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1. (WO2018089423) CD38-NAD+ REGULATED METABOLIC AXIS IN ANTI-TUMOR IMMUNOTHERAPY
Latest bibliographic data on file with the International Bureau    Submit observation

Pub. No.: WO/2018/089423 International Application No.: PCT/US2017/060537
Publication Date: 17.05.2018 International Filing Date: 08.11.2017
IPC:
A61K 35/17 (2015.01) ,A61K 35/26 (2015.01) ,C07K 16/30 (2006.01) ,C12N 5/0783 (2010.01)
Applicants: MUSC FOUNDATION FOR RESEARCH DEVELOPMENT[US/US]; 19 Hagood Avenue, Suite 909 Charleston, SC 29425, US
Inventors: MEHROTRA, Shikhar; US
CHATTERJEE, Shilpak; US
Agent: BYRD, Marshall, P.; US
Priority Data:
62/419,61209.11.2016US
Title (EN) CD38-NAD+ REGULATED METABOLIC AXIS IN ANTI-TUMOR IMMUNOTHERAPY
(FR) AXE MÉTABOLIQUE RÉGULÉ CD38-NAD+ EN IMMUNOTHÉRAPIE ANTITUMORALE
Abstract: front page image
(EN) The present disclosure provides methods of producing hybrid Th1/Th17 cells. Also provided herein are methods of treating cancer comprising targeting the CD38- mediated metabolic axis.
(FR) La présente invention concerne des procédés de production de cellules Th1/Th17 hybrides. L'invention concerne également des procédés de traitement du cancer comprenant le ciblage de l'axe métabolique médié par CD38.
Designated States: AE, AG, AL, AM, AO, AT, AU, AZ, BA, BB, BG, BH, BN, BR, BW, BY, BZ, CA, CH, CL, CN, CO, CR, CU, CZ, DE, DJ, DK, DM, DO, DZ, EC, EE, EG, ES, FI, GB, GD, GE, GH, GM, GT, HN, HR, HU, ID, IL, IN, IR, IS, JO, JP, KE, KG, KH, KN, KP, KR, KW, KZ, LA, LC, LK, LR, LS, LU, LY, MA, MD, ME, MG, MK, MN, MW, MX, MY, MZ, NA, NG, NI, NO, NZ, OM, PA, PE, PG, PH, PL, PT, QA, RO, RS, RU, RW, SA, SC, SD, SE, SG, SK, SL, SM, ST, SV, SY, TH, TJ, TM, TN, TR, TT, TZ, UA, UG, US, UZ, VC, VN, ZA, ZM, ZW
African Regional Intellectual Property Organization (ARIPO) (BW, GH, GM, KE, LR, LS, MW, MZ, NA, RW, SD, SL, ST, SZ, TZ, UG, ZM, ZW)
Eurasian Patent Office (AM, AZ, BY, KG, KZ, RU, TJ, TM)
European Patent Office (EPO) (AL, AT, BE, BG, CH, CY, CZ, DE, DK, EE, ES, FI, FR, GB, GR, HR, HU, IE, IS, IT, LT, LU, LV, MC, MK, MT, NL, NO, PL, PT, RO, RS, SE, SI, SK, SM, TR)
African Intellectual Property Organization (BF, BJ, CF, CG, CI, CM, GA, GN, GQ, GW, KM, ML, MR, NE, SN, TD, TG)
Publication Language: English (EN)
Filing Language: English (EN)