Search International and National Patent Collections

1. (WO2018089783) AUTOMATED STEREOLOGY FOR DETERMINING TISSUE CHARACTERISTICS

Pub. No.:    WO/2018/089783    International Application No.:    PCT/US2017/061090
Publication Date: Fri May 18 01:59:59 CEST 2018 International Filing Date: Sat Nov 11 00:59:59 CET 2017
IPC: H04N 13/02
G06K 9/00
Applicants: UNIVERSITY OF SOUTH FLORIDA
STEREOLOGY RESOURCE CENTER, INC.
Inventors: MOUTON, Peter, Randolph
PHOULADY, Hady, Ahmady
GOLDGOF, Dmitry
HALL, Lawrence, O.
Title: AUTOMATED STEREOLOGY FOR DETERMINING TISSUE CHARACTERISTICS
Abstract:
Systems and methods for automated stereology are provided. A method can include providing an imager for capturing a Z-stack of images of a three-dimensional (3D) object,; constructing extended depth of field (EDF) images from the Z-stack of images; performing a segmentation method on the EDF images including estimating a Gaussian Mixture Model (GMM), performing morphological operations, performing watershed segmentation, constructing Voronoi diagrams and perfomiing boundary smoothing; and determining one or more stereology parameters such as number of cells in a region.