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1. (WO2018089402) TRICYCLIC SULFONES AS ROR GAMMA MODULATORS
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Pub. No.: WO/2018/089402 International Application No.: PCT/US2017/060501
Publication Date: 17.05.2018 International Filing Date: 08.11.2017
IPC:
C07D 213/75 (2006.01) ,C07D 213/81 (2006.01) ,C07D 309/10 (2006.01) ,C07D 215/36 (2006.01) ,C07D 231/06 (2006.01) ,C07D 231/08 (2006.01) ,C07D 231/18 (2006.01) ,C07D 333/48 (2006.01) ,C07D 233/64 (2006.01) ,C07D 335/02 (2006.01) ,C07D 233/76 (2006.01) ,C07D 233/78 (2006.01) ,C07D 233/90 (2006.01) ,C07D 401/04 (2006.01) ,C07D 401/12 (2006.01) ,C07D 405/04 (2006.01) ,C07D 405/12 (2006.01) ,C07D 241/08 (2006.01) ,C07D 249/12 (2006.01) ,C07D 471/04 (2006.01) ,C07D 471/10 (2006.01) ,C07D 257/04 (2006.01) ,C07D 261/18 (2006.01) ,C07D 263/20 (2006.01) ,C07D 205/04 (2006.01) ,C07D 207/09 (2006.01) ,C07D 207/10 (2006.01) ,C07D 207/16 (2006.01) ,C07D 207/28 (2006.01) ,C07D 285/06 (2006.01) ,C07D 211/48 (2006.01) ,C07D 211/62 (2006.01) ,C07D 295/16 (2006.01) ,C07D 211/78 (2006.01) ,C07D 211/96 (2006.01) ,C07D 213/40 (2006.01) ,C07D 213/56 (2006.01) ,C07D 305/08 (2006.01) ,C07D 307/22 (2006.01) ,C07F 9/09 (2006.01) ,C07C 317/20 (2006.01) ,A61K 31/45 (2006.01) ,A61K 31/4409 (2006.01) ,A61K 31/495 (2006.01) ,A61K 31/5375 (2006.01) ,A61K 31/381 (2006.01) ,A61K 31/382 (2006.01) ,A61K 31/437 (2006.01) ,A61K 31/341 (2006.01) ,A61K 31/54 (2006.01) ,A61K 31/40 (2006.01) ,A61K 31/4152 (2006.01) ,A61K 31/4545 (2006.01) ,A61K 31/438 (2006.01) ,A61K 31/397 (2006.01) ,A61K 31/4164 (2006.01) ,A61K 31/433 (2006.01) ,A61K 31/337 (2006.01) ,A61K 31/4412 (2006.01) ,A61K 31/41 (2006.01) ,A61K 31/473 (2006.01) ,A61K 31/4439 (2006.01) ,A61K 31/421 (2006.01) ,A61K 31/4166 (2006.01) ,A61K 31/42 (2006.01) ,A61K 31/505 (2006.01) ,A61K 31/4196 (2006.01) ,A61P 3/00 (2006.01) ,A61P 11/06 (2006.01) ,A61P 35/00 (2006.01) ,A61P 37/08 (2006.01)
[IPC code unknown for C07D 213/75][IPC code unknown for C07D 213/81][IPC code unknown for C07D 309/10][IPC code unknown for C07D 215/36][IPC code unknown for C07D 231/06][IPC code unknown for C07D 231/08][IPC code unknown for C07D 231/18][IPC code unknown for C07D 333/48][IPC code unknown for C07D 233/64][IPC code unknown for C07D 335/02][IPC code unknown for C07D 233/76][IPC code unknown for C07D 233/78][IPC code unknown for C07D 233/90][IPC code unknown for C07D 401/04][IPC code unknown for C07D 401/12][IPC code unknown for C07D 405/04][IPC code unknown for C07D 405/12][IPC code unknown for C07D 241/08][IPC code unknown for C07D 249/12][IPC code unknown for C07D 471/04][IPC code unknown for C07D 471/10][IPC code unknown for C07D 257/04][IPC code unknown for C07D 261/18][IPC code unknown for C07D 263/20][IPC code unknown for C07D 205/04][IPC code unknown for C07D 207/09][IPC code unknown for C07D 207/10][IPC code unknown for C07D 207/16][IPC code unknown for C07D 207/28][IPC code unknown for C07D 285/06][IPC code unknown for C07D 211/48][IPC code unknown for C07D 211/62][IPC code unknown for C07D 295/16][IPC code unknown for C07D 211/78][IPC code unknown for C07D 211/96][IPC code unknown for C07D 213/40][IPC code unknown for C07D 213/56][IPC code unknown for C07D 305/08][IPC code unknown for C07D 307/22][IPC code unknown for C07F 9/09][IPC code unknown for C07C 317/20][IPC code unknown for A61K 31/45][IPC code unknown for A61K 31/4409][IPC code unknown for A61K 31/495][IPC code unknown for A61K 31/5375][IPC code unknown for A61K 31/381][IPC code unknown for A61K 31/382][IPC code unknown for A61K 31/437][IPC code unknown for A61K 31/341][IPC code unknown for A61K 31/54][IPC code unknown for A61K 31/40][IPC code unknown for A61K 31/4152][IPC code unknown for A61K 31/4545][IPC code unknown for A61K 31/438][IPC code unknown for A61K 31/397][IPC code unknown for A61K 31/4164][IPC code unknown for A61K 31/433][IPC code unknown for A61K 31/337][IPC code unknown for A61K 31/4412][IPC code unknown for A61K 31/41][IPC code unknown for A61K 31/473][IPC code unknown for A61K 31/4439][IPC code unknown for A61K 31/421][IPC code unknown for A61K 31/4166][IPC code unknown for A61K 31/42][IPC code unknown for A61K 31/505][IPC code unknown for A61K 31/4196][IPC code unknown for A61P 3][IPC code unknown for A61P 11/06][IPC code unknown for A61P 35][IPC code unknown for A61P 37/08]
