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1. (WO2018099775) METHOD FOR ONLINE SAMPLING AN ALIQUOT FROM A MOBILE PHASE COMPRISING AN ANALYTE OF AN APPARATUS FOR PRODUCING A PHARMACEUTICAL OF CHEMICAL PRODUCT

Pub. No.:    WO/2018/099775    International Application No.:    PCT/EP2017/079998
Publication Date: Fri Jun 08 01:59:59 CEST 2018 International Filing Date: Thu Nov 23 00:59:59 CET 2017
IPC: G01N 1/14
B01L 3/02
G01N 35/10
Applicants: F. HOFFMANN-LA ROCHE AG
HOFFMANN-LA ROCHE INC.
Inventors: SCHEIDECKER, Benedikt
BRAAZ, Reinhard
VINNEMEIER, Josef
LASZKIEWICZ, Agathe Justine
Title: METHOD FOR ONLINE SAMPLING AN ALIQUOT FROM A MOBILE PHASE COMPRISING AN ANALYTE OF AN APPARATUS FOR PRODUCING A PHARMACEUTICAL OF CHEMICAL PRODUCT
Abstract:
A method for online sampling an aliquot from a mobile phase comprising an analyte of an apparatus (102) for producing a pharmaceutical or chemical product, wherein the apparatus (102) comprises an analytical device (114) and a tube (112), wherein the tube (112) comprises an inlet (116), an outlet (1 18) and at least one curved portion (120), wherein the outlet (118) is in fluid communication with the analytical device (114), wherein the curved portion (120) is located between the inlet (116) and the outlet (118), wherein a flow direction of the mobile phase is defined from the inlet (116) to the outlet (118), the method comprising: providing a sample device (124) comprising a needle (134) with a needle tip (136), a septum (138) pierceable by the needle (134) and a pump (128), wherein the needle (134) is moveable between an extended position in which the septum (138) is pierced by the needle (134), and a retracted position, in which the septum (138) is not pierced, disposing the sample device (124) at the curved portion (120) of the tube (112), moving the needle (134) to the extended position such that the needle tip (136) faces the flow direction, and operating the pump (128) so as to draw an aliquot out of the mobile phase. Further, a system (100) comprising an apparatus (102) for producing a pharmaceutical or chemical product and a sample device (124) is disclosed.