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1. (WO2018089393) BINDING MOLECULES SPECIFIC FOR ASCT2 AND USES THEREOF
Latest bibliographic data on file with the International Bureau    Submit observation

Pub. No.: WO/2018/089393 International Application No.: PCT/US2017/060489
Publication Date: 17.05.2018 International Filing Date: 08.11.2017
IPC:
A61K 39/395 (2006.01) ,A61K 47/68 (2017.01) ,C07K 16/18 (2006.01) ,C07K 16/30 (2006.01) ,G01N 33/574 (2006.01)
A HUMAN NECESSITIES
61
MEDICAL OR VETERINARY SCIENCE; HYGIENE
K
PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
39
Medicinal preparations containing antigens or antibodies
395
Antibodies; Immunoglobulins; Immune serum, e.g. antilymphocytic serum
[IPC code unknown for A61K 47/68]
C CHEMISTRY; METALLURGY
07
ORGANIC CHEMISTRY
K
PEPTIDES
16
Immunoglobulins, e.g. monoclonal or polyclonal antibodies
18
against material from animals or humans
C CHEMISTRY; METALLURGY
07
ORGANIC CHEMISTRY
K
PEPTIDES
16
Immunoglobulins, e.g. monoclonal or polyclonal antibodies
18
against material from animals or humans
28
against receptors, cell surface antigens or cell surface determinants
30
from tumour cells
G PHYSICS
01
MEASURING; TESTING
N
INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
33
Investigating or analysing materials by specific methods not covered by groups G01N1/-G01N31/131
48
Biological material, e.g. blood, urine; Haemocytometers
50
Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
53
Immunoassay; Biospecific binding assay; Materials therefor
574
for cancer
Applicants: MEDIMMUNE, LLC[US/US]; One MedImmune Way Gaithersburg, MD 20878, US
Inventors: PORE, Nabendu; US
BORROK III, Martin, J.; US
CHOWDHURY, Partha, S.; US
MICHELOTTI, Emil, F.; US
TICE, David, A.; US
HOLLINGSWORTH, Robert, E.; US
CHANG, Chien-Ying; US
HURT, Elaine, M.; US
YAO, Nai, Shun; US
Agent: GALVEZ, J., Jason; US
DISE, Rebecca, S.; US
ALBAN, Patrick, Scott; US
CARROLL, Shannon; US
BRASLOW, Kimberly, D.; US
Priority Data:
62/420,00810.11.2016US
62/501,92305.05.2017US
Title (EN) BINDING MOLECULES SPECIFIC FOR ASCT2 AND USES THEREOF
(FR) MOLÉCULES DE LIAISON SPÉCIFIQUES D'ASCT2 ET LEURS UTILISATIONS
Abstract:
(EN) This disclosure provides ASCT2-binding molecules, e.g., anti-ASCT2 antibodies, and antigen-binding fragments thereof, used in methods related to cancer stem cells, e.g., binding to a cancer stem cell. In certain aspects, the ASCT2-binding molecules are conjugated to cytotoxic drugs, e.g., ASCT2 antibody-drug conjugates. In certain aspects, the ASCT2-binding molecules bind specifically to cancer stem cells expressing ASCT2.
(FR) L'invention concerne des molécules de liaison à ASCT2, par exemple des anticorps anti-ASCT2, et leurs fragments liant l'antigène, utilisés dans des méthodes associées à des cellules souches cancéreuses, par exemple la liaison à une cellule souche cancéreuse. Dans certains aspects, les molécules de liaison à ASCT2 sont conjuguées à des médicaments cytotoxiques, par exemple des conjugués médicaments-anticorps anti-ASCT2. Dans certains aspects, les molécules de liaison à ASCT2 se lient spécifiquement à des cellules souches cancéreuses exprimant ASCT2.
front page image
Designated States: AE, AG, AL, AM, AO, AT, AU, AZ, BA, BB, BG, BH, BN, BR, BW, BY, BZ, CA, CH, CL, CN, CO, CR, CU, CZ, DE, DJ, DK, DM, DO, DZ, EC, EE, EG, ES, FI, GB, GD, GE, GH, GM, GT, HN, HR, HU, ID, IL, IN, IR, IS, JO, JP, KE, KG, KH, KN, KP, KR, KW, KZ, LA, LC, LK, LR, LS, LU, LY, MA, MD, ME, MG, MK, MN, MW, MX, MY, MZ, NA, NG, NI, NO, NZ, OM, PA, PE, PG, PH, PL, PT, QA, RO, RS, RU, RW, SA, SC, SD, SE, SG, SK, SL, SM, ST, SV, SY, TH, TJ, TM, TN, TR, TT, TZ, UA, UG, US, UZ, VC, VN, ZA, ZM, ZW
African Regional Intellectual Property Organization (ARIPO) (BW, GH, GM, KE, LR, LS, MW, MZ, NA, RW, SD, SL, ST, SZ, TZ, UG, ZM, ZW)
Eurasian Patent Office (AM, AZ, BY, KG, KZ, RU, TJ, TM)
European Patent Office (EPO) (AL, AT, BE, BG, CH, CY, CZ, DE, DK, EE, ES, FI, FR, GB, GR, HR, HU, IE, IS, IT, LT, LU, LV, MC, MK, MT, NL, NO, PL, PT, RO, RS, SE, SI, SK, SM, TR)
African Intellectual Property Organization (BF, BJ, CF, CG, CI, CM, GA, GN, GQ, GW, KM, ML, MR, NE, SN, TD, TG)
Publication Language: English (EN)
Filing Language: English (EN)