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1. (WO2018089628) ANTI-OX40 ANTIBODIES, ANTI-GITR ANTIBODIES, AND METHODS OF USE THEREOF

Pub. No.:    WO/2018/089628    International Application No.:    PCT/US2017/060854
Publication Date: Fri May 18 01:59:59 CEST 2018 International Filing Date: Fri Nov 10 00:59:59 CET 2017
IPC: A61K 39/395
C07K 16/28
C07K 16/00
Applicants: AGENUS INC.
MEMORIAL SLOAN-KETTERING CANCER CENTER
LUDWIG INSTITUTE FOR CANCER RESEARCH LTD.
Inventors: WILSON, Nicholas S.
WAIGHT, Jeremy D.
UNDERWOOD, Dennis J.
BREOUS-NYSTROM, Ekaterina V.
RITTER, Gerd
SCHAER, David
HIRSCHHORN-CYMERMAN, Daniel
MERGHOUB, Taha
VAN DIJK, Marc
Title: ANTI-OX40 ANTIBODIES, ANTI-GITR ANTIBODIES, AND METHODS OF USE THEREOF
Abstract:
The present disclosure provides antibodies that specifically bind to human OX40 receptor (OX40) and/or human GITR receptor (GITR), including multispecific antibodies that bind, e.g., to OX40 and GITR, and compositions comprising such antibodies. The antibodies disclosed herein modulate OX40 and/or GITR activity e.g., enhance, activate, induce, reduce, deactivate, or inhibit OX40 and/or GITR activity. The present disclosure also provides methods for treating disorders, such as cancer, autoimmune diseases or disorders, or inflammatory diseases or disorders, by administering an antibody that specifically binds to human OX40 and/or human GITR and modulates OX40 and/or GITR activity.