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1. (WO2018100008) PROCESS FOR THE PREPARATION OF FREEZE-DRIED 2-[(3-AMINOPROPYL)AMINO]ETHANETHIOL FORMULATION
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Pub. No.: WO/2018/100008 International Application No.: PCT/EP2017/080881
Publication Date: 07.06.2018 International Filing Date: 29.11.2017
IPC:
C07C 319/02 (2006.01) ,A61K 9/19 (2006.01) ,A61K 31/00 (2006.01) ,C07C 323/25 (2006.01)
C CHEMISTRY; METALLURGY
07
ORGANIC CHEMISTRY
C
ACYCLIC OR CARBOCYCLIC COMPOUNDS
319
Preparation of thiols, sulfides, hydropolysulfides or polysulfides
02
of thiols
A HUMAN NECESSITIES
61
MEDICAL OR VETERINARY SCIENCE; HYGIENE
K
PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
9
Medicinal preparations characterised by special physical form
14
Particulate form, e.g. powders
19
lyophilised
A HUMAN NECESSITIES
61
MEDICAL OR VETERINARY SCIENCE; HYGIENE
K
PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
31
Medicinal preparations containing organic active ingredients
C CHEMISTRY; METALLURGY
07
ORGANIC CHEMISTRY
C
ACYCLIC OR CARBOCYCLIC COMPOUNDS
323
Thiols, sulfides, hydropolysulfides or polysulfides substituted by halogen, oxygen or nitrogen atoms, or by sulfur atoms not being part of thio groups
23
containing thio groups and nitrogen atoms, not being part of nitro or nitroso groups, bound to the same carbon skeleton
24
having the sulfur atoms of the thio groups bound to acyclic carbon atoms of the carbon skeleton
25
the carbon skeleton being acyclic and saturated
Applicants:
CLEVEXEL PHARMA [FR/FR]; 19 Avenue d'Italie 75013 Paris, FR
INSTITUT GUSTAVE ROUSSY [FR/FR]; 39, Rue Camille Desmoulins 94800 VILLEJUIF, FR
Inventors:
WANG-ZHANG, Xiuping; FR
PIVETTE, Perrine; FR
GONZALEZ, Karine; FR
DEUTSCH, Eric; FR
CLEMENSON, Céline; FR
Agent:
BLOT, Philippe; FR
NEYRET, Daniel; FR
DOMENEGO, Bertrand; FR
HABASQUE, Etienne; FR
COLOMBIE, Damien; FR
HOLTZ, Béatrice; FR
Priority Data:
16306582.430.11.2016EP
Title (EN) PROCESS FOR THE PREPARATION OF FREEZE-DRIED 2-[(3-AMINOPROPYL)AMINO]ETHANETHIOL FORMULATION
(FR) PROCÉDÉ DE PRÉPARATION D'UNE FORMULATION LYOPHILISÉE DE 2-[(3-AMINOPROPYL)AMINO]ÉTHANETHIOL
Abstract:
(EN) The present invention relates to a process for the preparation of freeze-dried 2-[(3-aminopropyl)amino]ethanethiol comprising the following steps: a) the reaction of a solution of amifostine with a strong acid, to obtain a solution of 2-[(3-aminopropyl)amino]ethanethiol, and b) the freeze-drying of the solution of 2-[(3-aminopropyl)amino]ethanethiol, with or without addition of excipients.
(FR) La présente invention concerne un procédé de préparation de 2-[(3-aminopropyl) amino]éthanethiol lyophilisé comprenant les étapes suivantes : a) réaction d'une solution d'amifostine avec un acide fort, pour obtenir une solution de 2-[(3-aminopropyl)amino]éthanethiol, et b) lyophilisation de la solution de 2-[(3-aminopropyl)amino]éthanethiol, avec ou sans addition d'excipients.
Designated States: AE, AG, AL, AM, AO, AT, AU, AZ, BA, BB, BG, BH, BN, BR, BW, BY, BZ, CA, CH, CL, CN, CO, CR, CU, CZ, DE, DJ, DK, DM, DO, DZ, EC, EE, EG, ES, FI, GB, GD, GE, GH, GM, GT, HN, HR, HU, ID, IL, IN, IR, IS, JO, JP, KE, KG, KH, KN, KP, KR, KW, KZ, LA, LC, LK, LR, LS, LU, LY, MA, MD, ME, MG, MK, MN, MW, MX, MY, MZ, NA, NG, NI, NO, NZ, OM, PA, PE, PG, PH, PL, PT, QA, RO, RS, RU, RW, SA, SC, SD, SE, SG, SK, SL, SM, ST, SV, SY, TH, TJ, TM, TN, TR, TT, TZ, UA, UG, US, UZ, VC, VN, ZA, ZM, ZW
African Regional Intellectual Property Organization (ARIPO) (BW, GH, GM, KE, LR, LS, MW, MZ, NA, RW, SD, SL, ST, SZ, TZ, UG, ZM, ZW)
Eurasian Patent Office (AM, AZ, BY, KG, KZ, RU, TJ, TM)
European Patent Office (EPO) (AL, AT, BE, BG, CH, CY, CZ, DE, DK, EE, ES, FI, FR, GB, GR, HR, HU, IE, IS, IT, LT, LU, LV, MC, MK, MT, NL, NO, PL, PT, RO, RS, SE, SI, SK, SM, TR)
African Intellectual Property Organization (BF, BJ, CF, CG, CI, CM, GA, GN, GQ, GW, KM, ML, MR, NE, SN, TD, TG)
Publication Language: English (EN)
Filing Language: English (EN)