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1. (WO2018089512) METHODS FOR CONTINUOUS SORTING OF CELLS BASED ON MOLECULAR ADHESION

Pub. No.:    WO/2018/089512    International Application No.:    PCT/US2017/060662
Publication Date: Fri May 18 01:59:59 CEST 2018 International Filing Date: Thu Nov 09 00:59:59 CET 2017
IPC: B01L 3/00
G01N 1/34
G01N 33/48
G01N 33/483
Applicants: GEORGIA TECH RESEARCH CORPORATION
Inventors: SULCHEK, Todd
ALEXEEV, Alexander
TASADDUQ, Bushra
Title: METHODS FOR CONTINUOUS SORTING OF CELLS BASED ON MOLECULAR ADHESION
Abstract:
Embodiments of the present disclosure can include a method comprising: providing a plurality of cells to a microchannel, the microchannel coated in at least one cell adhesion entity and comprising a compressive surface and a first outlet, the compressive surface defining a compression gap, flowing the plurality of cells through the microchannel, wherein the flowing comprises: compressing the plurality of cells underneath the compressive surface; and exposing the plurality of cells to the at least one cell adhesion entity, wherein the exposing causes a first portion of the cells having a first adhesion property to temporarily bind to the cell adhesion entity; and collecting the first portion of cells at the first outlet; wherein the compression gap has a height of from 75% to 95% an average diameter of the plurality of cells.