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1. (WO2018089830) EFFICIENT AND SCALABLE SYNTHESES OF NICOTINOYL RIBOSIDES AND REDUCED NICOTINOYL RIBOSIDES, MODIFIED DERIVATIVES THEREOF, PHOSPHORYLATED ANALOGS THEREOF, ADENYLYL DINUCLEOTIDE CONJUGATES THEREOF, AND NOVEL CRYSTALLINE FORMS THEREOF
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Pub. No.:    WO/2018/089830    International Application No.:    PCT/US2017/061154
Publication Date: 17.05.2018 International Filing Date: 10.11.2017
IPC:
A61K 31/455 (2006.01), A61K 31/706 (2006.01), C07H 1/00 (2006.01), C07H 19/048 (2006.01)
Applicants: THE QUEEN'S UNIVERSITY OF BELFAST [GB/GB]; University Road Belfast, NI BT7 1NN (GB).
CHROMADEX INC. [US/US]; 10005 Muirlands Blvd Suite G Irvine, CA 92618 (US)
Inventors: MIGAUD, Marie, Eugenie; (GB).
REDPATH, Philip; (GB).
CROSSEY, Kerri; (GB).
CUNNINGHAM, Richard; (GB).
ERICKSON, Aron; (US).
NYGAARD, Richard; (US).
STORJOHANN, Amanda; (US)
Agent: SUSSMAN, Adam, D.; (US).
CARRERA, JR., George, M.; (US).
BATZER, Brent, A.; (US).
KRIT, Jonathan, J.; (US).
CWIK, Joseph, E.; (US)
Priority Data:
62/420,737 11.11.2016 US
15/809,731 10.11.2017 US
15/809,753 10.11.2017 US
62/558,073 13.09.2017 US
Title (EN) EFFICIENT AND SCALABLE SYNTHESES OF NICOTINOYL RIBOSIDES AND REDUCED NICOTINOYL RIBOSIDES, MODIFIED DERIVATIVES THEREOF, PHOSPHORYLATED ANALOGS THEREOF, ADENYLYL DINUCLEOTIDE CONJUGATES THEREOF, AND NOVEL CRYSTALLINE FORMS THEREOF
(FR) SYNTHÈSES EFFICACES ET ÉVOLUTIVES DE NICOTINOYLE RIBOSIDES ET DE NICOTINOYLE RIBOSIDES RÉDUITS, DE LEURS DÉRIVÉS MODIFIÉS, DE LEURS ANALOGUES PHOSPHORYLÉS, DE LEURS CONJUGUÉS AVEC DE L'ADÉNYLYLE DINUCLÉOTIDE ET DE NOUVELLES FORMES CRISTALLINES DE CEUX-CI
Abstract: front page image
(EN)The present disclosure provides methods of making nicotinoyl riboside compounds or derivatives of formula (I): wherein X", Z 1, Z2, n, R 1, R2, R3, R4, R5, R6,, R7, and R 8 are described herein, reduced analogs thereof, modified derivatives thereof, phosphorylated analogs thereof, and adenylyl dinucleotide conjugates thereof, or salts, solvates, or prodrugs thereof; and novel crystalline forms thereof.
(FR)La présente invention concerne des procédés de fabrication de composés de nicotinoyle ribosides ou de dérivés de formule (I) : dans laquelle X", Z1, Z2, n, R1, R2, R3, R4, R5, R6,, R7 et R8 sont tels que décrits ici, d'analogues réduits de ceux-ci, de dérivés modifiés de ceux-ci, d'analogues phosphorylés de ceux-ci et de conjugués avec de l'adénylyle dinucléotide de ceux-ci, ou de sels, de solvates ou de promédicaments de ceux-ci et de nouvelles formes cristallines de ceux-ci.
Designated States: AE, AG, AL, AM, AO, AT, AU, AZ, BA, BB, BG, BH, BN, BR, BW, BY, BZ, CA, CH, CL, CN, CO, CR, CU, CZ, DE, DJ, DK, DM, DO, DZ, EC, EE, EG, ES, FI, GB, GD, GE, GH, GM, GT, HN, HR, HU, ID, IL, IN, IR, IS, JO, JP, KE, KG, KH, KN, KP, KR, KW, KZ, LA, LC, LK, LR, LS, LU, LY, MA, MD, ME, MG, MK, MN, MW, MX, MY, MZ, NA, NG, NI, NO, NZ, OM, PA, PE, PG, PH, PL, PT, QA, RO, RS, RU, RW, SA, SC, SD, SE, SG, SK, SL, SM, ST, SV, SY, TH, TJ, TM, TN, TR, TT, TZ, UA, UG, US, UZ, VC, VN, ZA, ZM, ZW.
African Regional Intellectual Property Organization (BW, GH, GM, KE, LR, LS, MW, MZ, NA, RW, SD, SL, ST, SZ, TZ, UG, ZM, ZW)
Eurasian Patent Organization (AM, AZ, BY, KG, KZ, RU, TJ, TM)
European Patent Office (AL, AT, BE, BG, CH, CY, CZ, DE, DK, EE, ES, FI, FR, GB, GR, HR, HU, IE, IS, IT, LT, LU, LV, MC, MK, MT, NL, NO, PL, PT, RO, RS, SE, SI, SK, SM, TR)
African Intellectual Property Organization (BF, BJ, CF, CG, CI, CM, GA, GN, GQ, GW, KM, ML, MR, NE, SN, TD, TG).
Publication Language: English (EN)
Filing Language: English (EN)