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1. (WO2018100060) SYNTENIN INHIBITORS AND USES THEREOF
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Pub. No.: WO/2018/100060 International Application No.: PCT/EP2017/080978
Publication Date: 07.06.2018 International Filing Date: 30.11.2017
IPC:
C07K 7/06 (2006.01) ,A61K 38/08 (2006.01) ,A61K 38/10 (2006.01) ,C07K 7/08 (2006.01) ,C07K 19/00 (2006.01) ,G01N 33/574 (2006.01) ,G01N 33/68 (2006.01)
C CHEMISTRY; METALLURGY
07
ORGANIC CHEMISTRY
K
PEPTIDES
7
Peptides having 5 to 20 amino acids in a fully defined sequence; Derivatives thereof
04
Linear peptides containing only normal peptide links
06
having 5 to 11 amino acids
A HUMAN NECESSITIES
61
MEDICAL OR VETERINARY SCIENCE; HYGIENE
K
PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
38
Medicinal preparations containing peptides
04
Peptides having up to 20 amino acids in a fully defined sequence; Derivatives thereof
08
Peptides having 5 to 11 amino acids
A HUMAN NECESSITIES
61
MEDICAL OR VETERINARY SCIENCE; HYGIENE
K
PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
38
Medicinal preparations containing peptides
04
Peptides having up to 20 amino acids in a fully defined sequence; Derivatives thereof
10
Peptides having 12 to 20 amino acids
C CHEMISTRY; METALLURGY
07
ORGANIC CHEMISTRY
K
PEPTIDES
7
Peptides having 5 to 20 amino acids in a fully defined sequence; Derivatives thereof
04
Linear peptides containing only normal peptide links
08
having 12 to 20 amino acids
C CHEMISTRY; METALLURGY
07
ORGANIC CHEMISTRY
K
PEPTIDES
19
Hybrid peptides
G PHYSICS
01
MEASURING; TESTING
N
INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
33
Investigating or analysing materials by specific methods not covered by groups G01N1/-G01N31/131
48
Biological material, e.g. blood, urine; Haemocytometers
50
Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
53
Immunoassay; Biospecific binding assay; Materials therefor
574
for cancer
G PHYSICS
01
MEASURING; TESTING
N
INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
33
Investigating or analysing materials by specific methods not covered by groups G01N1/-G01N31/131
48
Biological material, e.g. blood, urine; Haemocytometers
50
Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
68
involving proteins, peptides or amino acids
Applicants:
UNIVERSITY OF COPENHAGEN [DK/DK]; Nørregade 10 1165 Copenhagen K, DK
Inventors:
STRØMGAARD, Kristian; DK
HAUGAARD-KEDSTRÖM, Linda; SE
ALBERTSEN, Louise; DK
Agent:
HØIBERG P/S; Adelgade 12 1304 Copenhagen K, DK
Priority Data:
PA 2016 7094830.11.2016DK
Title (EN) SYNTENIN INHIBITORS AND USES THEREOF
(FR) INHIBITEURS DE LA SYNTÉNINE ET LEURS APPLICATIONS
Abstract:
(EN) The present invention relates to peptides and peptide analogues with high affinity for the PDZ domains of syntenin. The peptide or peptide analog interacts with syntenin, blocking the native protein-protein interactions between syntenin and its natural Iigands. The invention furthermore relates to the therapeutic use of these peptides and peptide analogues in prevention and/or treatment of neoplastic disorders, as well as to the use for diagnosing a neoplastic disorder.
(FR) La présente invention concerne des peptides et des analogues peptidiques ayant une affinité élevée pour les domaines PDZ de la synténine. Le peptide ou l'analogue peptidique interagit avec la synténine, bloquant les interactions protéine-protéine native entre la synténine et ses ligands naturels. L'invention concerne en outre l'utilisation thérapeutique de ces peptides et analogues peptidiques dans la prévention et/ou le traitement de troubles néoplasiques, ainsi que l'utilisation pour diagnostiquer un trouble néoplasique.
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Designated States: AE, AG, AL, AM, AO, AT, AU, AZ, BA, BB, BG, BH, BN, BR, BW, BY, BZ, CA, CH, CL, CN, CO, CR, CU, CZ, DE, DJ, DK, DM, DO, DZ, EC, EE, EG, ES, FI, GB, GD, GE, GH, GM, GT, HN, HR, HU, ID, IL, IN, IR, IS, JO, JP, KE, KG, KH, KN, KP, KR, KW, KZ, LA, LC, LK, LR, LS, LU, LY, MA, MD, ME, MG, MK, MN, MW, MX, MY, MZ, NA, NG, NI, NO, NZ, OM, PA, PE, PG, PH, PL, PT, QA, RO, RS, RU, RW, SA, SC, SD, SE, SG, SK, SL, SM, ST, SV, SY, TH, TJ, TM, TN, TR, TT, TZ, UA, UG, US, UZ, VC, VN, ZA, ZM, ZW
African Regional Intellectual Property Organization (ARIPO) (BW, GH, GM, KE, LR, LS, MW, MZ, NA, RW, SD, SL, ST, SZ, TZ, UG, ZM, ZW)
Eurasian Patent Office (AM, AZ, BY, KG, KZ, RU, TJ, TM)
European Patent Office (EPO) (AL, AT, BE, BG, CH, CY, CZ, DE, DK, EE, ES, FI, FR, GB, GR, HR, HU, IE, IS, IT, LT, LU, LV, MC, MK, MT, NL, NO, PL, PT, RO, RS, SE, SI, SK, SM, TR)
African Intellectual Property Organization (BF, BJ, CF, CG, CI, CM, GA, GN, GQ, GW, KM, ML, MR, NE, SN, TD, TG)
Publication Language: English (EN)
Filing Language: English (EN)