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1. (WO2018099803) THE POTENTIAL OF CRBN-INDEPENDENT IMID RESENSITIZATION BY EPIGENETIC THERAPY
Latest bibliographic data on file with the International Bureau    Submit observation

Pub. No.: WO/2018/099803 International Application No.: PCT/EP2017/080237
Publication Date: 07.06.2018 International Filing Date: 23.11.2017
Chapter 2 Demand Filed: 27.09.2018
IPC:
A61K 31/7068 (2006.01) ,A61K 31/5355 (2006.01) ,A61K 45/06 (2006.01) ,A61P 35/00 (2006.01)
A HUMAN NECESSITIES
61
MEDICAL OR VETERINARY SCIENCE; HYGIENE
K
PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
31
Medicinal preparations containing organic active ingredients
70
Carbohydrates; Sugars; Derivatives thereof
7042
Compounds having saccharide radicals and heterocyclic rings
7052
having nitrogen as a ring hetero atom, e.g. nucleosides, nucleotides
706
containing six-membered rings with nitrogen as a ring hetero atom
7064
containing condensed or non-condensed pyrimidines
7068
having oxo groups directly attached to the pyrimidine ring, e.g. cytidine, cytidylic acid
A HUMAN NECESSITIES
61
MEDICAL OR VETERINARY SCIENCE; HYGIENE
K
PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
31
Medicinal preparations containing organic active ingredients
33
Heterocyclic compounds
395
having nitrogen as a ring hetero atom, e.g. guanethidine, rifamycins
535
having six-membered rings with at least one nitrogen and at least one oxygen as the ring hetero atoms, e.g. 1,2-oxazines
5355
Non-condensed oxazines containing further heterocyclic rings
A HUMAN NECESSITIES
61
MEDICAL OR VETERINARY SCIENCE; HYGIENE
K
PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
45
Medicinal preparations containing active ingredients not provided for in groups A61K31/-A61K41/132
06
Mixtures of active ingredients without chemical characterisation, e.g. antiphlogistics and cardiaca
A HUMAN NECESSITIES
61
MEDICAL OR VETERINARY SCIENCE; HYGIENE
P
SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
35
Antineoplastic agents
Applicants: UNIVERSITY OF COPENHAGEN[DK/DK]; Nørregade 10 1165 Copenhagen K, DK
RIGSHOSPITALET[DK/DK]; Blegdamsvej 9 2100 Copenhagen Ø, DK
Inventors: DIMOPOULOS, Konstantinos; DK
GRØNBÆK, Kirsten; DK
Agent: AERA A/S; Gl. Kongevej 60, 18th floor 1850 Frederiksberg C, DK
Priority Data:
16202005.102.12.2016EP
Title (EN) THE POTENTIAL OF CRBN-INDEPENDENT IMID RESENSITIZATION BY EPIGENETIC THERAPY
(FR) POTENTIEL DE RESENSIBILISATION À L'IMID INDÉPENDANTE DU CRBN PAR THÉRAPIE ÉPIGÉNÉTIQUE
Abstract:
(EN) The present invention relates to an epigenetic treatment with a combination of 5-Aza and EPZ-6438 for reversing chromatin accessibility and re-establishment of IMiD sensitivity in cancers such at but not limited to Multiple Myeloma.
(FR) La présente invention concerne un traitement épigénétique avec une combinaison de 5-Aza et d'EPZ-6438 pour inverser l'accessibilité de la chromatine et le rétablissement de la sensibilité à l'IMiD dans des cancers tels que, entre autres, le myélome multiple.
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Designated States: AE, AG, AL, AM, AO, AT, AU, AZ, BA, BB, BG, BH, BN, BR, BW, BY, BZ, CA, CH, CL, CN, CO, CR, CU, CZ, DE, DJ, DK, DM, DO, DZ, EC, EE, EG, ES, FI, GB, GD, GE, GH, GM, GT, HN, HR, HU, ID, IL, IN, IR, IS, JO, JP, KE, KG, KH, KN, KP, KR, KW, KZ, LA, LC, LK, LR, LS, LU, LY, MA, MD, ME, MG, MK, MN, MW, MX, MY, MZ, NA, NG, NI, NO, NZ, OM, PA, PE, PG, PH, PL, PT, QA, RO, RS, RU, RW, SA, SC, SD, SE, SG, SK, SL, SM, ST, SV, SY, TH, TJ, TM, TN, TR, TT, TZ, UA, UG, US, UZ, VC, VN, ZA, ZM, ZW
African Regional Intellectual Property Organization (ARIPO) (BW, GH, GM, KE, LR, LS, MW, MZ, NA, RW, SD, SL, ST, SZ, TZ, UG, ZM, ZW)
Eurasian Patent Office (AM, AZ, BY, KG, KZ, RU, TJ, TM)
European Patent Office (EPO) (AL, AT, BE, BG, CH, CY, CZ, DE, DK, EE, ES, FI, FR, GB, GR, HR, HU, IE, IS, IT, LT, LU, LV, MC, MK, MT, NL, NO, PL, PT, RO, RS, SE, SI, SK, SM, TR)
African Intellectual Property Organization (BF, BJ, CF, CG, CI, CM, GA, GN, GQ, GW, KM, ML, MR, NE, SN, TD, TG)
Publication Language: English (EN)
Filing Language: English (EN)