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1. (WO2018089839) RAPID HIGH-RESOLUTION IMAGING METHODS FOR LARGE SAMPLES

Pub. No.:    WO/2018/089839    International Application No.:    PCT/US2017/061165
Publication Date: Fri May 18 01:59:59 CEST 2018 International Filing Date: Sat Nov 11 00:59:59 CET 2017
IPC: G02B 21/06
G02B 21/36
G01B 11/24
G01N 21/64
G02B 21/00
G02B 21/02
Applicants: THE TRUSTEES OF COLUMBIA UNIVERSITY IN THE CITY OF NEW YORK
Inventors: TOMER, Raju
Title: RAPID HIGH-RESOLUTION IMAGING METHODS FOR LARGE SAMPLES
Abstract:
Light Sheet Theta (LS-θ) Microscopy achieves large sample imaging capabilities without affecting the imaging depth or the image quality. An optical layout places a detection objective normal to the sample surface, while placing the illumination objectives that generate light sheets at an angle (theta) significantly smaller than 90 degrees. In this configuration, the light sheets enter from same side of the sample as the detection objective. The intersection of the light-sheet and the detection focal plane results in a line illumination-detection profile that is discriminated by a camera.