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1. (WO2018089628) ANTI-OX40 ANTIBODIES, ANTI-GITR ANTIBODIES, AND METHODS OF USE THEREOF
Latest bibliographic data on file with the International Bureau    Submit observation

Pub. No.: WO/2018/089628 International Application No.: PCT/US2017/060854
Publication Date: 17.05.2018 International Filing Date: 09.11.2017
IPC:
A61K 39/395 (2006.01) ,C07K 16/28 (2006.01) ,C07K 16/00 (2006.01)
Applicants: AGENUS INC.[US/US]; 3 Forbes Road Lexington, Massachusetts 02421, US
MEMORIAL SLOAN-KETTERING CANCER CENTER[US/US]; 1275 York Avenue New York, New York 10065, US
LUDWIG INSTITUTE FOR CANCER RESEARCH LTD.[CH/CH]; Stadelhoferstrasse 22 8001 Zurich, CH
Inventors: WILSON, Nicholas S.; US
WAIGHT, Jeremy D.; US
UNDERWOOD, Dennis J.; US
BREOUS-NYSTROM, Ekaterina V.; CH
RITTER, Gerd; US
SCHAER, David; US
HIRSCHHORN-CYMERMAN, Daniel; US
MERGHOUB, Taha; US
VAN DIJK, Marc; NL
Agent: STEFFE, Eric K.; US
BANOWIT, Donald R.; US
BEZOS, Salvador M.; US
BODENSTEIN, Matthew; US
CALVO, Paul A.; US
CAMARCE, Christian; US
CIMBALA, Michele A.; US
COLLER III, Richard D.; US
CONKLIN, Kyle; US
CORNWELL, David K.S.; US
COVERT, John M.; US
DURKIN, Tracy-Gene G.; US
EISENBERG, Jason D.; US
ELLISON, Eldora L.; US
ESMOND, Robert W.; US
FEATHERSTONE, Donald J.; US
FRUEAUF, Jeremiah B.; US
GILLENTINE, Marsha Rose; US
GOLDSTEIN, Jorge A.; US
GORDON, Lori A.; US
HELVEY, Jeffrey T.; US
HICKS, Ross; US
HOLOUBEK, Michelle K.; US
JACKMAN, Peter A.; US
KIM, Ji-Eun; US
LEE, Michael Q.; US
LONGSWORTH, Gaby L.; US
MESSINGER, Michael V.; US
MILLONIG, Robert C.; US
MUTSCHELKNAUS, Joseph; US
NANNENGA-COMBS, Bonnie; US
RAY, Michael B.; US
RYGIEL, Mark W.; US
SHEA JR., Timothy J.; US
SOKOHL, Robert E.; US
SPECHT, Michael D.; US
STERLING, Deborah A.; US
STERNE, Robert Greene; US
Priority Data:
62/419,90709.11.2016US
Title (EN) ANTI-OX40 ANTIBODIES, ANTI-GITR ANTIBODIES, AND METHODS OF USE THEREOF
(FR) ANTICORPS ANTI-OX40, ANTICORPS ANTI-GITR, ET LEURS PROCÉDÉS D'UTILISATION
Abstract:
(EN) The present disclosure provides antibodies that specifically bind to human OX40 receptor (OX40) and/or human GITR receptor (GITR), including multispecific antibodies that bind, e.g., to OX40 and GITR, and compositions comprising such antibodies. The antibodies disclosed herein modulate OX40 and/or GITR activity e.g., enhance, activate, induce, reduce, deactivate, or inhibit OX40 and/or GITR activity. The present disclosure also provides methods for treating disorders, such as cancer, autoimmune diseases or disorders, or inflammatory diseases or disorders, by administering an antibody that specifically binds to human OX40 and/or human GITR and modulates OX40 and/or GITR activity.
(FR) La présente divulgation concerne des anticorps qui se lient spécifiquement au récepteur OX40 humain (OX40) et/ou au récepteur GITR humain (GITR), comprenant des anticorps multispécifiques qui se lient, p. ex., à OX40 et GITR, et des compositions les contenant. Les anticorps ci-décrits modulent l'activité OX40 et/ou l'activité GITR, p. ex., améliorent, activent, induisent, réduisent, désactivent ou inhibent l'activité OX40 et/ou GITR. Des méthodes destinées à traiter des troubles, tels que le cancer, des maladies ou troubles auto-immuns, ou des maladies ou troubles inflammatoires, par administration d'un anticorps qui se lie spécifiquement au récepteur OX40 humain et/ou au récepteur GITR humain et module l'activité OX40 et/ou GITR sont en outre décrites.
Designated States: AE, AG, AL, AM, AO, AT, AU, AZ, BA, BB, BG, BH, BN, BR, BW, BY, BZ, CA, CH, CL, CN, CO, CR, CU, CZ, DE, DJ, DK, DM, DO, DZ, EC, EE, EG, ES, FI, GB, GD, GE, GH, GM, GT, HN, HR, HU, ID, IL, IN, IR, IS, JO, JP, KE, KG, KH, KN, KP, KR, KW, KZ, LA, LC, LK, LR, LS, LU, LY, MA, MD, ME, MG, MK, MN, MW, MX, MY, MZ, NA, NG, NI, NO, NZ, OM, PA, PE, PG, PH, PL, PT, QA, RO, RS, RU, RW, SA, SC, SD, SE, SG, SK, SL, SM, ST, SV, SY, TH, TJ, TM, TN, TR, TT, TZ, UA, UG, US, UZ, VC, VN, ZA, ZM, ZW
African Regional Intellectual Property Organization (ARIPO) (BW, GH, GM, KE, LR, LS, MW, MZ, NA, RW, SD, SL, ST, SZ, TZ, UG, ZM, ZW)
Eurasian Patent Office (AM, AZ, BY, KG, KZ, RU, TJ, TM)
European Patent Office (EPO) (AL, AT, BE, BG, CH, CY, CZ, DE, DK, EE, ES, FI, FR, GB, GR, HR, HU, IE, IS, IT, LT, LU, LV, MC, MK, MT, NL, NO, PL, PT, RO, RS, SE, SI, SK, SM, TR)
African Intellectual Property Organization (BF, BJ, CF, CG, CI, CM, GA, GN, GQ, GW, KM, ML, MR, NE, SN, TD, TG)
Publication Language: English (EN)
Filing Language: English (EN)