Search International and National Patent Collections

1. (WO2018099972) MONOCLONAL ANTIBODIES SPECIFIC FOR SEROGROUP W OF N. MENINGITIDIS AND USES THEREOF IN DIAGNOSIS

Pub. No.:    WO/2018/099972    International Application No.:    PCT/EP2017/080825
Publication Date: Fri Jun 08 01:59:59 CEST 2018 International Filing Date: Thu Nov 30 00:59:59 CET 2017
IPC: C07K 16/12
C07K 14/22
G01N 33/543
Applicants: INSTITUT PASTEUR
CENTRE NATIONAL DE LA RECHERCHE SCIENTIFIQUE
Inventors: TRAINCARD, François
TAHA, Muhamed-Kheir
TERRADE, Aude
DARTEVELLE, Sylvie
Title: MONOCLONAL ANTIBODIES SPECIFIC FOR SEROGROUP W OF N. MENINGITIDIS AND USES THEREOF IN DIAGNOSIS
Abstract:
The present invention is directed to monoclonal antibodies and antigen-binding portions thereof, specific for the capsular polysaccharides of Neisseria meningitidis serogroup W (NmW), wherein said antibodies or portions thereof are characterized by the sequences of the 6 CDR of the variable regions of the heavy chain (SEQ ID NO.: 4 or 5, 6 and 7) and light chain (SEQ ID NO.: 1, 2, 3). These antibodies are suitable for in vitro detection of Neisseria meningitidis serogroup W especially in a biological sample and by immunochromatography. The invention also concerns said monoclonal antibodies or adequate portions thereof in different diagnostic devices and methods, in order to detect NmW. The invention discloses also a rapid diagnostic test for detecting NmW in a biological fluid.