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1. (WO2018089786) ATG7 INHIBITORS AND THE USES THEREOF

Pub. No.:    WO/2018/089786    International Application No.:    PCT/US2017/061094
Publication Date: Fri May 18 01:59:59 CEST 2018 International Filing Date: Sat Nov 11 00:59:59 CET 2017
IPC: C07D 487/04
A61K 31/519
Applicants: MILLENNIUM PHARMACEUTICALS, INC.
Inventors: ADHIKARI, Sharmila
CALDERWOOD, Emily, Frances
ENGLAND, Dylan, Bradley
GOULD, Alexandra, E.
HARRISON, Sean, J.
HUANG, Shih-Chung
MA, Liting
Title: ATG7 INHIBITORS AND THE USES THEREOF
Abstract:
Disclosed are chemical entities which are compounds of formula (I) : or a pharmaceutically acceptable salt thereof, wherein R1, R2, and Ra have the values described herein. Chemical entities according to the disclosure can be useful as inhibitors of ATG7. Further provided are pharmaceutical compositions comprising a chemical entity of the disclosure and methods of using the compositions in the treatment of cancer.