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1. (WO2018089406) ROR GAMMA MODULATORS

Pub. No.:    WO/2018/089406    International Application No.:    PCT/US2017/060507
Publication Date: Fri May 18 01:59:59 CEST 2018 International Filing Date: Thu Nov 09 00:59:59 CET 2017
IPC: C07D 413/14
C07D 403/04
C07D 403/06
C07D 403/14
C07D 407/12
C07D 207/02
C07D 207/06
C07D 207/16
C07D 207/24
A61K 31/357
A61K 31/4155
A61K 31/445
A61K 31/506
A61P 3/00
A61P 11/00
A61P 17/04
A61P 29/00
A61P 35/00
A61P 37/00
Applicants: BRISTOL-MYERS SQUIBB COMPANY
Inventors: DUAN, Jingwu
JIANG, Bin
DHAR, T.G. Murali
LU, Zhonghui
GUPTA, Arun Kumar
KARMAKAR, Ananta
Title: ROR GAMMA MODULATORS
Abstract:
There are described RORɣ modulators of the formula (I), or stereoisomers, tautomers, pharmaceutically acceptable salts, solvates, or prodrugs thereof, wherein all substituents are defined herein. Also provided are pharmaceutical compositions comprising the same. Such compounds and compositions are useful in methods for modulating RORɣ activity in a cell and methods for treating a subject suffering from a disease or disorder in which the subject would therapeutically benefit from modulation of RORɣ activity, for example, autoimmune and/or inflammatory disorders.