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1. (WO2018089540) STABILIZED FORMULATIONS OF LIPID NANOPARTICLES
Latest bibliographic data on file with the International Bureau    Submit observation

Pub. No.:    WO/2018/089540    International Application No.:    PCT/US2017/060704
Publication Date: 17.05.2018 International Filing Date: 08.11.2017
IPC:
A61K 9/00 (2006.01), A61K 9/19 (2006.01), A61K 48/00 (2006.01), A61K 9/51 (2006.01)
Applicants: MODERNATX, INC. [US/US]; 200 Technology Square Cambridge, Massachusetts 02139 (US)
Inventors: BRADER, Mark; (US)
Agent: ERLACHER, Heidi, A.; (US).
PEMBERTON, Christine C.; (US).
SUN, XiXi; (US)
Priority Data:
62/419,459 08.11.2016 US
Title (EN) STABILIZED FORMULATIONS OF LIPID NANOPARTICLES
(FR) FORMULATIONS STABILISÉES DE NANOPARTICULES LIPIDIQUES
Abstract: front page image
(EN)The disclosure features a lipid nanoparticle (LNP) formulation comprising a plurality of LNPs and a stabilizing agent that mitigates the degradation of the LNPs or a subpopulation thereof. Lipid nanoparticles further including therapeutics and/or prophylactics such as RNA are useful in the delivery of therapeutics and/or prophylactics to mammalian cells or organs to, for example, regulate polypeptide, protein, or gene expression. Methods of manufacturing LNP formulations and screening for a stabilizing agent are also disclosed.
(FR)L'invention concerne une formulation de nanoparticules lipidiques (LNP) comprenant une pluralité de LNPs et un agent de stabilisation qui atténue la dégradation des LNPs ou une sous-population de ceux-ci. Les nanoparticules lipidiques comprenant en outre des agents thérapeutiques et/ou prophylactiques tels que de l'ARN sont utiles dans l'administration d'agents thérapeutiques et/ou prophylactiques à des cellules ou des organes de mammifères pour, par exemple, réguler l'expression de polypeptides, de protéines, ou de gènes. L'invention concerne également des procédés de fabrication de formulations de LNP et Le criblage d'un agent de stabilisation.
Designated States: AE, AG, AL, AM, AO, AT, AU, AZ, BA, BB, BG, BH, BN, BR, BW, BY, BZ, CA, CH, CL, CN, CO, CR, CU, CZ, DE, DJ, DK, DM, DO, DZ, EC, EE, EG, ES, FI, GB, GD, GE, GH, GM, GT, HN, HR, HU, ID, IL, IN, IR, IS, JO, JP, KE, KG, KH, KN, KP, KR, KW, KZ, LA, LC, LK, LR, LS, LU, LY, MA, MD, ME, MG, MK, MN, MW, MX, MY, MZ, NA, NG, NI, NO, NZ, OM, PA, PE, PG, PH, PL, PT, QA, RO, RS, RU, RW, SA, SC, SD, SE, SG, SK, SL, SM, ST, SV, SY, TH, TJ, TM, TN, TR, TT, TZ, UA, UG, US, UZ, VC, VN, ZA, ZM, ZW.
African Regional Intellectual Property Organization (BW, GH, GM, KE, LR, LS, MW, MZ, NA, RW, SD, SL, ST, SZ, TZ, UG, ZM, ZW)
Eurasian Patent Organization (AM, AZ, BY, KG, KZ, RU, TJ, TM)
European Patent Office (AL, AT, BE, BG, CH, CY, CZ, DE, DK, EE, ES, FI, FR, GB, GR, HR, HU, IE, IS, IT, LT, LU, LV, MC, MK, MT, NL, NO, PL, PT, RO, RS, SE, SI, SK, SM, TR)
African Intellectual Property Organization (BF, BJ, CF, CG, CI, CM, GA, GN, GQ, GW, KM, ML, MR, NE, SN, TD, TG).
Publication Language: English (EN)
Filing Language: English (EN)