Applicants:
BRISTOL-MYERS SQUIBB COMPANY [US/US]; Route 206 and ProvinceLine Road Princeton, New Jersey 08543, US
Inventors:
MARCOUX, David; US
BEAUDOIN BERTRAND, Myra; US
DHAR, T.G. Murali; US
YANG, Michael G.; US
XIAO, Zili; US
XIAO, Hai-Yun; US
ZHU, Yeheng; US
WEIGELT, Carolyn, A.; US
BATT, Douglas G.; US
Agent:
KORSEN, Elliott; US
CLAUSS, Isabelle M.; US
DELAUNEY, Ashton J.; US
FARQUHARSON TORRES, Serena; US
GOLIAN, Paul D.; US
GREENBLATT, Gary D.; US
GUO, Z. Angela; US
HADAD, Henry; US
HAN, Bo; US
JACOBSEN, Barry; US
LIU, Hong; US
LU, Yong; US
PARLET, Nickki L.; US
SUN, Jing G.; US
VANATTEN, Mary K.; US
VOM WEGE, Julia; US
WALSH, Brian J.; US
EPPERSON, James; US
MINGO, Pamela A.; US
BELLOMY, Gregory R.; US
CHAO, Yuan; US
HAI, Bing; US
Priority Data:
62/419,60709.11.2016US
Title (EN) TRICYCLIC SULFONES AS ROR GAMMA MODULATORS
(FR) SULFONES TRICYCLIQUES EN TANT QUE MODULATEURS DE ROR GAMMA
Abstract:
(EN) There are described RORγ Gamma modulators of the formula (I), (I) or stereoisomers, tautomers, pharmaceutically acceptable salts, solvates, or prodrugs thereof, wherein all substituents are defined herein. Also provided are pharmaceutical compositions comprising the same. Such compounds and compositions are useful in methods for modulating RORγ activity in a cell and methods for treating a subject suffering from a disease or disorder in which the subject would therapeutically benefit from modulation of RORγ activity, for example, autoimmune and/or inflammatory disorders.
(FR) La présente invention concerne des modulateurs de RORγ de formule (I), (I) ou des stéréoisomères, des tautomères, des sels, des solvates ou des promédicaments pharmaceutiquement acceptables de ceux-ci, tous les substituants étant tels que définis dans la description. La présente invention concerne en outre des compositions pharmaceutiques comprenant lesdits modulateurs. Les composés et les compositions de la présente invention sont utiles dans des procédés de modulation de l'activité RORγ dans une cellule, et dans des procédés destinés à traiter un patient atteint d'une maladie ou d'un trouble, où ledit patient peut tirer un avantage thérapeutique de la modulation de l'activité RORγ, par exemple, dans le cas de troubles auto-immuns et/ou inflammatoires.
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Designated States: AE, AG, AL, AM, AO, AT, AU, AZ, BA, BB, BG, BH, BN, BR, BW, BY, BZ, CA, CH, CL, CN, CO, CR, CU, CZ, DE, DJ, DK, DM, DO, DZ, EC, EE, EG, ES, FI, GB, GD, GE, GH, GM, GT, HN, HR, HU, ID, IL, IN, IR, IS, JO, JP, KE, KG, KH, KN, KP, KR, KW, KZ, LA, LC, LK, LR, LS, LU, LY, MA, MD, ME, MG, MK, MN, MW, MX, MY, MZ, NA, NG, NI, NO, NZ, OM, PA, PE, PG, PH, PL, PT, QA, RO, RS, RU, RW, SA, SC, SD, SE, SG, SK, SL, SM, ST, SV, SY, TH, TJ, TM, TN, TR, TT, TZ, UA, UG, US, UZ, VC, VN, ZA, ZM, ZW
African Regional Intellectual Property Organization (ARIPO) (BW, GH, GM, KE, LR, LS, MW, MZ, NA, RW, SD, SL, ST, SZ, TZ, UG, ZM, ZW)
Eurasian Patent Office (AM, AZ, BY, KG, KZ, RU, TJ, TM)
European Patent Office (EPO) (AL, AT, BE, BG, CH, CY, CZ, DE, DK, EE, ES, FI, FR, GB, GR, HR, HU, IE, IS, IT, LT, LU, LV, MC, MK, MT, NL, NO, PL, PT, RO, RS, SE, SI, SK, SM, TR)
African Intellectual Property Organization (BF, BJ, CF, CG, CI, CM, GA, GN, GQ, GW, KM, ML, MR, NE, SN, TD, TG)
Publication Language: English (EN)
Filing Language: English (EN)