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1. WO2018096504 - CBD PRODRUGS, COMPOSITIONS, AND METHODS OF ADMINISTERING CBD AND CBD PRODRUGS

Publication Number WO/2018/096504
Publication Date 31.05.2018
International Application No. PCT/IB2017/057403
International Filing Date 27.11.2017
IPC
C07F 9/38 2006.1
CCHEMISTRY; METALLURGY
07ORGANIC CHEMISTRY
FACYCLIC, CARBOCYCLIC, OR HETEROCYCLIC COMPOUNDS CONTAINING ELEMENTS OTHER THAN CARBON, HYDROGEN, HALOGEN, OXYGEN, NITROGEN, SULFUR, SELENIUM OR TELLURIUM
9Compounds containing elements of Groups 5 or 15 of the Periodic System
02Phosphorus compounds
28with one or more P-C bonds
38Phosphonic acids ; Thiophosphonic acids
C07C 279/14 2006.1
CCHEMISTRY; METALLURGY
07ORGANIC CHEMISTRY
CACYCLIC OR CARBOCYCLIC COMPOUNDS
279Derivatives of guanidine, i.e. compounds containing the group the singly-bound nitrogen atoms not being part of nitro or nitroso groups
04having nitrogen atoms of guanidine groups bound to acyclic carbon atoms of a carbon skeleton
14being further substituted by carboxyl groups
C07C 203/10 2006.1
CCHEMISTRY; METALLURGY
07ORGANIC CHEMISTRY
CACYCLIC OR CARBOCYCLIC COMPOUNDS
203Esters of nitric or nitrous acid
02Esters of nitric acid
10having nitrate groups bound to carbon atoms of six-membered aromatic rings
C07C 305/24 2006.1
CCHEMISTRY; METALLURGY
07ORGANIC CHEMISTRY
CACYCLIC OR CARBOCYCLIC COMPOUNDS
305Esters of sulfuric acids
22having oxygen atoms of sulfate groups bound to carbon atoms of six-membered aromatic rings
24of non-condensed six-membered aromatic rings
C07C 229/18 2006.1
CCHEMISTRY; METALLURGY
07ORGANIC CHEMISTRY
CACYCLIC OR CARBOCYCLIC COMPOUNDS
229Compounds containing amino and carboxyl groups bound to the same carbon skeleton
02having amino and carboxyl groups bound to acyclic carbon atoms of the same carbon skeleton
04the carbon skeleton being acyclic and saturated
06having only one amino and one carboxyl group bound to the carbon skeleton
18the nitrogen atom of the amino group being further bound to carbon atoms of six-membered aromatic rings
C07F 9/40 2006.1
CCHEMISTRY; METALLURGY
07ORGANIC CHEMISTRY
FACYCLIC, CARBOCYCLIC, OR HETEROCYCLIC COMPOUNDS CONTAINING ELEMENTS OTHER THAN CARBON, HYDROGEN, HALOGEN, OXYGEN, NITROGEN, SULFUR, SELENIUM OR TELLURIUM
9Compounds containing elements of Groups 5 or 15 of the Periodic System
02Phosphorus compounds
28with one or more P-C bonds
38Phosphonic acids ; Thiophosphonic acids
40Esters thereof
CPC
A61P 17/10
AHUMAN NECESSITIES
61MEDICAL OR VETERINARY SCIENCE; HYGIENE
PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
17Drugs for dermatological disorders
10Anti-acne agents
C07C 201/02
CCHEMISTRY; METALLURGY
07ORGANIC CHEMISTRY
CACYCLIC OR CARBOCYCLIC COMPOUNDS
201Preparation of esters of nitric or nitrous acid or of compounds containing nitro or nitroso groups bound to a carbon skeleton
02Preparation of esters of nitric acid
C07C 203/10
CCHEMISTRY; METALLURGY
07ORGANIC CHEMISTRY
CACYCLIC OR CARBOCYCLIC COMPOUNDS
203Esters of nitric or nitrous acid
02Esters of nitric acid
10having nitrate groups bound to carbon atoms of six-membered aromatic rings
C07C 227/20
CCHEMISTRY; METALLURGY
07ORGANIC CHEMISTRY
CACYCLIC OR CARBOCYCLIC COMPOUNDS
227Preparation of compounds containing amino and carboxyl groups bound to the same carbon skeleton
14from compounds containing already amino and carboxyl groups or derivatives thereof
