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1. (WO2018089544) ISOQUINOLINE AMINE COMPOUNDS AS MGLUR4 ALLOSTERIC POTENTIATORS, COMPOSITIONS, AND METHODS OF TREATING NEUROLOGICAL DYSFUNCTION
Latest bibliographic data on file with the International Bureau    Submit observation

Pub. No.: WO/2018/089544 International Application No.: PCT/US2017/060711
Publication Date: 17.05.2018 International Filing Date: 08.11.2017
IPC:
A61K 31/415 (2006.01) ,A61K 31/4162 (2006.01) ,A61K 31/4725 (2006.01) ,C07D 401/12 (2006.01) ,C07D 471/04 (2006.01)
Applicants: VANDERBILT UNIVERSITY[US/US]; 305 Kirkland Hall Nashville, Tennessee 37240, US
Inventors: CONN, P., Jeffrey; US
LINDSLEY, Craig, W.; US
FELTS, Andrew; US
Agent: MYERS, Richard S., Jr.; US
DECKER, Mandy Wilson; US
HAEBERLIN, Jeffrey; US
HAYNE, James; US
NAGLE, JR., David; US
RITCHIE, Sean P.; US
TRENKLE, Nicholas; US
WEYER, Stephen J.; US
WRIGHT, Terry; US
Priority Data:
62/419,21708.11.2016US
Title (EN) ISOQUINOLINE AMINE COMPOUNDS AS MGLUR4 ALLOSTERIC POTENTIATORS, COMPOSITIONS, AND METHODS OF TREATING NEUROLOGICAL DYSFUNCTION
(FR) COMPOSÉS D'AMINE ISOQUINOLINE EN TANT QUE POTENTIALISATEURS ALLOSTÉRIQUES DE MGLUR4, COMPOSITIONS, ET MÉTHODES DE TRAITEMENT DE DYSFONCTIONNEMENTS NEUROLOGIQUES
Abstract:
(EN) Isoquinoline amine compounds which are useful as allosteric potentiators/positive allosteric modulators of the metabotropic glutamate receptor subtype 4 (mGluR4); synthetic methods for making the compounds; pharmaceutical compositions comprising the compounds; and methods of using the compounds, for example, in treating neurological and psychiatric disorders or other disease state associated with glutamate dysfunction.
(FR) L'invention concerne des composés d'amine isoquinoline utilisables comme potentialisateurs allostériques/modulateurs allostériques positifs du sous-type 4 des récepteurs métabotropiques du glutamate (mGluR4); des méthodes de synthèse pour l'élaboration de ces composés; des compositions pharmaceutiques contenant ces composés; et des méthodes d'utilisation de ces composés, par exemple pour le traitement de troubles neurologiques et psychiatriques ou d'autres états pathologiques associés à un dysfonctionnement glutamatergique.
Designated States: AE, AG, AL, AM, AO, AT, AU, AZ, BA, BB, BG, BH, BN, BR, BW, BY, BZ, CA, CH, CL, CN, CO, CR, CU, CZ, DE, DJ, DK, DM, DO, DZ, EC, EE, EG, ES, FI, GB, GD, GE, GH, GM, GT, HN, HR, HU, ID, IL, IN, IR, IS, JO, JP, KE, KG, KH, KN, KP, KR, KW, KZ, LA, LC, LK, LR, LS, LU, LY, MA, MD, ME, MG, MK, MN, MW, MX, MY, MZ, NA, NG, NI, NO, NZ, OM, PA, PE, PG, PH, PL, PT, QA, RO, RS, RU, RW, SA, SC, SD, SE, SG, SK, SL, SM, ST, SV, SY, TH, TJ, TM, TN, TR, TT, TZ, UA, UG, US, UZ, VC, VN, ZA, ZM, ZW
African Regional Intellectual Property Organization (ARIPO) (BW, GH, GM, KE, LR, LS, MW, MZ, NA, RW, SD, SL, ST, SZ, TZ, UG, ZM, ZW)
Eurasian Patent Office (AM, AZ, BY, KG, KZ, RU, TJ, TM)
European Patent Office (EPO) (AL, AT, BE, BG, CH, CY, CZ, DE, DK, EE, ES, FI, FR, GB, GR, HR, HU, IE, IS, IT, LT, LU, LV, MC, MK, MT, NL, NO, PL, PT, RO, RS, SE, SI, SK, SM, TR)
African Intellectual Property Organization (BF, BJ, CF, CG, CI, CM, GA, GN, GQ, GW, KM, ML, MR, NE, SN, TD, TG)
Publication Language: English (EN)
Filing Language: English (EN)