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1. (WO2018089472) METHODS AND COMPOSITIONS USEFUL IN DETECTING PROTEINS

Pub. No.:    WO/2018/089472    International Application No.:    PCT/US2017/060609
Publication Date: Fri May 18 01:59:59 CEST 2018 International Filing Date: Thu Nov 09 00:59:59 CET 2017
IPC: A61K 38/00
G01N 33/566
Applicants: BEATTY, Kimberly
ZANE, Hannah
DOH, Julia
Inventors: BEATTY, Kimberly
ZANE, Hannah
DOH, Julia
Title: METHODS AND COMPOSITIONS USEFUL IN DETECTING PROTEINS
Abstract:
Disclosed herein are compositions, reagents, and methods that can be used to observe multiple targets. The targets can be observed using a variety of methods, for example, by fluorescence, EM, and CLEM. The systems and methods involve the use of self-sorting coiled-coil heterodimers that label multiple proteins in a sample. These compositions, interchangeably termed "VIP tags" herein can be used to efficiently label cellular proteins with high specificity.