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1. (WO2018100159) BACTERIAL GLUTAMINYL CYCLASES AND INHIBITORS THEREOF FOR USE IN THE TREATMENT OF PERIODONTITIS
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Pub. No.: WO/2018/100159 International Application No.: PCT/EP2017/081190
Publication Date: 07.06.2018 International Filing Date: 01.12.2017
IPC:
C12N 9/10 (2006.01) ,C12N 15/54 (2006.01) ,A61P 31/04 (2006.01) ,C07D 471/04 (2006.01)
C CHEMISTRY; METALLURGY
12
BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
N
MICRO-ORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICRO-ORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
9
Enzymes, e.g. ligases (6.); Proenzymes; Compositions thereof; Processes for preparing, activating, inhibiting, separating, or purifying enzymes
10
Transferases (2.)
C CHEMISTRY; METALLURGY
12
BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
N
MICRO-ORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICRO-ORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
15
Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
09
Recombinant DNA-technology
11
DNA or RNA fragments; Modified forms thereof
52
Genes encoding for enzymes or proenzymes
54
Transferases (2)
A HUMAN NECESSITIES
61
MEDICAL OR VETERINARY SCIENCE; HYGIENE
P
SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
31
Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
04
Antibacterial agents
C CHEMISTRY; METALLURGY
07
ORGANIC CHEMISTRY
D
HETEROCYCLIC COMPOUNDS
471
Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/-C07D463/251
02
in which the condensed system contains two hetero rings
04
Ortho-condensed systems
Applicants:
FRAUNHOFER-GESELLSCHAFT ZUR FÖRDERUNG DER ANGEWANDTEN FORSCHUNG E.V. [DE/DE]; Hansastraße 27c 80686 München, DE
Inventors:
BUCHHOLZ, Mirko; DE
TAUDTE, Nadine; DE
POTEMPA, Jan; PL
EICK, Sigrun; CH
RAHFELD, Jens-Ulrich; DE
DEMUTH, Hans-Ulrich; DE
Agent:
HOFFMANN EITLE PATENT- UND RECHTSANWÄLTE PARTMBB; Arabellastraße 30 81925 Munich, DE
ZANGS, Rainer E.; DE
KINDLER, Matthias; DE
FRANK, Veit Peter; DE
POLZ, Leo; DE
STEIN-DRÄGER, Christiane; DE
AVERY, Stephen John; DE
LETHEM, David James; DE
MARSH, Roy David; DE
MITCHELL, Alan; DE
FURLONG, Christopher Heinrich; DE
BAUSCH, Thorsten; DE
TAORMINO, Joseph Paul; DE
KLUSMANN, Peter; DE
SCHWEIGHART, Peter; DE
WOLF, Matthias; DE
SIEGERT, Georg; DE
MAYRHOFER, Stefan; DE
STRATMANN, Klemens; DE
WIEDEMANN, Peter; DE
VON KUROWSKI, Lorenz; DE
BECHER, Claus Thomas; DE
SPILGIES, Jan-Hendrik; DE
RENKEN, Joachim; DE
ENGELHARD, Elisabeth; DE
BACHELIN, Karl Martin Raimund; DE
DISSER, Stephan; DE
VAN BOUWELEN, Franciscus Maria; DE
FÜCHSLE, Kathrin; DE
CIESLA, Ulrike; DE
SCHÖN, Anne Katrin; DE
VOCKE, Henrik; DE
GÖRG, Andreas; DE
GARBERG, Morten; DE
RUSSELL, John Alistair; DE
SPROSTON, David; DE
THIRLWELL, Karen; DE
SCHEIBLE, Dominik; DE
VOS, Bianca-Lucia; DE
DOUXCHAMPS, Nicolas; DE
STEFFERL, Andreas; DE
GOLLER, Daniel; DE
PRUSS, Timo; DE
WERNER-JONES, Leonard L.; DE
BACCELLI, Michele; DE
MÜLLER, Markus Georg; DE
MUNCKE, Nadja; DE
CORNEO, Giovanni; DE
STREGE, Christine; DE
DRAGOSAVAC, Marko; DE
BIRKETT, Matthew; DE
ZILLIES, Jan Carl; DE
GROHS, Daniel; DE
MULHERN, Declan; DE
GRIMM, Stephan; DE
TILLMANN, Volker; DE
OGLE, James Matthew; DE
GLAS, Johannes Dominik; DE
STEINMÜLLER, Stephan; DE
BENEDETTO, Marco; DE
