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1. (WO2018090054) METHODS FOR TREATING PARKINSON'S DISEASE
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Pub. No.: WO/2018/090054 International Application No.: PCT/US2017/061640
Publication Date: 17.05.2018 International Filing Date: 14.11.2017
IPC:
A61K 31/427 (2006.01) ,A61K 31/4409 (2006.01) ,A61P 25/16 (2006.01) ,A61P 25/18 (2006.01) ,C12Q 1/02 (2006.01)
[IPC code unknown for A61K 31/427][IPC code unknown for A61K 31/4409][IPC code unknown for A61P 25/16][IPC code unknown for A61P 25/18][IPC code unknown for C12Q 1/02]
Applicants:
BERG LLC [US/US]; 500 Old Connecticut Path, Building B Framingham, Massachusetts 01701, US
Inventors:
VISHNUDAS, Vivek K.; US
NARAIN, Paula Patricia; US
CHAUFTY, Jeremy; US
GESTA, Stephane; US
ROESSLER, Reinhard; US
NARAIN, Niven Rajin; US
SARANGARAJAN, Rangaprasad; US
Agent:
MELLO, Jill Ann; US
BELT, Erik, P.; US
BOWLES, Anita, M.; US
BAI, Mei; US
BROMBERG, Lee, C.; US
Priority Data:
62/421,94614.11.2016US
Title (EN) METHODS FOR TREATING PARKINSON'S DISEASE
(FR) MÉTHODE DE TRAITEMENT DE LA MALADIE DE PARKINSON
Abstract:
(EN) The present invention provides methods for treating Parkinson' s Disease (PD), e.g., PD associated with a genetic mutation in a glucocerebrosidase (GBA) gene or a leucine rich repeat kinase 2 (LRRK2) gene. The methods comprise administering to the subject a modulator, e.g., an inhibitor, of p53-inducible gene 3 (PIG3).
(FR) La présente invention concerne des méthodes de traitement de la maladie de Parkinson (MP), par exemple, la MP associée à une mutation génétique dans un gène de glucocérébrosidase (GBA) ou un gène 2 (LRRK2) de kinase de répétition riche en leucine (LRRK2). Les méthodes comprennent l'administration au sujet d'un modulateur, par exemple, d'un inhibiteur, du gène 3 inductible par p53 (PIG3).
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Designated States: AE, AG, AL, AM, AO, AT, AU, AZ, BA, BB, BG, BH, BN, BR, BW, BY, BZ, CA, CH, CL, CN, CO, CR, CU, CZ, DE, DJ, DK, DM, DO, DZ, EC, EE, EG, ES, FI, GB, GD, GE, GH, GM, GT, HN, HR, HU, ID, IL, IN, IR, IS, JO, JP, KE, KG, KH, KN, KP, KR, KW, KZ, LA, LC, LK, LR, LS, LU, LY, MA, MD, ME, MG, MK, MN, MW, MX, MY, MZ, NA, NG, NI, NO, NZ, OM, PA, PE, PG, PH, PL, PT, QA, RO, RS, RU, RW, SA, SC, SD, SE, SG, SK, SL, SM, ST, SV, SY, TH, TJ, TM, TN, TR, TT, TZ, UA, UG, US, UZ, VC, VN, ZA, ZM, ZW
African Regional Intellectual Property Organization (ARIPO) (BW, GH, GM, KE, LR, LS, MW, MZ, NA, RW, SD, SL, ST, SZ, TZ, UG, ZM, ZW)
Eurasian Patent Office (AM, AZ, BY, KG, KZ, RU, TJ, TM)
European Patent Office (EPO) (AL, AT, BE, BG, CH, CY, CZ, DE, DK, EE, ES, FI, FR, GB, GR, HR, HU, IE, IS, IT, LT, LU, LV, MC, MK, MT, NL, NO, PL, PT, RO, RS, SE, SI, SK, SM, TR)
African Intellectual Property Organization (BF, BJ, CF, CG, CI, CM, GA, GN, GQ, GW, KM, ML, MR, NE, SN, TD, TG)
Publication Language: English (EN)
Filing Language: English (EN)