Some content of this application is unavailable at the moment.
If this situation persist, please contact us atFeedback&Contact
1. (WO2018098561) FUSED PYRIMIDINE COMPOUNDS AS BRD4 AND JAK2 DUAL INHIBITORS AND METHODS FOR USE THEREOF
Latest bibliographic data on file with the International Bureau    Submit observation

Pub. No.: WO/2018/098561 International Application No.: PCT/CA2017/000258
Publication Date: 07.06.2018 International Filing Date: 01.12.2017
IPC:
C07D 495/04 (2006.01) ,A61K 31/519 (2006.01) ,A61P 35/00 (2006.01) ,C07D 487/04 (2006.01)
C CHEMISTRY; METALLURGY
07
ORGANIC CHEMISTRY
D
HETEROCYCLIC COMPOUNDS
495
Heterocyclic compounds containing in the condensed system at least one hetero ring having sulfur atoms as the only ring hetero atoms
02
in which the condensed system contains two hetero rings
04
Ortho-condensed systems
A HUMAN NECESSITIES
61
MEDICAL OR VETERINARY SCIENCE; HYGIENE
K
PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
31
Medicinal preparations containing organic active ingredients
33
Heterocyclic compounds
395
having nitrogen as a ring hetero atom, e.g. guanethidine, rifamycins
495
having six-membered rings with two nitrogen atoms as the only ring hetero atoms, e.g. piperazine
505
Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim
519
ortho- or peri-condensed with heterocyclic rings
A HUMAN NECESSITIES
61
MEDICAL OR VETERINARY SCIENCE; HYGIENE
P
SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
35
Antineoplastic agents
C CHEMISTRY; METALLURGY
07
ORGANIC CHEMISTRY
D
HETEROCYCLIC COMPOUNDS
487
Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/-C07D477/183
02
in which the condensed system contains two hetero rings
04
Ortho-condensed systems
Applicants:
APTOSE BIOSCIENCES INC. [CA/CA]; 5955 Airport Road Suite 228 Mississauga, Ontario L4V 1R9, CA
Inventors:
UPADHAYAYA, Ram Shankar; IN
KETHIRI, Raghava; IN
MADAN, Sachin; IN
RAJAIAH, Santosh Kumar Kotturi; IN
Agent:
DEETH WILLIAMS WALLS LLP; 150 York Street Suite 400 Toronto, Ontario M5H 3S5, CA
Priority Data:
62/428,75601.12.2016US
Title (EN) FUSED PYRIMIDINE COMPOUNDS AS BRD4 AND JAK2 DUAL INHIBITORS AND METHODS FOR USE THEREOF
(FR) COMPOSÉS DE PYRIMIDINE FUSIONNÉS EN TANT QU'INHIBITEURS DOUBLES DE BRD4 ET DE JAK2 ET LEURS PROCÉDÉS D'UTILISATION
Abstract:
(EN) The present invention relates to fused pyrimidine compounds, particularly pyrrolopyrimidine and thienopyrimidine compounds and derivatives thereof, pharmaceutical compositions thereof, and methods of inhibiting BRD4 and/or JAK2, as well as methods of treating various diseases and conditions, such as cancer and leukemia, with such compounds. Bromodomain binding and JAK activity are included.
(FR) La présente invention concerne des composés de pyrimidine fusionnés, en particulier des composés de pyrrolopyrimidine et de thiénopyrimidine et des dérivés de ceux-ci, des compositions pharmaceutiques de ces composés, et des procédés d'inhibition de BRD4 et/ou de JAK2, ainsi que des procédés de traitement de diverses maladies et affections, telles que le cancer et la leucémie, avec de tels composés. L'invention concerne également une liaison de bromodomaine et une activité de JAK.
Designated States: AE, AG, AL, AM, AO, AT, AU, AZ, BA, BB, BG, BH, BN, BR, BW, BY, BZ, CA, CH, CL, CN, CO, CR, CU, CZ, DE, DJ, DK, DM, DO, DZ, EC, EE, EG, ES, FI, GB, GD, GE, GH, GM, GT, HN, HR, HU, ID, IL, IN, IR, IS, JO, JP, KE, KG, KH, KN, KP, KR, KW, KZ, LA, LC, LK, LR, LS, LU, LY, MA, MD, ME, MG, MK, MN, MW, MX, MY, MZ, NA, NG, NI, NO, NZ, OM, PA, PE, PG, PH, PL, PT, QA, RO, RS, RU, RW, SA, SC, SD, SE, SG, SK, SL, SM, ST, SV, SY, TH, TJ, TM, TN, TR, TT, TZ, UA, UG, US, UZ, VC, VN, ZA, ZM, ZW
African Regional Intellectual Property Organization (ARIPO) (BW, GH, GM, KE, LR, LS, MW, MZ, NA, RW, SD, SL, ST, SZ, TZ, UG, ZM, ZW)
Eurasian Patent Office (AM, AZ, BY, KG, KZ, RU, TJ, TM)
European Patent Office (EPO) (AL, AT, BE, BG, CH, CY, CZ, DE, DK, EE, ES, FI, FR, GB, GR, HR, HU, IE, IS, IT, LT, LU, LV, MC, MK, MT, NL, NO, PL, PT, RO, RS, SE, SI, SK, SM, TR)
African Intellectual Property Organization (BF, BJ, CF, CG, CI, CM, GA, GN, GQ, GW, KM, ML, MR, NE, SN, TD, TG)
Publication Language: English (EN)
Filing Language: English (EN)