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1. (WO2018099946) NOVEL BICYCLIC NUCLEOSIDES AND OLIGOMERS PREPARED THEREFROM
Latest bibliographic data on file with the International Bureau    Submit observation

Pub. No.: WO/2018/099946 International Application No.: PCT/EP2017/080769
Publication Date: 07.06.2018 International Filing Date: 29.11.2017
IPC:
C07H 19/06 (2006.01) ,C07D 405/04 (2006.01) ,C07H 19/16 (2006.01) ,C07H 21/00 (2006.01) ,C07H 21/02 (2006.01) ,C07H 21/04 (2006.01) ,A61K 31/712 (2006.01) ,A61K 31/7125 (2006.01) ,A61K 31/7072 (2006.01) ,A61K 31/708 (2006.01) ,A61K 31/7076 (2006.01) ,A61K 31/7068 (2006.01) ,A61P 21/00 (2006.01)
Applicants: UNIVERSITÄT BERN[CH/CH]; Verwaltungsdirektion Hochschulstrasse 4 3012 Bern, CH
Inventors: LEUMANN, Christian; CH
EVÉQUOZ, Damien; CH
Agent: SPERRLE, Martin; CH
Priority Data:
16201350.230.11.2016EP
Title (EN) NOVEL BICYCLIC NUCLEOSIDES AND OLIGOMERS PREPARED THEREFROM
(FR) NOUVEAUX NUCLÉOSIDES BICYCLIQUES ET OLIGOMÈRES PRÉPARÉS À PARTIR DE CEUX-CI
Abstract: front page image
(EN) The present invention relates to novel bicyclic nucleosides and oligomers prepared therefrom. In particular, the present invention relates to a compound of formula (I), wherein one of T1 and T2 is OR1 or OR2; and the other of T1 and T2 is OR1 or OR2; wherein R1 is H or a hydroxyl protecting group, and R2 is a phosphorus moiety; and wherein Bx is a nucleobase. Furthermore, the present invention relates to said compounds, bicyclic nucleosides and said oligomers for use as a medicament in the prevention, treatment or diagnosis of a disease.
(FR) La présente invention concerne de nouveaux nucléosides bicycliques et des oligomères préparés à partir de ceux-ci. En particulier, la présente invention concerne un composé de formule (I), l'un de T1 et T2 étant OR1 ou OR2 ; et l'autre de T1 et T2 est OR1 ou OR2 ; dans laquelle R1 représente H ou un groupe de protection hydroxyle, et R2 représente une fraction de phosphore ; et Bx étant une nucléobase. En outre, la présente invention concerne lesdits composés, nucléosides bicycliques et lesdits oligomères destinés à être utilisés en tant que médicament dans la prévention, le traitement ou le diagnostic d'une maladie.
Designated States: AE, AG, AL, AM, AO, AT, AU, AZ, BA, BB, BG, BH, BN, BR, BW, BY, BZ, CA, CH, CL, CN, CO, CR, CU, CZ, DE, DJ, DK, DM, DO, DZ, EC, EE, EG, ES, FI, GB, GD, GE, GH, GM, GT, HN, HR, HU, ID, IL, IN, IR, IS, JO, JP, KE, KG, KH, KN, KP, KR, KW, KZ, LA, LC, LK, LR, LS, LU, LY, MA, MD, ME, MG, MK, MN, MW, MX, MY, MZ, NA, NG, NI, NO, NZ, OM, PA, PE, PG, PH, PL, PT, QA, RO, RS, RU, RW, SA, SC, SD, SE, SG, SK, SL, SM, ST, SV, SY, TH, TJ, TM, TN, TR, TT, TZ, UA, UG, US, UZ, VC, VN, ZA, ZM, ZW
African Regional Intellectual Property Organization (ARIPO) (BW, GH, GM, KE, LR, LS, MW, MZ, NA, RW, SD, SL, ST, SZ, TZ, UG, ZM, ZW)
Eurasian Patent Office (AM, AZ, BY, KG, KZ, RU, TJ, TM)
European Patent Office (EPO) (AL, AT, BE, BG, CH, CY, CZ, DE, DK, EE, ES, FI, FR, GB, GR, HR, HU, IE, IS, IT, LT, LU, LV, MC, MK, MT, NL, NO, PL, PT, RO, RS, SE, SI, SK, SM, TR)
African Intellectual Property Organization (BF, BJ, CF, CG, CI, CM, GA, GN, GQ, GW, KM, ML, MR, NE, SN, TD, TG)
Publication Language: English (EN)
Filing Language: English (EN)