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1. (WO2018090045) ANTIBODY-DRUG CONJUGATES
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Pub. No.: WO/2018/090045 International Application No.: PCT/US2017/061624
Publication Date: 17.05.2018 International Filing Date: 14.11.2017
IPC:
A61K 31/4545 (2006.01) ,C07D 513/04 (2006.01) ,C07K 19/00 (2006.01)
A HUMAN NECESSITIES
61
MEDICAL OR VETERINARY SCIENCE; HYGIENE
K
PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
31
Medicinal preparations containing organic active ingredients
33
Heterocyclic compounds
395
having nitrogen as a ring hetero atom, e.g. guanethidine, rifamycins
435
having six-membered rings with one nitrogen as the only ring hetero atom
44
Non-condensed pyridines; Hydrogenated derivatives thereof
445
Non-condensed piperidines, e.g. piperocaine
4523
containing further heterocyclic ring systems
4545
containing a six-membered ring with nitrogen as a ring hetero atom, e.g. pipamperone, anabasine
C CHEMISTRY; METALLURGY
07
ORGANIC CHEMISTRY
D
HETEROCYCLIC COMPOUNDS
513
Heterocyclic compounds containing in the condensed system at least one hetero ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for in groups C07D463/, C07D477/232
02
in which the condensed system contains two hetero rings
04
Ortho-condensed systems
C CHEMISTRY; METALLURGY
07
ORGANIC CHEMISTRY
K
PEPTIDES
19
Hybrid peptides
Applicants:
LIN, Nan-Horng [US/US]; US
CHO PHARMA INC; 18F, Building F, No. 3, Park Street Nankang District Taipei, 11503, TW
Inventors:
LIN, Nan-Horng; US
TSAI, Charng-Sheng; TW
HUNG, Ting-Chun; TW
CHUANG, Hong-Yang; TW
Agent:
LIANG, T., Chyau; US
Priority Data:
62/421,42914.11.2016US
Title (EN) ANTIBODY-DRUG CONJUGATES
(FR) CONJUGUÉS ANTICORPS-MÉDICAMENT
Abstract:
(EN) An antibody-drug conjugate (ADC) has a structure represented by Formula (I): a pharmaceutically acceptable salt thereof wherein Ab is an antibody without glycans (i.e., the protein portion an antibody); G1 and G2 are glycan moieties, which may be the same or different; Cn1 and Cn2 are conjugation moieties, which may be the same or different; L1 and L2 are linker moieties, which may be the same or different; D1 and D2; are drug units which may be the same or different; and x and y are independently an integer from 0 to 8, provided that x + y ≠ 0.
(FR) L'invention concerne un conjugué anticorps-médicament (CAM) possédant une structure représentée par la formule (I) : un sel de qualité pharmaceutique de ce dernier, dans laquelle Ab est un anticorps sans glycanes (c'est-à-dire la partie protéique d'un anticorps); G1 et G2 sont des fractions glycane, qui peuvent être identiques ou différentes; Cn1 et Cn2 sont des fractions de conjugaison, qui peuvent être identiques ou différentes; L1 et L2 sont des fractions de liaison, qui peuvent être identiques ou différentes; D1 et D2 sont des unités de médicament qui peuvent être identiques ou différentes; et x et y sont indépendamment un nombre entier de 0 à 8, à condition que x + y ≠ 0.
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Designated States: AE, AG, AL, AM, AO, AT, AU, AZ, BA, BB, BG, BH, BN, BR, BW, BY, BZ, CA, CH, CL, CN, CO, CR, CU, CZ, DE, DJ, DK, DM, DO, DZ, EC, EE, EG, ES, FI, GB, GD, GE, GH, GM, GT, HN, HR, HU, ID, IL, IN, IR, IS, JO, JP, KE, KG, KH, KN, KP, KR, KW, KZ, LA, LC, LK, LR, LS, LU, LY, MA, MD, ME, MG, MK, MN, MW, MX, MY, MZ, NA, NG, NI, NO, NZ, OM, PA, PE, PG, PH, PL, PT, QA, RO, RS, RU, RW, SA, SC, SD, SE, SG, SK, SL, SM, ST, SV, SY, TH, TJ, TM, TN, TR, TT, TZ, UA, UG, US, UZ, VC, VN, ZA, ZM, ZW
African Regional Intellectual Property Organization (ARIPO) (BW, GH, GM, KE, LR, LS, MW, MZ, NA, RW, SD, SL, ST, SZ, TZ, UG, ZM, ZW)
Eurasian Patent Office (AM, AZ, BY, KG, KZ, RU, TJ, TM)
European Patent Office (EPO) (AL, AT, BE, BG, CH, CY, CZ, DE, DK, EE, ES, FI, FR, GB, GR, HR, HU, IE, IS, IT, LT, LU, LV, MC, MK, MT, NL, NO, PL, PT, RO, RS, SE, SI, SK, SM, TR)
African Intellectual Property Organization (BF, BJ, CF, CG, CI, CM, GA, GN, GQ, GW, KM, ML, MR, NE, SN, TD, TG)
Publication Language: English (EN)
Filing Language: English (EN)