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1. (WO2018099803) THE POTENTIAL OF CRBN-INDEPENDENT IMID RESENSITIZATION BY EPIGENETIC THERAPY
Latest bibliographic data on file with the International Bureau    Submit observation

Pub. No.:    WO/2018/099803    International Application No.:    PCT/EP2017/080237
Publication Date: 07.06.2018 International Filing Date: 23.11.2017
IPC:
A61K 31/7068 (2006.01), A61K 31/5355 (2006.01), A61K 45/06 (2006.01), A61P 35/00 (2006.01)
Applicants: UNIVERSITY OF COPENHAGEN [DK/DK]; Nørregade 10 1165 Copenhagen K (DK).
RIGSHOSPITALET [DK/DK]; Blegdamsvej 9 2100 Copenhagen (DK)
Inventors: DIMOPOULOS, Konstantinos; (DK).
GRØNBÆK, Kirsten; (DK)
Agent: AERA A/S; Gl. Kongevej 60, 18th floor 1850 Fredefiksberg C (DK)
Priority Data:
16202005.1 02.12.2016 EP
Title (EN) THE POTENTIAL OF CRBN-INDEPENDENT IMID RESENSITIZATION BY EPIGENETIC THERAPY
(FR) POTENTIEL DE RESENSIBILISATION À L'IMID INDÉPENDANTE DU CRBN PAR THÉRAPIE ÉPIGÉNÉTIQUE
Abstract: front page image
(EN)The present invention relates to an epigenetic treatment with a combination of 5-Aza and EPZ-6438 for reversing chromatin accessibility and re-establishment of IMiD sensitivity in cancers such at but not limited to Multiple Myeloma.
(FR)La présente invention concerne un traitement épigénétique avec une combinaison de 5-Aza et d'EPZ-6438 pour inverser l'accessibilité de la chromatine et le rétablissement de la sensibilité à l'IMiD dans des cancers tels que, entre autres, le myélome multiple.
Designated States: AE, AG, AL, AM, AO, AT, AU, AZ, BA, BB, BG, BH, BN, BR, BW, BY, BZ, CA, CH, CL, CN, CO, CR, CU, CZ, DE, DJ, DK, DM, DO, DZ, EC, EE, EG, ES, FI, GB, GD, GE, GH, GM, GT, HN, HR, HU, ID, IL, IN, IR, IS, JO, JP, KE, KG, KH, KN, KP, KR, KW, KZ, LA, LC, LK, LR, LS, LU, LY, MA, MD, ME, MG, MK, MN, MW, MX, MY, MZ, NA, NG, NI, NO, NZ, OM, PA, PE, PG, PH, PL, PT, QA, RO, RS, RU, RW, SA, SC, SD, SE, SG, SK, SL, SM, ST, SV, SY, TH, TJ, TM, TN, TR, TT, TZ, UA, UG, US, UZ, VC, VN, ZA, ZM, ZW.
African Regional Intellectual Property Organization (BW, GH, GM, KE, LR, LS, MW, MZ, NA, RW, SD, SL, ST, SZ, TZ, UG, ZM, ZW)
Eurasian Patent Organization (AM, AZ, BY, KG, KZ, RU, TJ, TM)
European Patent Office (AL, AT, BE, BG, CH, CY, CZ, DE, DK, EE, ES, FI, FR, GB, GR, HR, HU, IE, IS, IT, LT, LU, LV, MC, MK, MT, NL, NO, PL, PT, RO, RS, SE, SI, SK, SM, TR)
African Intellectual Property Organization (BF, BJ, CF, CG, CI, CM, GA, GN, GQ, GW, KM, ML, MR, NE, SN, TD, TG).
Publication Language: English (EN)
Filing Language: English (EN)