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1. (WO2018089996) COMPOSITION AND METHOD FOR IMPROVING SIGNAL-TO-NOISE IN HYBRIDIZATION TO OLIGONUCLEOTIDE ARRAYS
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Pub. No.: WO/2018/089996 International Application No.: PCT/US2017/061530
Publication Date: 17.05.2018 International Filing Date: 14.11.2017
IPC:
C12Q 1/68 (2006.01)
Applicants: AGILENT TECHNOLOGIES, INC.[US/US]; 5301 Stevens Creek Blvd. MS: 1A-PB Santa Clara, CA 95051-7201, US
Inventors: SAMPAS, Nicholas, M.; US
YAMA-DANG, Nazumi, Alice; US
ANDERSON, Paige; US
Agent: HARLIN, Michael, B.; US
ABERN, Holby, M.; US
ANDERSON, Eric, H.; US
BALDWIN, James, R.; US
CAMPBELL, Thomas, J.; US
Priority Data:
15/351,31214.11.2016US
Title (EN) COMPOSITION AND METHOD FOR IMPROVING SIGNAL-TO-NOISE IN HYBRIDIZATION TO OLIGONUCLEOTIDE ARRAYS
(FR) COMPOSITION ET PROCÉDÉ D'AMÉLIORATION DU RAPPORT SIGNAL SUR BRUIT DANS L'HYBRIDATION DE MATRICES D'OLIGONUCLÉOTIDES
Abstract: front page image
(EN) Provided herein, among other things, are compositions for improving signal-to-noise in hybridization to oligonucleotide arrays. In some embodiments, the composition may comprise a population of indexing oligonucleotides of formula X-Y, where the sequences of region X hybridize to an array and the sequences of region Y hybridize to distinct sites within a genomic region, transcript, set of transcripts, or complement of the same. Use of these oligonucleotides increases signal, reduces background and smoothens array hybridization analyses. Methods and kits that employ the compositions are also provided.
(FR) L'invention concerne, entre autres, des compositions aptes à améliorer le rapport signal sur bruit dans l'hybridation de matrices d'oligonucléotides. Dans certains modes de réalisation, la composition peut comprendre une population d'oligonucléotides d'indexation de formule X-Y, les séquences de la région X s'hybridant à une matrice et les séquences de la région Y s'hybridant à des sites distincts à l'intérieur d'une région génomique, un transcrit, un ensemble de transcrits, ou un complément de ceux-ci. L'utilisation de ces oligonucléotides améliore le signal, réduit l'arrière-plan, et lisse les analyses d'hybridation de la matrice. L'invention concerne également des procédés et des kits employant les compositions.
Designated States: AE, AG, AL, AM, AO, AT, AU, AZ, BA, BB, BG, BH, BN, BR, BW, BY, BZ, CA, CH, CL, CN, CO, CR, CU, CZ, DE, DJ, DK, DM, DO, DZ, EC, EE, EG, ES, FI, GB, GD, GE, GH, GM, GT, HN, HR, HU, ID, IL, IN, IR, IS, JO, JP, KE, KG, KH, KN, KP, KR, KW, KZ, LA, LC, LK, LR, LS, LU, LY, MA, MD, ME, MG, MK, MN, MW, MX, MY, MZ, NA, NG, NI, NO, NZ, OM, PA, PE, PG, PH, PL, PT, QA, RO, RS, RU, RW, SA, SC, SD, SE, SG, SK, SL, SM, ST, SV, SY, TH, TJ, TM, TN, TR, TT, TZ, UA, UG, US, UZ, VC, VN, ZA, ZM, ZW
African Regional Intellectual Property Organization (ARIPO) (BW, GH, GM, KE, LR, LS, MW, MZ, NA, RW, SD, SL, ST, SZ, TZ, UG, ZM, ZW)
Eurasian Patent Office (AM, AZ, BY, KG, KZ, RU, TJ, TM)
European Patent Office (EPO) (AL, AT, BE, BG, CH, CY, CZ, DE, DK, EE, ES, FI, FR, GB, GR, HR, HU, IE, IS, IT, LT, LU, LV, MC, MK, MT, NL, NO, PL, PT, RO, RS, SE, SI, SK, SM, TR)
African Intellectual Property Organization (BF, BJ, CF, CG, CI, CM, GA, GN, GQ, GW, KM, ML, MR, NE, SN, TD, TG)
Publication Language: English (EN)
Filing Language: English (EN)