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1. (WO2018099148) USE OF MICROCYSTINS IN PREPARATION OF DRUGS FOR PREVENTING OR TREATING ORGAN AND TISSUE FIBROSIS DISEASES
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Pub. No.: WO/2018/099148 International Application No.: PCT/CN2017/099249
Publication Date: 07.06.2018 International Filing Date: 28.08.2017
IPC:
A61K 38/12 (2006.01) ,A61P 11/00 (2006.01)
A HUMAN NECESSITIES
61
MEDICAL OR VETERINARY SCIENCE; HYGIENE
K
PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
38
Medicinal preparations containing peptides
04
Peptides having up to 20 amino acids in a fully defined sequence; Derivatives thereof
12
Cyclic peptides
A HUMAN NECESSITIES
61
MEDICAL OR VETERINARY SCIENCE; HYGIENE
P
SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
11
Drugs for disorders of the respiratory system
Applicants: NANJING UNIVERSITY[CN/CN]; No. 22 Hankou Road Nanjing, Jiangsu 210093, CN
Inventors: WANG, Yaping; CN
XU, Lizhi; CN
WANG, Jie; CN
ZHAO, Qingya; CN
Agent: BEI&OCEAN; Bld.A Ste 603, Time Plaza West An-Shan Road, Nankai District Tianjin 300193, CN
Priority Data:
201611079521.630.11.2016CN
201710014483.409.01.2017CN
Title (EN) USE OF MICROCYSTINS IN PREPARATION OF DRUGS FOR PREVENTING OR TREATING ORGAN AND TISSUE FIBROSIS DISEASES
(FR) UTILISATION DE MICROCYSTINES DANS LA PRÉPARATION DE MÉDICAMENTS POUR LA PRÉVENTION OU LE TRAITEMENT DE MALADIES DE FIBROSE D'ORGANE ET DE TISSU
(ZH) 微囊藻毒素在制备用于预防或治疗器官组织纤维化疾病的药物中的用途
Abstract:
(EN) Use of microcystins having a monocyclic heptapeptide structure in preparation of drugs for preventing or treating organ and tissue fibrosis diseases. Preferably, the microcystins are microcystins-LR with amino acids at positions 2 and 4 of a monocyclic heptapeptide structure thereof being leucine and arginine respectively, or are microcystins-RR with amino acids at positions 2 and 4 thereof being both arginine. Also provided is a method for inhibiting myofibroblast differentiation and collagen synthesis. The method is implemented by inhibiting a TGF-β/Smad signal pathway by using one or more microcystins.
(FR) L'invention concerne l'utilisation de microcystines ayant une structure heptapeptide monocyclique dans la préparation de médicaments pour la prévention ou le traitement de maladies de fibrose d'organe et de tissu. De préférence, les microcystines sont des microcystines-LR avec des acides aminés aux positions 2 et 4 d'une structure heptapeptide monocyclique de celles-ci étant la leucine et l'arginine respectivement, ou sont des microcystines-RR avec des acides aminés aux positions 2 et 4 de celles-ci étant à la fois l'arginine. L'invention concerne également un procédé d'inhibition de la différenciation myofibroblastique et de la synthèse du collagène. Le procédé est mis en œuvre par l'inhibition d'une voie de signalisation de TGF-bêta/Smad à l'aide d'une ou de plusieurs microcystines.
(ZH) 单环七肽结构微囊藻毒素在制备用于预防或治疗器官组织纤维化疾病的药物中的用途。优选地,所述微囊藻毒素是其单环七肽结构的第二和第四位氨基酸分别为亮氨酸和精氨酸的微囊藻毒素-LR,或者是其第二和第四位氨基酸均为精氨酸的微囊藻毒素-RR。还涉及一种抑制肌成纤维细胞分化和胶原蛋白合成的方法,该方法通过使用一种或多种微囊藻毒素阻抑TGF-β/Smad信号通路而实现。
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African Regional Intellectual Property Organization (ARIPO) (BW, GH, GM, KE, LR, LS, MW, MZ, NA, RW, SD, SL, ST, SZ, TZ, UG, ZM, ZW)
Eurasian Patent Office (AM, AZ, BY, KG, KZ, RU, TJ, TM)
European Patent Office (EPO) (AL, AT, BE, BG, CH, CY, CZ, DE, DK, EE, ES, FI, FR, GB, GR, HR, HU, IE, IS, IT, LT, LU, LV, MC, MK, MT, NL, NO, PL, PT, RO, RS, SE, SI, SK, SM, TR)
African Intellectual Property Organization (BF, BJ, CF, CG, CI, CM, GA, GN, GQ, GW, KM, ML, MR, NE, SN, TD, TG)
Publication Language: Chinese (ZH)
Filing Language: Chinese (ZH)