Search International and National Patent Collections

1. (WO2018099680) CITRATE SALTS OF A JANUS KINASE (JAK) INHIBITOR

Pub. No.:    WO/2018/099680    International Application No.:    PCT/EP2017/078044
Publication Date: Fri Jun 08 01:59:59 CEST 2018 International Filing Date: Fri Nov 03 00:59:59 CET 2017
IPC: C07D 487/04
A61K 31/519
A61P 19/02
Applicants: SANDOZ AG
Inventors: ADAMER, Verena
SCHREINER, Erwin, Paul
Title: CITRATE SALTS OF A JANUS KINASE (JAK) INHIBITOR
Abstract:
The present invention relates to citrate salts of baricitinib, in particular to baricitinib mono- and dicitrate, as well as to crystalline and amorphous forms thereof, and to methods for their preparation. Furthermore, the invention relates to a pharmaceutical composition comprising an effective and/or predetermined amount of one or more citrate salts of baricitinib and to the use of said pharmaceutical composition as a medicament, in particular for the treatment of rheumatoid arthritis.