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1. (WO2018099539) COMBINATION OF T-CELL REDIRECTING MULTIFUNCTIONAL ANTIBODIES WITH IMMUNE CHECKPOINT MODULATORS AND USES THEREOF
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Pub. No.: WO/2018/099539 International Application No.: PCT/EP2016/079128
Publication Date: 07.06.2018 International Filing Date: 29.11.2016
IPC:
A61K 39/39 (2006.01) ,C07K 16/28 (2006.01) ,C07K 16/30 (2006.01)
A HUMAN NECESSITIES
61
MEDICAL OR VETERINARY SCIENCE; HYGIENE
K
PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
39
Medicinal preparations containing antigens or antibodies
39
characterised by the immunostimulating additives, e.g. chemical adjuvants
C CHEMISTRY; METALLURGY
07
ORGANIC CHEMISTRY
K
PEPTIDES
16
Immunoglobulins, e.g. monoclonal or polyclonal antibodies
18
against material from animals or humans
28
against receptors, cell surface antigens or cell surface determinants
C CHEMISTRY; METALLURGY
07
ORGANIC CHEMISTRY
K
PEPTIDES
16
Immunoglobulins, e.g. monoclonal or polyclonal antibodies
18
against material from animals or humans
28
against receptors, cell surface antigens or cell surface determinants
30
from tumour cells
Applicants:
LINDHOFER, Horst [DE/DE]; DE
Inventors:
LINDHOFER, Horst; DE
RUF, Peter; DE
Agent:
VON STOSCH, Andreas; DE
EICHELBAUM, Kornelia; DE
LEHMBACHER, Michael; DE
BERGER, Michael; DE
HAHNER, Nadja; DE
Priority Data:
Title (EN) COMBINATION OF T-CELL REDIRECTING MULTIFUNCTIONAL ANTIBODIES WITH IMMUNE CHECKPOINT MODULATORS AND USES THEREOF
(FR) COMBINAISON D’ANTICORPS MULTIFONCTIONNELS DE REDIRECTION DE LYMPHOCYTES (T) AVEC DES MODULATEURS DE POINT DE CONTRÔLE IMMUNITAIRES ET LEURS UTILISATIONS
Abstract:
(EN) The present invention provides a combination of (i) an immune checkpoint modulator and (ii) a T-cell redirecting multifunctional antibody, or an antigen binding fragment thereof, for use in therapeutic treatment of a cancer disease. The T-cell redirecting multifunctional antibody comprises (a) a specificity against a T cell surface antigen; (b) a specificity against a cancer- and/or tumor-associated antigen; and (c) a binding site for human FcyRI, FcyRlla and/or FcyRlli, wherein the antibody, or the antigen binding fragment thereof, binds with a higher affinity to human FcyRI, FcyRlla and/or FcyRlli than to human FcyRllb.
(FR) La présente invention concerne une combinaison (i) d’un modulateur de point de contrôle immunitaire et (ii) d’un anticorps multifonctionnel de redirection des lymphocytes (T), ou son fragment de liaison à l’antigène, pour l’utilisation dans le traitement thérapeutique d’une maladie cancéreuse. L’anticorps multifonctionnel de redirection des lymphocytes (T) comprend (a) une spécificité vis-à-vis d'un antigène de surface de lymphocytes (T) ; (b) une spécificité vis-à-vis d'un antigène associé à un cancer et/ou une tumeur ; et (c) un site de liaison pour FcyRI, FcyRlla et/ou FcyRlli humains, l’anticorps, ou son fragment de liaison à l’antigène, se liant avec une affinité supérieure à FcyRI, FcyRlla et/ou FcyRlli humains par rapport à FcyRllb humain.
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Designated States: AE, AG, AL, AM, AO, AT, AU, AZ, BA, BB, BG, BH, BN, BR, BW, BY, BZ, CA, CH, CL, CN, CO, CR, CU, CZ, DE, DJ, DK, DM, DO, DZ, EC, EE, EG, ES, FI, GB, GD, GE, GH, GM, GT, HN, HR, HU, ID, IL, IN, IR, IS, JP, KE, KG, KN, KP, KR, KW, KZ, LA, LC, LK, LR, LS, LU, LY, MA, MD, ME, MG, MK, MN, MW, MX, MY, MZ, NA, NG, NI, NO, NZ, OM, PA, PE, PG, PH, PL, PT, QA, RO, RS, RU, RW, SA, SC, SD, SE, SG, SK, SL, SM, ST, SV, SY, TH, TJ, TM, TN, TR, TT, TZ, UA, UG, US, UZ, VC, VN, ZA, ZM, ZW
African Regional Intellectual Property Organization (ARIPO) (BW, GH, GM, KE, LR, LS, MW, MZ, NA, RW, SD, SL, ST, SZ, TZ, UG, ZM, ZW)
Eurasian Patent Office (AM, AZ, BY, KG, KZ, RU, TJ, TM)
European Patent Office (EPO) (AL, AT, BE, BG, CH, CY, CZ, DE, DK, EE, ES, FI, FR, GB, GR, HR, HU, IE, IS, IT, LT, LU, LV, MC, MK, MT, NL, NO, PL, PT, RO, RS, SE, SI, SK, SM, TR)
African Intellectual Property Organization (BF, BJ, CF, CG, CI, CM, GA, GN, GQ, GW, KM, ML, MR, NE, SN, TD, TG)
Publication Language: English (EN)
Filing Language: English (EN)