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1. (WO2018089427) NITRITE SALTS OF 1, 1-DIMETHYLBIGUANIDE, PHARMACEUTICAL COMPOSITIONS, AND METHODS OF USE

Pub. No.:    WO/2018/089427    International Application No.:    PCT/US2017/060541
Publication Date: Fri May 18 01:59:59 CEST 2018 International Filing Date: Thu Nov 09 00:59:59 CET 2017
IPC: A61K 31/155
A61P 3/10
A61K 33/02
Applicants: NOVOMEDIX, LLC
Inventors: FUNG, Leah, M.
CHAN, Kyle, W., H.
SULLIVAN, Robert, W.
SWINDLEHURST, Cathy, A.
Title: NITRITE SALTS OF 1, 1-DIMETHYLBIGUANIDE, PHARMACEUTICAL COMPOSITIONS, AND METHODS OF USE
Abstract:
Provided herein are nitrite salts of 1,1-dimethylbiguanide; and isotopic variants thereof; and pharmaceutically acceptable hydrates and solvates thereof. Also provided herein are their pharmaceutical compositions and methods of use for treating, preventing, or ameliorating one or more symptoms of diseases associated with and/or caused by an abnormal blood glucose level. Further provided herein are methods of their use for treating, preventing, or ameliorating one or more symptoms of a cardiovascular disease.