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1. (WO2018090004) TUBERCULOSIS THERAPEUTIC COMPOUNDS AND METHODS
Latest bibliographic data on file with the International Bureau    Submit observation

Pub. No.: WO/2018/090004 International Application No.: PCT/US2017/061544
Publication Date: 17.05.2018 International Filing Date: 14.11.2017
IPC:
A61K 31/497 (2006.01) ,A61K 9/12 (2006.01)
A HUMAN NECESSITIES
61
MEDICAL OR VETERINARY SCIENCE; HYGIENE
K
PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
31
Medicinal preparations containing organic active ingredients
33
Heterocyclic compounds
395
having nitrogen as a ring hetero atom, e.g. guanethidine, rifamycins
495
having six-membered rings with two nitrogen atoms as the only ring hetero atoms, e.g. piperazine
4965
Non-condensed pyrazines
497
containing further heterocyclic rings
A HUMAN NECESSITIES
61
MEDICAL OR VETERINARY SCIENCE; HYGIENE
K
PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
9
Medicinal preparations characterised by special physical form
10
Dispersions; Emulsions
12
Aerosols; Foams
Applicants: THE UNIVERSITY OF NORTH CAROLINA AT CHAPEL HILL[US/US]; 109 Church St. Chapel Hill, NC 27516, US
RESEARCH TRIANGLE INSTITUTE[US/US]; 3040 East Cornwallis Road Research Triangle Park, NC 27709-2194, US
Inventors: BRAUNSTEIN, Miriam; US
HICKEY, Anthony J.; US
YOUNG, Ellen; US
DURHAM, Phillip; US
Agent: LEGLEITER, Leon, R.; US
Priority Data:
62/421,62914.11.2016US
Title (EN) TUBERCULOSIS THERAPEUTIC COMPOUNDS AND METHODS
(FR) COMPOSÉS ET MÉTHODES THÉRAPEUTIQUES CONTRE LA TUBERCULOSE
Abstract:
(EN) Therapeutic compounds and methods for treating tuberculosis are provided. Methods of treating tuberculosis include administering to a subject an inhalable formulation of pyrazinoic acid, in some instances as an adjunctive therapy. As disclosed herein, inhaled pyrazinoic acid compositions provide an antibacterial effect on tuberculosis infection in the lung as well as inducing host-directed effects against tuberculosis in the spleen or liver. Disclosed tuberculosis treatments can target primary granulomatous lesions, whereas existing tuberculosis therapies target secondary granulomatous lesions.
(FR) L'invention concerne des composés thérapeutiques et des méthodes de traitement de la tuberculose. Des méthodes de traitement de la tuberculose comprennent l'administration à un sujet d'une formulation inhalable d'acide pyrazinoïque, dans certains cas en tant que thérapie d'appoint. Selon l'invention, des compositions d'acide pyrazinoïque inhalées assurent un effet antibactérien sur l'infection tuberculeuse touchant les poumons et induisent des effets visant l'hôte contre la tuberculose dans la rate ou le foie. Les traitements contre la tuberculose selon la présente invention peuvent cibler des lésions granulomateuses primaires, tandis que les traitements existants contre la tuberculose ciblent les lésions granulomateuses secondaires.
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Designated States: AE, AG, AL, AM, AO, AT, AU, AZ, BA, BB, BG, BH, BN, BR, BW, BY, BZ, CA, CH, CL, CN, CO, CR, CU, CZ, DE, DJ, DK, DM, DO, DZ, EC, EE, EG, ES, FI, GB, GD, GE, GH, GM, GT, HN, HR, HU, ID, IL, IN, IR, IS, JO, JP, KE, KG, KH, KN, KP, KR, KW, KZ, LA, LC, LK, LR, LS, LU, LY, MA, MD, ME, MG, MK, MN, MW, MX, MY, MZ, NA, NG, NI, NO, NZ, OM, PA, PE, PG, PH, PL, PT, QA, RO, RS, RU, RW, SA, SC, SD, SE, SG, SK, SL, SM, ST, SV, SY, TH, TJ, TM, TN, TR, TT, TZ, UA, UG, US, UZ, VC, VN, ZA, ZM, ZW
African Regional Intellectual Property Organization (ARIPO) (BW, GH, GM, KE, LR, LS, MW, MZ, NA, RW, SD, SL, ST, SZ, TZ, UG, ZM, ZW)
Eurasian Patent Office (AM, AZ, BY, KG, KZ, RU, TJ, TM)
European Patent Office (EPO) (AL, AT, BE, BG, CH, CY, CZ, DE, DK, EE, ES, FI, FR, GB, GR, HR, HU, IE, IS, IT, LT, LU, LV, MC, MK, MT, NL, NO, PL, PT, RO, RS, SE, SI, SK, SM, TR)
African Intellectual Property Organization (BF, BJ, CF, CG, CI, CM, GA, GN, GQ, GW, KM, ML, MR, NE, SN, TD, TG)
Publication Language: English (EN)
Filing Language: English (EN)