2002 (2002-12-01), page 3202-3210,
XP055036488
1-38,49
Fig. 1 and 2
*
Special categories of cited documents:
"A"
document defining the general state of the art which is not considered to be of particular relevance
"E"
earlier application or patent but published on or after the international filing date
"L"
document which may throw doubts on priority claim(s) or which is cited to establish the publication date of another citation or other special reason (as specified)
"O"
document referring to an oral disclosure, use, exhibition or other means
"P"
document published prior to the international filing date but later than the priority date claimed
"T"
later document published after the international filing date or priority date and not in conflict with the application but cited to understand the principle or theory underlying the invention
"X"
document of particular relevance; the claimed invention cannot be considered novel or cannot be considered to involve an inventive step when the document is taken alone
"Y"
document of particular relevance; the claimed invention cannot be considered to involve an inventive step when the document is combined with one or more other such documents, such combination being obvious to a person skilled in the art
"&"
document member of the same patent family

D. INFORMATION ON PATENT FAMILY MEMBERS

Patent document cited in search report Publication date
(day/month/year)
Patent family member(s) Publication date
(day/month/year)
WO 2016099673 A1
23 June 2016
CA 2977798 A1
CN 107533030 A
EP 3234577 A1
JP 2018501484 A
US 2016178577 A1
US 2017199150 A1
WO 2016099673 A1
23 June 2016
02 January 2018
25 October 2017
18 January 2018
23 June 2016
13 July 2017
23 June 2016
WO 2013185137 A1
12 December 2013
GB 2517875 A
US 2013327644 A1
US 2015167075 A1
US 2016010148 A1
US 2016011169 A1
WO 2013185137 A1
04 March 2015
12 December 2013
18 June 2015
14 January 2016
14 January 2016
12 December 2013
WO 2013153359 A1
17 October 2013
AU 2013246702 A1
CA 2869546 A1
CN 104350067 A
EP 2836506 A1
EP 3192804 A1
JP 6271505 B2
JP 2015514128 A
KR 20150003272 A
US 2015068904 A1
WO 2013153359 A1
16 October 2014
17 October 2013
11 February 2015
18 February 2015
19 July 2017
31 January 2018
18 May 2015
08 January 2015
12 March 2015
17 October 2013
WO 2014074922 A1
15 May 2014
CA 2890515 A1
EP 2917732 A1
US 2014134618 A1
US 2017314062 A1
WO 2014074922 A1
15 May 2014
16 September 2015
15 May 2014
02 November 2017
15 May 2014
Name and mailing address of the ISA/:
European Patent Office
P.B. 5818, Patentlaan 2, 2280 HV Rijswijk,
Netherlands
Telephone No. (+31-70)340-2040
Facsimile No. (+31-70)340-3016
Date of the actual completion of the international search:
02 February 2018
Date of mailing of the international search report:
06 April 2018
Authorized officer:
Leber, Thomas
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