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1. (WO2018099988) NK-MEDIATED IMMUNOTHERAPY AND USES THEREOF

Pub. No.:    WO/2018/099988    International Application No.:    PCT/EP2017/080848
Publication Date: Fri Jun 08 01:59:59 CEST 2018 International Filing Date: Thu Nov 30 00:59:59 CET 2017
IPC: C12N 5/0783
Applicants: FONDAZIONE RI.MED
ISTITUTO MEDITERRANEO PER I TRAPIANTI E TERAPIE AD ALTA SPECIALIZZAZIONE . ISMETT
Inventors: BADAMI, Ester
Title: NK-MEDIATED IMMUNOTHERAPY AND USES THEREOF
Abstract:
The present invention refers to a method for the production of activated CD3-CD56+ NK cells, activated CD3-CD56 NK+ cells obtainable with said method, their use, in particular for the treatment of a tumor, preferably a hepatocellular carcinoma (HCC), for use in the treatment and/or prevention of an HCV infection, for use in the treatment and/or prevention of a post-liver transplant HCV reinfection, or for use for prevention of a post-liver transplant HCC recurrence. The invention also concerns pharmaceutical compositions including said activated CD3 -CD56+ NK cells.