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1. (WO2018090053) METHODS AND APPARATUS FOR A SHEAR-ENHANCED CNT-ASSEMBLY NANOSENSOR PLATFORM FOR ULTRA-SENSITIVE AND SELECTIVE PROTEIN DETECTION
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Pub. No.: WO/2018/090053 International Application No.: PCT/US2017/061638
Publication Date: 17.05.2018 International Filing Date: 14.11.2017
IPC:
C40B 60/12 (2006.01) ,G01N 33/49 (2006.01) ,G01N 27/327 (2006.01) ,C12Q 1/68 (2018.01)
C CHEMISTRY; METALLURGY
40
COMBINATORIAL TECHNOLOGY
B
COMBINATORIAL CHEMISTRY; LIBRARIES, e.g. CHEMICAL LIBRARIES, IN SILICO LIBRARIES
60
Apparatus specially adapted for use in combinatorial chemistry or with libraries
12
for screening libraries
G PHYSICS
01
MEASURING; TESTING
N
INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
33
Investigating or analysing materials by specific methods not covered by groups G01N1/-G01N31/131
48
Biological material, e.g. blood, urine; Haemocytometers
483
Physical analysis of biological material
487
of liquid biological material
49
blood
G PHYSICS
01
MEASURING; TESTING
N
INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
27
Investigating or analysing materials by the use of electric, electro-chemical, or magnetic means
26
by investigating electrochemical variables; by using electrolysis or electrophoresis
28
Electrolytic cell components
30
Electrodes, e.g. test electrodes; Half-cells
327
Biochemical electrodes
C CHEMISTRY; METALLURGY
12
BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
Q
MEASURING OR TESTING PROCESSES INVOLVING ENZYMES OR MICRO-ORGANISMS; COMPOSITIONS OR TEST PAPERS THEREFOR; PROCESSES OF PREPARING SUCH COMPOSITIONS; CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL OR ENZYMOLOGICAL PROCESSES
1
Measuring or testing processes involving enzymes or micro-organisms; Compositions therefor; Processes of preparing such compositions
68
involving nucleic acids
Applicants: UNIVERSITY OF NOTRE DAME DU LAC[US/US]; Innovation Park at Notre Dame 1400 East Angela Boulevard South Bend, Indiana 46617, US
Inventors: CHANG, Hsueh-Chia; US
LI, Diya; US
SENAPATI, Satyajyoti; US
Agent: JAROSIK, Keith R.; US
JAROSIK, Gary R.; US
MALLOY, Dennis P.; US
GIROUX, Jonathan E.; US
MAIERS, Eric J.; US
ONE, Jordan; US
Priority Data:
62/421,46214.11.2016US
62/484,75812.04.2017US
Title (EN) METHODS AND APPARATUS FOR A SHEAR-ENHANCED CNT-ASSEMBLY NANOSENSOR PLATFORM FOR ULTRA-SENSITIVE AND SELECTIVE PROTEIN DETECTION
(FR) PROCÉDÉS ET APPAREIL POUR UNE PLATE-FORME DE NANOCAPTEURS À ASSEMBLAGE DE NTC, AMÉLIORÉE PAR CISAILLEMENT POUR UNE DÉTECTION ULTRASENSIBLE ET SÉLECTIVE DE PROTÉINES
Abstract:
(EN) A nanoscale protein-sensing platform with a non-equilibrium on-off switch that employs dielectrophoretic and hydrodynamic shear forces to overcome these thermodynamic limitations with irreversible kinetics. The detection sensitivity is achieved with complete association of the antibody-antigen-antibody (Ab-Ag-Ab) complex by precisely and rapidly assembling carbon nanotubes (CNT) across two parallel electrodes via sequential DC electrophoresis and dielectrophoresis (DEP), and with single-CNT electron tunneling conductance. The high selectivity is achieved with a critical hydrodynamic shear rate between the activated dissociation shear rates of target and non-target linkers of the aligned CNTs.
(FR) L'invention concerne une plate-forme de détection de protéines à l'échelle nanométrique présentant un commutateur de marche/arrêt hors équilibre qui utilise des forces de cisaillement diélectrophorétiques et hydrodynamiques pour surmonter ces limitations thermodynamiques par une cinétique irréversible. La sensibilité de détection est obtenue par une association complète du complexe anticorps-antigène-anticorps (Ab-Ag-Ab) par assemblage précis et rapide de nanotubes de carbone (NTC) à travers deux électrodes parallèles par électrophorèse à courant continu et diélectrophorèse (DEP) séquentielles et présentant une conductance tunnel d'électrons par nanotube de carbone unique. La sélectivité élevée est obtenue avec un taux de cisaillement hydrodynamique critique entre les taux de cisaillement de dissociation activée de lieurs cibles et non cibles des NTC alignés.
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Designated States: AE, AG, AL, AM, AO, AT, AU, AZ, BA, BB, BG, BH, BN, BR, BW, BY, BZ, CA, CH, CL, CN, CO, CR, CU, CZ, DE, DJ, DK, DM, DO, DZ, EC, EE, EG, ES, FI, GB, GD, GE, GH, GM, GT, HN, HR, HU, ID, IL, IN, IR, IS, JO, JP, KE, KG, KH, KN, KP, KR, KW, KZ, LA, LC, LK, LR, LS, LU, LY, MA, MD, ME, MG, MK, MN, MW, MX, MY, MZ, NA, NG, NI, NO, NZ, OM, PA, PE, PG, PH, PL, PT, QA, RO, RS, RU, RW, SA, SC, SD, SE, SG, SK, SL, SM, ST, SV, SY, TH, TJ, TM, TN, TR, TT, TZ, UA, UG, US, UZ, VC, VN, ZA, ZM, ZW
African Regional Intellectual Property Organization (ARIPO) (BW, GH, GM, KE, LR, LS, MW, MZ, NA, RW, SD, SL, ST, SZ, TZ, UG, ZM, ZW)
Eurasian Patent Office (AM, AZ, BY, KG, KZ, RU, TJ, TM)
European Patent Office (EPO) (AL, AT, BE, BG, CH, CY, CZ, DE, DK, EE, ES, FI, FR, GB, GR, HR, HU, IE, IS, IT, LT, LU, LV, MC, MK, MT, NL, NO, PL, PT, RO, RS, SE, SI, SK, SM, TR)
African Intellectual Property Organization (BF, BJ, CF, CG, CI, CM, GA, GN, GQ, GW, KM, ML, MR, NE, SN, TD, TG)
Publication Language: English (EN)
Filing Language: English (EN)