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1. (WO2018089540) STABILIZED FORMULATIONS OF LIPID NANOPARTICLES

Pub. No.:    WO/2018/089540    International Application No.:    PCT/US2017/060704
Publication Date: Fri May 18 01:59:59 CEST 2018 International Filing Date: Thu Nov 09 00:59:59 CET 2017
IPC: A61K 9/00
A61K 9/19
A61K 48/00
A61K 9/51
Applicants: MODERNATX, INC.
Inventors: BRADER, Mark
Title: STABILIZED FORMULATIONS OF LIPID NANOPARTICLES
Abstract:
The disclosure features a lipid nanoparticle (LNP) formulation comprising a plurality of LNPs and a stabilizing agent that mitigates the degradation of the LNPs or a subpopulation thereof. Lipid nanoparticles further including therapeutics and/or prophylactics such as RNA are useful in the delivery of therapeutics and/or prophylactics to mammalian cells or organs to, for example, regulate polypeptide, protein, or gene expression. Methods of manufacturing LNP formulations and screening for a stabilizing agent are also disclosed.