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1. (WO2018090006) METHODS FOR DRUG DISCOVERY USING STEM CELL-DERIVED SCHWANN CELLS
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Pub. No.: WO/2018/090006 International Application No.: PCT/US2017/061549
Publication Date: 17.05.2018 International Filing Date: 14.11.2017
IPC:
A61K 35/12 (2015.01) ,A61K 35/30 (2015.01) ,A61K 35/32 (2015.01) ,A61K 35/34 (2015.01) ,A61K 35/35 (2015.01) ,A61P 19/00 (2006.01)
[IPC code unknown for A61K 35/12][IPC code unknown for A61K 35/30][IPC code unknown for A61K 35/32][IPC code unknown for A61K 35/34][IPC code unknown for A61K 35/35][IPC code unknown for A61P 19]
Applicants:
MEMORIAL SLOAN-KETTERING CANCER CENTER [US/US]; 1275 York Avenue New York, NY 10065, US
CORNELL UNIVERSITY [US/US]; Center for Technology Licensing ("CTL") at Cornell University 395 Pine Tree Road, Suite 310 Ithaca, NY 14850, US
Inventors:
STUDER, Lorenz; US
FATTAHI, Faranak; US
GHAZIZADEH, Zaniar; US
CHEN, Shuibing; US
Agent:
KOLE, Lisa, B.; US
HAN, Yi; US
Priority Data:
62/421,81614.11.2016US
Title (EN) METHODS FOR DRUG DISCOVERY USING STEM CELL-DERIVED SCHWANN CELLS
(FR) PROCÉDÉS DE RECHERCHE DE NOUVEAUX MÉDICAMENTS UTILISANT DES CELLULES DE SCHWANN DÉRIVÉES DE CELLULES SOUCHES
Abstract:
(EN) The presently disclosed subject matter relates to use of Schwann cell precursors and Schwann cells derived from stem cells (e.g., human stem cells) for drug discovery in regeneration of peripheral nervous system (PNS) and/or central nervous system (CNS), prevention and/or repair myelin damages, and/or prevention and/or treatment of Schwann cell-related disorder (e.g., peripheral neuropathy diabetic peripheral neuropathy).
(FR) La présente invention concerne l'utilisation de précurseurs de cellules de Schwann et de cellules de Schwann dérivées de cellules souches (par exemple, des cellules souches humaines) pour la recherche de nouveaux médicaments dans la régénération du système nerveux périphérique (SNP) et/ou du système nerveux central (SNC), la prévention et/ou la réparation de lésions de la myéline, et/ou la prévention et/ou le traitement d'un trouble lié aux cellules de Schwann (par exemple, une neuropathie périphérique comme la neuropathie périphérique diabétique).
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Designated States: AE, AG, AL, AM, AO, AT, AU, AZ, BA, BB, BG, BH, BN, BR, BW, BY, BZ, CA, CH, CL, CN, CO, CR, CU, CZ, DE, DJ, DK, DM, DO, DZ, EC, EE, EG, ES, FI, GB, GD, GE, GH, GM, GT, HN, HR, HU, ID, IL, IN, IR, IS, JO, JP, KE, KG, KH, KN, KP, KR, KW, KZ, LA, LC, LK, LR, LS, LU, LY, MA, MD, ME, MG, MK, MN, MW, MX, MY, MZ, NA, NG, NI, NO, NZ, OM, PA, PE, PG, PH, PL, PT, QA, RO, RS, RU, RW, SA, SC, SD, SE, SG, SK, SL, SM, ST, SV, SY, TH, TJ, TM, TN, TR, TT, TZ, UA, UG, US, UZ, VC, VN, ZA, ZM, ZW
African Regional Intellectual Property Organization (ARIPO) (BW, GH, GM, KE, LR, LS, MW, MZ, NA, RW, SD, SL, ST, SZ, TZ, UG, ZM, ZW)
Eurasian Patent Office (AM, AZ, BY, KG, KZ, RU, TJ, TM)
European Patent Office (EPO) (AL, AT, BE, BG, CH, CY, CZ, DE, DK, EE, ES, FI, FR, GB, GR, HR, HU, IE, IS, IT, LT, LU, LV, MC, MK, MT, NL, NO, PL, PT, RO, RS, SE, SI, SK, SM, TR)
African Intellectual Property Organization (BF, BJ, CF, CG, CI, CM, GA, GN, GQ, GW, KM, ML, MR, NE, SN, TD, TG)
Publication Language: English (EN)
Filing Language: English (EN)