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1. (WO2018089780) ANTI-PD-L1 AND ANTI-CTLA-4 ANTIBODIES FOR TREATING NON-SMALL CELL LUNG CANCER

Pub. No.:    WO/2018/089780    International Application No.:    PCT/US2017/061085
Publication Date: Fri May 18 01:59:59 CEST 2018 International Filing Date: Sat Nov 11 00:59:59 CET 2017
IPC: A61K 39/00
C07K 16/28
C12Q 1/68
G01N 33/50
G01N 33/574
Applicants: MEDIMMUNE, LLC
DEFINIENS AG
Inventors: STEELE, Keith
WU, Song
HIGGS, Brandon
WIDMAIER, Moritz
ALTHAMMER, Sonja
KORN, Rene
SPITZMUELLER, Andreas
Title: ANTI-PD-L1 AND ANTI-CTLA-4 ANTIBODIES FOR TREATING NON-SMALL CELL LUNG CANCER
Abstract:
Provided herein are methods of treating non-small cell lung cancers comprising administering an effective amount of durvalumab (MEDI4736) or an antigen-binding fragment thereof and tremelimumab or an antigen-binding fragment thereof. A combination of durvalumab and tremelimumab was effective at treating non-small cell lung cancers characterized as PD-L1- and having a high level of CD8+ tumor-infiltrating lymphocytes