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1. (WO2018089495) ENCAPSULATION OF PHOSPHODIESTERASE INHIBITORS TO TREAT ALCOHOLIC LIVER DISEASE
Latest bibliographic data on file with the International Bureau    Submit observation

Pub. No.:    WO/2018/089495    International Application No.:    PCT/US2017/060642
Publication Date: 17.05.2018 International Filing Date: 08.11.2017
IPC:
A61K 9/127 (2006.01), A61K 31/70 (2006.01), A61P 1/16 (2006.01)
Applicants: UNIVERSITY OF LOUISVILLE RESEARCH FOUNDATION, INC. [US/US]; Office of Technology Transfer 300 East Market Street, Suite 300 Louisville, Kentucky 40202 (US)
Inventors: MALDONADO, Claudio; (US).
MCCLAIN, Craig; (US).
BARVE, Shirish S.; (US).
GOBEJISHVILI, Leila; (US).
BAUER, Philip; (US)
Agent: DECKER, Mandy W.; (US).
RITCHIE, Sean P.; (US).
WRIGHT, Terry L.; (US).
HAEBERLIN, Jeffrey A.; (US).
NAGLE, JR., David W.; (US)
Priority Data:
62/419,114 08.11.2016 US
Title (EN) ENCAPSULATION OF PHOSPHODIESTERASE INHIBITORS TO TREAT ALCOHOLIC LIVER DISEASE
(FR) ENCAPSULATION D’INHIBITEURS DE PHOSPHODIESTÉRASE POUR TRAITER LA MALADIE HÉPATIQUE ALCOOLIQUE
Abstract: front page image
(EN)Provided herein are compositions for treating liver inflammation. The compositions include a biologically active phosphodiesterase 4 (PDE4) inhibitor and a liposome, the liposome encapsulating the PDE4 inhibitor. The liposome may be anionic and include both neutrally charged and negatively charged phospholipids. Encapsulation of the PDE4 inhibitor in the liposome facilitates targeted delivery to the liver while limiting access to the central nervous system.
(FR)La présente invention concerne des compositions destinées à traiter l’inflammation hépatique. Les compositions comprennent un inhibiteur phosphodiestérase (4) (PDE4) biologiquement actif et un liposome, le liposome encapsulant l’inhibiteur (PDE4). Le liposome peut être anionique et comprend à la fois des phospholipides neutres et négativement chargés. L’encapsulation de l’inhibiteur (PDE4) dans le liposome facilite l’administration ciblée au foie tout en réduisant l’accès au système nerveux central.
Designated States: AE, AG, AL, AM, AO, AT, AU, AZ, BA, BB, BG, BH, BN, BR, BW, BY, BZ, CA, CH, CL, CN, CO, CR, CU, CZ, DE, DJ, DK, DM, DO, DZ, EC, EE, EG, ES, FI, GB, GD, GE, GH, GM, GT, HN, HR, HU, ID, IL, IN, IR, IS, JO, JP, KE, KG, KH, KN, KP, KR, KW, KZ, LA, LC, LK, LR, LS, LU, LY, MA, MD, ME, MG, MK, MN, MW, MX, MY, MZ, NA, NG, NI, NO, NZ, OM, PA, PE, PG, PH, PL, PT, QA, RO, RS, RU, RW, SA, SC, SD, SE, SG, SK, SL, SM, ST, SV, SY, TH, TJ, TM, TN, TR, TT, TZ, UA, UG, US, UZ, VC, VN, ZA, ZM, ZW.
African Regional Intellectual Property Organization (BW, GH, GM, KE, LR, LS, MW, MZ, NA, RW, SD, SL, ST, SZ, TZ, UG, ZM, ZW)
Eurasian Patent Organization (AM, AZ, BY, KG, KZ, RU, TJ, TM)
European Patent Office (AL, AT, BE, BG, CH, CY, CZ, DE, DK, EE, ES, FI, FR, GB, GR, HR, HU, IE, IS, IT, LT, LU, LV, MC, MK, MT, NL, NO, PL, PT, RO, RS, SE, SI, SK, SM, TR)
African Intellectual Property Organization (BF, BJ, CF, CG, CI, CM, GA, GN, GQ, GW, KM, ML, MR, NE, SN, TD, TG).
Publication Language: English (EN)
Filing Language: English (EN)