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1. (WO2018089715) ACTIVIN RECEPTOR TYPE IIA VARIANTS AND METHODS OF USE THEREOF
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Pub. No.: WO/2018/089715 International Application No.: PCT/US2017/060970
Publication Date: 17.05.2018 International Filing Date: 09.11.2017
IPC:
A61K 38/00 (2006.01) ,A61K 38/17 (2006.01) ,A61K 38/18 (2006.01)
A HUMAN NECESSITIES
61
MEDICAL OR VETERINARY SCIENCE; HYGIENE
K
PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
38
Medicinal preparations containing peptides
A HUMAN NECESSITIES
61
MEDICAL OR VETERINARY SCIENCE; HYGIENE
K
PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
38
Medicinal preparations containing peptides
16
Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
17
from animals; from humans
A HUMAN NECESSITIES
61
MEDICAL OR VETERINARY SCIENCE; HYGIENE
K
PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
38
Medicinal preparations containing peptides
16
Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
17
from animals; from humans
18
Growth factors; Growth regulators
Applicants: KEROS THERAPEUTICS, INC.[US/US]; One Kendall Square, Building 1400W, Suite 14303 Cambridge, MA 02139, US
Inventors: SEEHRA, Jasbir, S.; US
LACHEY, Jennifer; US
Agent: BIEKER-BRADY, Kristina; US
Priority Data:
62/420,47610.11.2016US
62/531,94313.07.2017US
Title (EN) ACTIVIN RECEPTOR TYPE IIA VARIANTS AND METHODS OF USE THEREOF
(FR) VARIANTS DE TYPE IIA DU RÉCEPTEUR DE L'ACTIVINE ET LEURS MÉTHODES D'UTILISATION
Abstract:
(EN) The invention features polypeptides that include an extracellular ActRlla variant. In some embodiments, a polypeptide of the invention includes an extracellular ActRlla variant fused to an Fc domain monomer or moiety. The invention also features pharmaceutical compositions and methods of using the polypeptides to treat diseases and conditions involving bone damage, e.g., primary osteoporosis, secondary osteoporosis, osteopenia, osteopetrosis, facture, bone cancer or cancer metastasis-related bone loss, Paget's disease, renal osteodystrophy, treatment-related bone loss, diet- related bone loss, bone loss associated with the treatment of obesity, low gravity-related bone loss, or immobility-related bone loss.
(FR) L'invention concerne des polypeptides qui comprennent un variant d'ActRlla extracellulaire. Dans certains modes de réalisation, un polypeptide de l'invention comprend un variant d'ActRlla extracellulaire fusionné à un monomère ou à une fraction de domaine Fc. L'invention concerne également des compositions pharmaceutiques et des méthodes d'utilisation des polypeptides dans le traitement de maladies et d'états pathologiques impliquant des lésions osseuses, par exemple, l'ostéoporose primaire, l'ostéoporose secondaire, l'ostéopénie, l'ostéopétrose, une fracture, le cancer des os ou la perte osseuse liée à la métastase cancéreuse, la maladie de Paget, l'ostéodystrophie rénale, la perte osseuse liée à un traitement, la perte osseuse liée à un régime, la perte osseuse associée au traitement de l'obésité, la perte osseuse liée à une faible force de gravité, ou la perte osseuse liée à l'immobilité.
Designated States: AE, AG, AL, AM, AO, AT, AU, AZ, BA, BB, BG, BH, BN, BR, BW, BY, BZ, CA, CH, CL, CN, CO, CR, CU, CZ, DE, DJ, DK, DM, DO, DZ, EC, EE, EG, ES, FI, GB, GD, GE, GH, GM, GT, HN, HR, HU, ID, IL, IN, IR, IS, JO, JP, KE, KG, KH, KN, KP, KR, KW, KZ, LA, LC, LK, LR, LS, LU, LY, MA, MD, ME, MG, MK, MN, MW, MX, MY, MZ, NA, NG, NI, NO, NZ, OM, PA, PE, PG, PH, PL, PT, QA, RO, RS, RU, RW, SA, SC, SD, SE, SG, SK, SL, SM, ST, SV, SY, TH, TJ, TM, TN, TR, TT, TZ, UA, UG, US, UZ, VC, VN, ZA, ZM, ZW
African Regional Intellectual Property Organization (ARIPO) (BW, GH, GM, KE, LR, LS, MW, MZ, NA, RW, SD, SL, ST, SZ, TZ, UG, ZM, ZW)
Eurasian Patent Office (AM, AZ, BY, KG, KZ, RU, TJ, TM)
European Patent Office (EPO) (AL, AT, BE, BG, CH, CY, CZ, DE, DK, EE, ES, FI, FR, GB, GR, HR, HU, IE, IS, IT, LT, LU, LV, MC, MK, MT, NL, NO, PL, PT, RO, RS, SE, SI, SK, SM, TR)
African Intellectual Property Organization (BF, BJ, CF, CG, CI, CM, GA, GN, GQ, GW, KM, ML, MR, NE, SN, TD, TG)
Publication Language: English (EN)
Filing Language: English (EN)