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1. WO2018097307 - ANTIGEN-BINDING DOMAIN, AND POLYPEPTIDE INCLUDING CONVEYING SECTION

Publication Number WO/2018/097307
Publication Date 31.05.2018
International Application No. PCT/JP2017/042542
International Filing Date 28.11.2017
IPC
C12N 15/09 2006.1
CCHEMISTRY; METALLURGY
12BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
NMICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
15Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
09Recombinant DNA-technology
A61K 38/16 2006.1
AHUMAN NECESSITIES
61MEDICAL OR VETERINARY SCIENCE; HYGIENE
KPREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
38Medicinal preparations containing peptides
16Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
A61K 39/395 2006.1
AHUMAN NECESSITIES
61MEDICAL OR VETERINARY SCIENCE; HYGIENE
KPREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
39Medicinal preparations containing antigens or antibodies
395Antibodies; Immunoglobulins; Immune serum, e.g. antilymphocytic serum
A61K 47/64 2017.1
AHUMAN NECESSITIES
61MEDICAL OR VETERINARY SCIENCE; HYGIENE
KPREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
47Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
50the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates
51the non-active ingredient being a modifying agent
62the modifying agent being a protein, peptide or polyamino acid
64Drug-peptide, drug-protein or drug-polyamino acid conjugates, i.e. the modifying agent being a peptide, protein or polyamino acid which is covalently bonded or complexed to a therapeutically active agent
A61K 47/65 2017.1
AHUMAN NECESSITIES
61MEDICAL OR VETERINARY SCIENCE; HYGIENE
KPREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
47Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
50the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates
51the non-active ingredient being a modifying agent
62the modifying agent being a protein, peptide or polyamino acid
65Peptidic linkers, binders or spacers, e.g. peptidic enzyme-labile linkers
C07K 19/00 2006.1
CCHEMISTRY; METALLURGY
07ORGANIC CHEMISTRY
KPEPTIDES
19Hybrid peptides
CPC
A61K 2039/505
AHUMAN NECESSITIES
61MEDICAL OR VETERINARY SCIENCE; HYGIENE
KPREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
39Medicinal preparations containing antigens or antibodies
505comprising antibodies
A61K 38/00
AHUMAN NECESSITIES
61MEDICAL OR VETERINARY SCIENCE; HYGIENE
KPREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
38Medicinal preparations containing peptides
A61K 38/16
AHUMAN NECESSITIES
61MEDICAL OR VETERINARY SCIENCE; HYGIENE
KPREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
38Medicinal preparations containing peptides
16Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
A61K 47/64
AHUMAN NECESSITIES
61MEDICAL OR VETERINARY SCIENCE; HYGIENE
KPREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
47Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
50the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates
51the non-active ingredient being a modifying agent
62the modifying agent being a protein, peptide or polyamino acid
64Drug-peptide, drug-protein or drug-polyamino acid conjugates, i.e. the modifying agent being a peptide, protein or polyamino acid which is covalently bonded or complexed to a therapeutically active agent
A61K 47/65
AHUMAN NECESSITIES
61MEDICAL OR VETERINARY SCIENCE; HYGIENE
KPREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
47Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
50the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates
51the non-active ingredient being a modifying agent
62the modifying agent being a protein, peptide or polyamino acid
65Peptidic linkers, binders or spacers, e.g. peptidic enzyme-labile linkers
A61P 29/00
AHUMAN NECESSITIES
61MEDICAL OR VETERINARY SCIENCE; HYGIENE
PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
29Non-central analgesic, antipyretic or anti-inflammatory agents, e.g antirheumatic agents; Non-steroidal anti-inflammatory drugs (NSAIDs)
Applicants
  • 中外製薬株式会社 CHUGAI SEIYAKU KABUSHIKI KAISHA [JP]/[JP]
Inventors
  • 井川 智之 IGAWA, Tomoyuki
  • 石川 広幸 ISHIKAWA, Hiroyuki
  • 廣庭 奈緒香 HIRONIWA, Naoka
Agents
  • 春名 雅夫 HARUNA, Masao
  • 清水 初志 SHIMIZU, Hatsushi
  • 山口 裕孝 YAMAGUCHI, Hirotaka
  • 刑部 俊 OSAKABE, Suguru
  • 井上 隆一 INOUE, Ryuichi
  • 佐藤 利光 SATO, Toshimitsu
  • 新見 浩一 SHIMMI, Hirokazu
  • 小林 智彦 KOBAYASHI, Tomohiko
  • 小寺 秀紀 KODERA, Hideki
  • 大関 雅人 OHZEKI, Masato
  • 五十嵐 義弘 IGARASHI, Yoshihiro
  • 川本 和弥 KAWAMOTO, Kazuya
Priority Data
2016-22979428.11.2016JP
Publication Language Japanese (ja)
Filing Language Japanese (JA)
Designated States
Title
(EN) ANTIGEN-BINDING DOMAIN, AND POLYPEPTIDE INCLUDING CONVEYING SECTION
(FR) DOMAINE DE LIAISON À L'ANTIGÈNE ET POLYPEPTIDE COMPRENANT UNE SECTION DE TRANSPORT
(JA) 抗原結合ドメインおよび運搬部分を含むポリペプチド
Abstract
(EN) The present invention pertains to: a polypeptide that includes an antigen-binding domain and a conveying section having an inhibitory domain for inhibiting the antigen-binding activity of the antigen-binding domain, and that has a half-life longer than that of the antigen-binding domain when existing alone; a production method and screening method for the polypeptide; a pharmaceutical composition containing the polypeptide; a production method and screening method for a single-domain antibody the antigen-binding activity of which is inhibited by being associated with a specific VL/VH/VHH; and a library of fused polypeptides including a single-domain antibody the antigen-binding activity of which is inhibited by being associated with a specific VL/VH/VHH.
(FR) La présente invention se rapporte : à un polypeptide qui comprend un domaine de liaison à l'antigène et une section de transport ayant un domaine inhibiteur pour inhiber l'activité de liaison à l'antigène du domaine de liaison à l'antigène, et qui présente une demi-vie plus longue que celle du domaine de liaison à l'antigène lorsqu'il existe seul ; à un procédé de production et à un procédé de criblage pour le polypeptide ; à une composition pharmaceutique contenant le polypeptide ; à un procédé de production et à un procédé de criblage pour un anticorps à domaine unique dont l'activité de liaison à l'antigène est inhibée en étant associée à un VL/VH/VHH spécifique ; et à une bibliothèque de polypeptides fusionnés comprenant un anticorps à domaine unique dont l'activité de liaison à l'antigène est inhibée en étant associée à un VL/VH/VHH spécifique.
(JA) 本発明は、抗原結合ドメインと、抗原結合ドメインの抗原結合活性を抑制する抑制ドメインを有する運搬部分とを含み、かつ単独で存在する抗原結合ドメインより長い半減期を有するポリペプチド、当該ポリペプチドの製造方法およびスクリーニング方法、当該ポリペプチドを含む医薬組成物、特定のVL/VH/VHHと会合することで抗原結合活性が抑制される単ドメイン抗体の製造方法及びスクリーニング方法、ならびに特定のVL/VH/VHHと会合することで抗原結合活性が抑制される単ドメイン抗体を含む融合ポリペプチドのライブラリに関する。
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