LEVINE, Benjamin; DE
JONES, Mark A. G.; DE
GRAEBER, Jens; DE
FUSTER, Gustavo; DE
ESSER, Axel T.; DE
SCHIEREN, Roland; DE
RECKENTHÄLER, Peter; DE
CATANIA, Olivier; DE
DÖRFEL, Katrin; DE
WEINMANN, Lasse; DE
SASSE, Stefan; DE
MACHOTTA, Axel; DE
SCHREIBER, Christian; DE
WYDER, Thomas; DE
WEIGEL-KRUSEMARCK, Michaela; DE
MÜLLER, Michael; DE
LEWIS, Debra Louise; DE
PAETZOLD, Helge; DE
SPIRKOSKA, Danche; DE
Priority Data:
16201913.702.12.2016EP
Title (EN) BACTERIAL GLUTAMINYL CYCLASES AND INHIBITORS THEREOF FOR USE IN THE TREATMENT OF PERIODONTITIS
(FR) GLUTAMINYL CYCLASES BACTÉRIENNES ET LEURS INHIBITEURS DESTINÉS À ÊTRE UTILISÉS DANS LE TRAITEMENT DE LA PARODONTITE
Abstract:
(EN) The present invention relates to bacterial glutaminyl cyclases and inhibitors thereof for use in the treatment of periodontitis and related conditions, and provides a bacterial glutaminyl cyclase (bacQC); an antibody which recognizes the bacQC, a method for identifying an inhibitor of the bacQC; a compound according to Formula (I); a pharmaceutical composition comprising a bacQC inhibitor compound; a bacQC inhibitor compound and/or a pharmaceutical composition for use in a method for treatment of the human or animal body, for use in a method for therapy or prophylaxis of a bacterial infection, and for use in a method for therapy and/or prophylaxis of an acute, chronic or recurrent periodontal disease.
(FR) La présente invention concerne des glutaminyl cyclases bactériennes et leurs inhibiteurs destinés à être utilisés dans le traitement de la parodontite et d'états apparentés, et fournit une glutaminyl cyclase bactérienne (bacQC); un anticorps qui reconnaît la bacQC, un procédé d'identification d'un inhibiteur de la bacQC; un composé selon la formule (I); une composition pharmaceutique comprenant un composé inhibiteur de bacQC; un composé inhibiteur de bacQC et/ou une composition pharmaceutique destinés à être utilisés dans une méthode de traitement du corps humain ou animal, destinés à être utilisés dans une méthode de thérapie ou de prophylaxie d'une infection bactérienne, et destinés à être utilisés dans une méthode de thérapie et/ou de prophylaxie d'une maladie parodontale aiguë, chronique ou récurrente.
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Designated States: AE, AG, AL, AM, AO, AT, AU, AZ, BA, BB, BG, BH, BN, BR, BW, BY, BZ, CA, CH, CL, CN, CO, CR, CU, CZ, DE, DJ, DK, DM, DO, DZ, EC, EE, EG, ES, FI, GB, GD, GE, GH, GM, GT, HN, HR, HU, ID, IL, IN, IR, IS, JO, JP, KE, KG, KH, KN, KP, KR, KW, KZ, LA, LC, LK, LR, LS, LU, LY, MA, MD, ME, MG, MK, MN, MW, MX, MY, MZ, NA, NG, NI, NO, NZ, OM, PA, PE, PG, PH, PL, PT, QA, RO, RS, RU, RW, SA, SC, SD, SE, SG, SK, SL, SM, ST, SV, SY, TH, TJ, TM, TN, TR, TT, TZ, UA, UG, US, UZ, VC, VN, ZA, ZM, ZW
African Regional Intellectual Property Organization (ARIPO) (BW, GH, GM, KE, LR, LS, MW, MZ, NA, RW, SD, SL, ST, SZ, TZ, UG, ZM, ZW)
Eurasian Patent Office (AM, AZ, BY, KG, KZ, RU, TJ, TM)
European Patent Office (EPO) (AL, AT, BE, BG, CH, CY, CZ, DE, DK, EE, ES, FI, FR, GB, GR, HR, HU, IE, IS, IT, LT, LU, LV, MC, MK, MT, NL, NO, PL, PT, RO, RS, SE, SI, SK, SM, TR)
African Intellectual Property Organization (BF, BJ, CF, CG, CI, CM, GA, GN, GQ, GW, KM, ML, MR, NE, SN, TD, TG)
Publication Language: English (EN)
Filing Language: English (EN)