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1. (WO2018089874) METHOD FOR CONTROLLING HEMATOPHAGOUS OR SAP-FEEDING ARTHROPODS

Pub. No.:    WO/2018/089874    International Application No.:    PCT/US2017/061247
Publication Date: Fri May 18 01:59:59 CEST 2018 International Filing Date: Tue Nov 14 00:59:59 CET 2017
IPC: A01P 7/04
A01N 43/50
A01N 25/04
Applicants: BOARD OF SUPERVISORS OF LOUISIANA STATE UNIVERSITY AND AGRICULTURAL AND MECHANICAL COLLEGE
SWALE, Daniel, R.
FOIL, Lane, D.
Inventors: SWALE, Daniel, R.
FOIL, Lane, D.
Title: METHOD FOR CONTROLLING HEMATOPHAGOUS OR SAP-FEEDING ARTHROPODS
Abstract:
Modulation of inward potassium ion conductance with structurally diverse small-molecules in the arthropod salivary gland induces arthropod salivary gland failure that results in a reduction or elimination in the ability of the arthropod to feed. Administering Kir channel inhibitors reduces food intake, increases feeding time, reduces salivary gland secretion, induces mortality, and reduces transmission of vector-borne pathogens. Kir channel inhibitors induce these adverse effects in ticks, mosquitoes, horn flies, and aphids.