18by reactions involving amino or carboxyl groups, e.g. hydrolysis of esters or amides, by formation of halides, salts or esters
20by hydrolysis of N-acylated amino-acids or derivatives thereof, e.g. hydrolysis of carbamates
C07C 2603/18
CCHEMISTRY; METALLURGY
07ORGANIC CHEMISTRY
CACYCLIC OR CARBOCYCLIC COMPOUNDS
2603Systems containing at least three condensed rings
02Ortho- or ortho- and peri-condensed systems
04containing three rings
06containing at least one ring with less than six ring members
10containing five-membered rings
12only one five-membered ring
18Fluorenes; Hydrogenated fluorenes
C07C 269/06
CCHEMISTRY; METALLURGY
07ORGANIC CHEMISTRY
CACYCLIC OR CARBOCYCLIC COMPOUNDS
269Preparation of derivatives of carbamic acid, i.e. compounds containing any of the groups , the nitrogen atom not being part of nitro or nitroso groups
06by reactions not involving the formation of carbamate groups
Applicants
  • KALYTERA THERAPEUTICS, INC [US]/[US]
Inventors
  • SALZMAN, Andrew
  • FLOWER, Kevin
  • GARNER, C. Edwin
  • JAGTAP, Parkash
  • MUSA, Saana
Priority Data
62/426,69628.11.2016US
Publication Language English (en)
Filing Language English (EN)
Designated States
Title
(EN) CBD PRODRUGS, COMPOSITIONS, AND METHODS OF ADMINISTERING CBD AND CBD PRODRUGS
(FR) PROMÉDICAMENTS CBD, COMPOSITIONS ET PROCÉDÉS D'ADMINISTRATION DE CBD ET DE PROMÉDICAMENTS CBD
Abstract
(EN) Compounds of Formula (I), including stereoisomers and salts thereof, and compositions, methods of treatment and prevention, and methods of preparing, the same: Formula (I) wherein X is O or a direct bond; wherein when X is O, R1 and R2 are each independently selected from -H, -SO3Na, -PO(ONa)2, -PO(OCH2CH3), -CH2PO(ONa)2, -NO2, -(L)-valine ester, -(L)-N-methyl arginine ester, -α-guanidinoglutaric acid ester, -2-iminobiotin ester, -3- hydroxy anthranilic acid ester, -(L)-nitroarginine ester, -(L)- N5-(1-iminoethyl)-(L)- ornithine (NIO) ester, -(L)-N,N dimethylarginine ester, -(L)- N6-(1-iminoethyl)-(L)-lysine (NIL) ester, -(L)- N-monomethyl-(L)-arginine (NMMA) ester, -N-amino-(L)-arginine ester, -N-propyl-(L)-arginine ester, -S-methyl-(L)-thiocitrulline ester, -methyl-(L)-NIO ester, - vinyl -(L)-NIO ester, and -propenyl-(L)-NK) ester; and wherein when X is a direct bond, R1 and R2 are Formula (II).
(FR) L'invention concerne des composés de formule (I), y compris des stéréoisomères et des sels de ceux-ci, des compositions, des procédés de traitement et de prévention, et des procédés de préparation de ceux-ci : formule (I) X étant O ou une liaison directe; lorsque X est O, R 1 et R 2 sont chacun indépendamment choisis parmi -H, -SO 3 Na, -PO (ONa) 2 , -PO (OCH 2 CH 3 ), -CH 2 PO (ONa) 2 , -NO 2 , - (L)-valine ester, ester - (L)-N-méthyl arginine, acide ester -alpha-guanidinoglutarique, ester -2-iminobiotine, acide ester -3-hydroxy anthranilique, ester - (L)-nitroarginine, ester - (L)-N5- (1-iminoéthyl)- (L)-ornithine (NIO), ester - (L)-N, N diméthylarginine, ester - (L)-N6- (1-iminoéthyle)- (L)-lysine (NIL), ester - (L)-N-monométhyl- (L)-arginine (NMMA)), ester -N-amino- (L)-arginine, ester -N-propyl- (L)-méthyl- (L)-thiocitrulline ester, -méthyl- (L)-NIO, ester -s-méthyl- (L)-thiocitrulline, ester -méthyl- (L)-NIO, ester -vinyl- (L)-NIO, et ester -propényl- (L)-NK); et lorsque X est une liaison directe, R 1 et R 2 sont la formule (II).
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